Glen Hazlewood

Research Scientist, MD, PhD, FRCPC

Appointments

  • Assistant Professor, Division of Rheumatology, Department of Medicine, Cumming School of Medicine, University of Calgary

Research Interests

  • Rheumatoid arthritis treatment
  • Patient preferences

Dr. Glen Hazlewood is a rheumatologist and clinician scientist. He completed his rheumatology training in 2010 at the University of Calgary and his PhD in clinical epidemiology through the University of Toronto in 2015. He is currently an Assistant Professor in the Department of Medicine in Calgary.

Learn more

Dr. Hazlewood’s program of research is focused on understanding how to align treatment choices in rheumatoid arthritis with best evidence and patients’ preferences. His research is guided by a belief that patients should have a central role in which treatments they take and which treatments we recommend for them. He chairs the Guidelines Committee through the Canadian Rheumatology Association and is leading the development of the Canadian Guidelines for Rheumatoid Arthritis. With these guidelines, he is taking a novel approach to incorporating patients’ preferences – a first internationally.

 

His methodological interests include: comparative effectiveness research (observational data, network meta-analyses, pragmatic clinical trials), patient preference research (both qualitative methods and discrete-choice experiment), advanced Bayesian methods of data analysis, and guideline development and shared decision making. His clinical area of research is rheumatoid arthritis, although he has also established collaborations with researchers in other diseases, applying similar methods (e.g. Crohn’s disease, atrial fibrillation, chronic kidney disease).

 

Dr. Hazlewood’ has published his research in top-tier medical journals and his research has been funded through multiple peer-reviewed grants including 3 CIHR grants. He is funded through both a CIHR New Investigator Award and an Arthritis Society Young Investigator Award.

Publications

Cholapranee, A., Hazlewood, G.S., Kaplan, G.G., Peyrin-Biroulet, L., Ananthakrishnan, A.N. Systematic review with meta-analysis: comparative efficacy of biologics for induction and maintenance of mucosal healing in Crohn’s disease and ulcerative colitis controlled trials (2017) Alimentary Pharmacology and Therapeutics, 45 (10), pp. 1291-1302. Cited 1 time. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016075263&doi=10.1111%2fapt.14030&partnerID=40&md5=7a3c2ca6f3cfdecd4b748785ee415bc8

 

Coward, S., Kuenzig, M.E., Hazlewood, G., Clement, F., McBrien, K., Holmes, R., Panaccione, R., Ghosh, S., Seow, C.H., Rezaie, A., Kaplan, G.G. Comparative Effectiveness of Mesalamine, Sulfasalazine, Corticosteroids, and Budesonide for the Induction of Remission in Crohn’s Disease: A Bayesian Network Meta-analysis: Republished (2017) Inflammatory Bowel Diseases, 23 (5), pp. E26-E37. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019842924&doi=10.1097%2fMIB.0000000000001023&partnerID=40&md5=06ed2a0efe0977428131723e3315208b

 

Omair, M.A., Keystone, E., Bykerk, V., Lin, D., Xiong, J., Sun, Y., Boire, G., Thorne, J.C., Tin, D., Pope, J., Hitchon, C., Haraoui, B., Akhavan, P.S., Ahluwalia, V., Barnabe, C., Baron, M., Bensen, W., Colmegna, I., Haraoui, P., Hazlewood, G., Jamal, S., Kuriya, B., Kinkhoff, A., Kraishi, M., Larche, M., Lyddell, C., Nair, B., Penney, C., Rubin, L., Zummer, M. Predicting Low Disease State and Remission in Early Rheumatoid Arthritis in the First Six Months, Comparing the Simplified Disease Activity Index and European League Against Rheumatism Response Measures: Results From an Early Arthritis Cohort (2017) Arthritis Care and Research, 69 (5), pp. 737-741. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017449108&doi=10.1002%2facr.22983&partnerID=40&md5=537d8a0b5b0336f78f3d0abfc0cb288e

 

Barra, L.J., Pope, J.E., Hitchon, C., Boire, G., Schieir, O., Lin, D., Thorne, C.J., Tin, D., Keystone, E.C., Haraoui, B., Jamal, S., Bykerk, V.P., Ahluwalia, V., Akhavan, P., Barra, L., Barber, C., Barnabe, C., Bartlett, S., Baron, M., Bessette, L., Boire, G., Bykerk, V., Colmegna, I., Fallavollita, S., Haaland, D., Haraoui, B., Hazlewood, G., Hitchon, C., Jamal, S., Keystone, E., Kuriya, B., Larche, M., Lyddell, C., Nair, B., Penney, C., Pope, J., Rubin, L., Tremblay, J.-L., Thorne, C., Villeneuve, S., Zummer, M. The effect of rheumatoid arthritis-associated autoantibodies on the incidence of cardiovascular events in a large inception cohort of early inflammatory arthritis (2017) Rheumatology (United Kingdom), 56 (5), pp. 768-776. Cited 1 time. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019687833&doi=10.1093%2frheumatology%2fkew474&partnerID=40&md5=5ab9ec8d30d5b556f40485ba22755733

