Rheumatoid Arthritis – Determining the best treatment for each person




Scientific study title:

Living Systematic Reviews of Pharmacological Treatments for Rheumatoid Arthritis



Principal Investigator:

Glen Hazlewood, MD, PhD, FRCPC,
Associate Professor, Division of Rheumatology, Department of Medicine, Cumming School of Medicine, University of Calgary
Research Scientist, Arthritis Research Canada

Peter Tugwell, MSc, MD, FRCPC, Professor and holder of the Canada Research Chair in Health Equity, University of Ottawa

George Wells, MSc, PhD, Professor, School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa


Study Start Date:

October 2021

Study End Date:

September 2025


Why do this research?

Rheumatoid arthritis (RA) is a disease that involves inflammation of the joints, tendons and the tissues surrounding the joints. It can limit a person’s ability to carry out activities and lead to a reduced quality of life. For some patients it can lead to joint destruction, severe disability, and disfigurement. There are several treatments available for RA and treatment options are constantly increasing. Basing recommendations for treatment on the most up to date information is important for good patient care.




What will we do?

We will create a new approach for identifying, updating and assembling new information on treatments for RA. We will compare the various treatments with each other so that we can determine which treatment is most beneficial or harmful. In addition we will be identifying and constantly updating and including new information on treatment for RA as it becomes available. We will also identify the best treatment for patients with RA based on previous treatment history. The results of this study will allow for informative discussions between patients and clinicians.



How are Equity, Diversity and Inclusion addressed or taken into consideration?

We will be analyzing how treatment responses differ according to equity considerations, which may help better tailor treatment decisions for populations at risk of inequity.



Nick Bansback, MSc, PhD, Associate Professor, School of Population and Public Health,
University of British Columbia, Research Scientist, Arthritis Research Canada
Claire Barber, MD, PhD, FRCPC, Associate Professor, Division of Rheumatology, Department of Medicine and Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Research Scientist, Arthritis Research Canada
Jesse Elliott, MSc, PhD, Health Economist, CADTH
Mohammed Kamso, PhD Candidate (Biostatistics), McCaig Institute for Bone and Joint Health, University of Calgary
Shannon Kelly, MSc, PhD (c)
Lara Maxwell, MSc, Research Coordinator, University of Ottawa


How do people get involved?

The project will use data that is already collected so there is no participant recruitment.



Funding Agency

Canadian Institutes of Health Research