 

Coward, S., Kuenzig, M.E., Hazlewood, G., Clement, F., McBrien, K., Holmes, R., Panaccione, R., Ghosh, S., Seow, C.H., Rezaie, A., Kaplan, G.G. Comparative Effectiveness of Mesalamine, Sulfasalazine, Corticosteroids, and Budesonide for the Induction of Remission in Crohn’s Disease: A Bayesian Network Meta-Analysis (2017) Inflammatory Bowel Diseases, 23 (3), pp. 461-472. Cited 2 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013770082&doi=10.1097%2fMIB.0000000000001023&partnerID=40&md5=a3ffa4305cbf02ba5f678a9aeceb3fe2

 

Liu, Y., Hazlewood, G.S., Kaplan, G.G., Eksteen, B., Barnabe, C. Impact of Obesity on Remission and Disease Activity in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis (2017) Arthritis Care and Research, 69 (2), pp. 157-165. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85007439590&doi=10.1002%2facr.22932&partnerID=40&md5=48617e0be4ed392f4c1402ce5bc749ba

 

Mao, E.J., Hazlewood, G.S., Kaplan, G.G., Peyrin-Biroulet, L., Ananthakrishnan, A.N. Systematic review with meta-analysis: comparative efficacy of immunosuppressants and biologics for reducing hospitalisation and surgery in Crohn’s disease and ulcerative colitis (2017) Alimentary Pharmacology and Therapeutics, 45 (1), pp. 3-13. Cited 3 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85001967776&doi=10.1111%2fapt.13847&partnerID=40&md5=60e20587e7bac66107969723c49d06ee

 

Hazlewood, G.S., Bombardier, C., Tomlinson, G., Thorne, C., Bykerk, V.P., Thompson, A., Tin, D., Marshall, D.A. Treatment preferences of patients with early rheumatoid arthritis: A discrete-choice experiment (2016) Rheumatology (United Kingdom), 55 (11), pp. 1959-1968. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84997235799&doi=10.1093%2frheumatology%2fkew280&partnerID=40&md5=66f65822771514b43856847cb2ec1fb1

 

Hazlewood, G.S., Barr, S.G., Lopatina, E., Marshall, D.A., Lupton, T.L., Fritzler, M.J., Mosher, D.P., Steber, W.A., Martin, L. Improving Appropriate Access to Care With Central Referral and Triage in Rheumatology (2016) Arthritis Care and Research, 68 (10), pp. 1547-1553. Cited 1 time. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988979018&doi=10.1002%2facr.22845&partnerID=40&md5=5df4790c523e0ab3de774f4ee1c03227

 

Hazlewood, G.S., Barnabe, C., Tomlinson, G., Marshall, D., Devoe, D.J.A., Bombardier, C. Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis (2016) Cochrane Database of Systematic Reviews, 2016 (8), art. no. CD010227, . Cited 1 time. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983739150&doi=10.1002%2f14651858.CD010227.pub2&partnerID=40&md5=d64a26394b36742274a0a25fc46abd4a

 

Hazlewood, G.S., Thorne, J.C., Pope, J.E., Lin, D., Tin, D., Boire, G., Haraoui, B., Hitchon, C.A., Keystone, E.C., Jamal, S., Bykerk, V.P. The comparative effectiveness of oral versus subcutaneous methotrexate for the treatment of early rheumatoid arthritis (2016) Annals of the Rheumatic Diseases, 75 (6), pp. 1003-1008. Cited 9 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969964172&doi=10.1136%2fannrheumdis-2014-206504&partnerID=40&md5=6f0e6fd130db2190c81d97d0de2dedbd

 

Hazlewood, G.S., Barnabe, C., Tomlinson, G., Marshall, D., Devoe, D., Bombardier, C. Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic drugs for rheumatoid arthritis: Abridged cochrane Systematic review and network meta-analysis (2016) BMJ (Online), 353, art. no. i1777, . Cited 27 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964584679&doi=10.1136%2fbmj.i1777&partnerID=40&md5=ddc232d9eb53d0cfb359c87605f451d7

 

Sun, G., Hazlewood, G., Bernatsky, S., Kaplan, G.G., Eksteen, B., Barnabe, C. Association between Air Pollution and the Development of Rheumatic Disease: A Systematic Review (2016) International Journal of Rheumatology, 2016, art. no. 5356307, . Cited 2 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994552808&doi=10.1155%2f2016%2f5356307&partnerID=40&md5=d7c40c501fc73e3d93a598191aa95115

 

Barber, C.E.H., Marshall, D.A., Alvarez, N., John Mancini, G.B., Lacaille, D., Keeling, S., Antonio Aviña-Zubieta, J., Khodyakov, D., Barnabe, C., Faris, P., Smith, A., Noormohamed, R., Hazlewood, G., Martin, L.O., Esdaile, J.M. Development of cardiovascular quality indicators for rheumatoid arthritis: Results from an international expert panel using a novel online process (2015) Journal of Rheumatology, 42 (9), pp. 1548-1555. Cited 11 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940706778&doi=10.3899%2fjrheum.141603&partnerID=40&md5=3598c20e466d58b3ba31e7a67831c18e

 

Barnabe, C., Sun, Y., Boire, G., Hitchon, C.A., Haraoui, B., Thorne, J.C., Tin, D., Van Der Heijde, D., Curtis, J.R., Jamal, S., Pope, J.E., Keystone, E.C., Bartlett, S., Bykerk, V.P., Kraishi, M., Zummer, M., Baron, M., Bessette, L., Akhavan, P., Rubin, L., Bensen, W., Ahluwalia, V., Nair, B., Hazlewood, G., Mosher, D., Penney, C., Lyddell, C. Heterogeneous disease trajectories explain variable radiographic, function and quality of life outcomes in the Canadian Early Arthritis Cohort (CATCH) (2015) PLoS ONE, 10 (8), art. no. e0135327, . Cited 2 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84943180366&doi=10.1371%2fjournal.pone.0135327&partnerID=40&md5=7e02691fab0b332ffe4fe4587d20b0fa

 

Chow, S.L., Thorne, J.C., Bell, M.J., Ferrari, R., Bagheri, Z., Boyd, T., Colwill, A.M., Jung, M., Frackowiak, D., Hazlewood, G.S., Kuriya, B., Tugwell, P. Choosing wisely: The Canadian rheumatology association’s list of 5 items physicians and patients should question (2015) Journal of Rheumatology, 42 (4), pp. 682-689. Cited 11 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940436944&doi=10.3899%2fjrheum.141140&partnerID=40&md5=1d52aeee0b4d3f5c8e0416c016d395e8

 

Barber, C.E.H., Smith, A., Esdaile, J.M., Barnabe, C., Martin, L.O., Faris, P., Hazlewood, G., Noormohamed, R., Alvarez, N., Mancini, G.B.J., Lacaille, D., Keeling, S., Aviña-Zubieta, J.A., Marshall, D. Best practices for cardiovascular disease prevention in rheumatoid arthritis: A systematic review of guideline recommendations and quality indicators (2015) Arthritis Care and Research, 67 (2), pp. 169-179. Cited 14 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922017975&doi=10.1002%2facr.22419&partnerID=40&md5=4801110e4723591a856fa27a2dfe78a5

 

Hazlewood, G.S., Rezaie, A., Borman, M., Panaccione, R., Ghosh, S., Seow, C.H., Kuenzig, E., Tomlinson, G., Siegel, C.A., Melmed, G.Y., Kaplan, G.G. Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remission in Crohn’s disease: A network meta-analysis (2015) Gastroenterology, 148 (2), pp. 344-354. Cited 66 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921325308&doi=10.1053%2fj.gastro.2014.10.011&partnerID=40&md5=ed137efa716c5e4a2321f39d271e32a4

 

Hazlewood, G.S., Metzler, C., Tomlinson, G.A., Gross, W.L., Feldman, B.M., Guillevin, L., Pagnoux, C. Non-biologic remission maintenance therapy in adult patients with ANCA-associated vasculitis: A systematic review and network meta-analysis (2014) Joint Bone Spine, 81 (4), pp. 337-341. Cited 11 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904116116&doi=10.1016%2fj.jbspin.2013.11.006&partnerID=40&md5=c1982e082f13b107aeaa585721b7f02e

 

Hazlewood, G.S., Akhavan, P., Schieir, O., Marshall, D., Tomlinson, G., Bykerk, V., Bombardier, C. Adding a “gRADE” to the quality appraisal of rheumatoid arthritis guidelines identifies limitations beyond AGREE-II (2014) Journal of Clinical Epidemiology, 67 (11), pp. 1274-1285. Cited 6 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84908227513&doi=10.1016%2fj.jclinepi.2014.07.005&partnerID=40&md5=6d842ebadb74cb0a1162e041f1e6d79c

 

Hazlewood, G.S., Metzler, C., Tomlinson, G.A., Gross, W.L., Feldman, B.M., Guillevin, L., Pagnoux, C. Non-biologic remission maintenance therapy in adult patients with ANCA-associated vasculitis: A systematic literature review and network meta-analysis [Maintien de la rémission sans biothérapie chez les patients adultes atteints de vascularite à ANCA: revue systématique de la littérature et méta-analyse en réseau] (2014) Revue du Rhumatisme (Edition Francaise), 81 (4), pp. 318-323. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904291568&doi=10.1016%2fj.rhum.2014.01.005&partnerID=40&md5=2ef2c6a52823a3c89cd82d22f5d61007

 

Hazlewood, G.S., Naimark, D., Gardam, M., Bykerk, V., Bombardier, C. Prophylaxis for latent tuberculosis infection prior to anti-tumor necrosis factor therapy in low-risk elderly patients with rheumatoid arthritis: A decision analysis (2013) Arthritis Care and Research, 65 (11), pp. 1722-1731. Cited 5 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887072244&doi=10.1002%2facr.22063&partnerID=40&md5=912fbd2c9b318275243905660735433a

 

Harris, J.A., Bykerk, V.P., Hitchon, C.A., Keystone, E.C., Thorne, J.C., Boire, G., Haraoui, B., Hazlewood, G., Bonner, A.J., Pope, J.E. Determining best practices in early rheumatoid arthritis by comparing differences in treatment at sites in the Canadian early arthritis cohort (2013) Journal of Rheumatology, 40 (11), pp. 1823-1830. Cited 10 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887427604&doi=10.3899%2fjrheum.121316&partnerID=40&md5=ef5747fcc211d7420c6e6a3fc92388d7

 

Hazlewood, G.S., Barnabe, C., Barr, S.G., Martin, L. Abatacept use after failure of multiple biologic agents in patients with severe rheumatoid arthritis (2012) Journal of Clinical Rheumatology, 18 (8), pp. 416-418. Cited 2 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871747965&doi=10.1097%2fRHU.0b013e3182784833&partnerID=40&md5=aeb762795f7c58a498d8644087dca5d0

 

Hazlewood, G., Van Der Heijde, D.M., Bombardier, C. Paracetamol for the management of pain in inflammatory arthritis: A systematic literature review (2012) Journal of Rheumatology, 39 (SUPPL. 90), pp. 11-16. Cited 8 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865839395&doi=10.3899%2fjrheum.120336&partnerID=40&md5=d62aa1976bd4119eb84431fb17c97a82

 

Bykerk, V.P., Schieir, O., Akhavan, P., Hazlewood, G.S., Cheng, C.K., Bombardier, C. Emerging issues in pharmacological management of rheumatoid arthritis: Results of a national needs assessment survey identifying practice variations for the development of Canadian Rheumatology Association clinical practice recommendations (2012) Journal of Rheumatology, 39 (8), pp. 1555-1558. Cited 6 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864546733&doi=10.3899%2fjrheum.110208&partnerID=40&md5=f63163703f1409616769ff50b31c168f

 

Bykerk, V.P., Akhavan, P., Hazlewood, G.S., Schieir, O., Dooley, A., Haraoui, B., Khraishi, M., Leclercq, S.A., Légaré, J., Mosher, D.P., Pencharz, J., Pope, J.E., Thomson, J., Thorne, C., Zummer, M., Bombardier, C. Canadian Rheumatology Association recommendations for pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs (2012) Journal of Rheumatology, 39 (8), pp. 1559-1582. Cited 81 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864570470&doi=10.3899%2fjrheum.110207&partnerID=40&md5=3cec1424191b612eb1433ce03477e429

 

Bombardier, C., Hazlewood, G.S., Akhavan, P., Schieir, O., Dooley, A., Haraoui, B., Khraishi, M., Leclercq, S.A., Légaré, J., Mosher, D.P., Pencharz, J., Pope, J.E., Thomson, J., Thorne, C., Zummer, M., Gardam, M.A., Askling, J., Bykerk, V. Canadian rheumatology association recommendations for the pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs: Part II safety (2012) Journal of Rheumatology, 39 (8), pp. 1583-1602. Cited 45 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864542624&doi=10.3899%2fjrheum.120165&partnerID=40&md5=9fcab761e0365c6961f9f8bfa4ee758b

 

Whittle, S.L., Colebatch, A.N., Buchbinder, R., Edwards, C.J., Adams, K., Englbrecht, M., Hazlewood, G., Marks, J.L., Radner, H., Ramiro, S., Richards, B.L., Tarner, I.H., Aletaha, D., Bombardier, C., Landewé, R.B., Müller-ladner, U., Bijlsma, J.W.J., Branco, J.C., Bykerk, V.P., Da rocha castelar pinheiro, G., Catrina, A.I., Hannonen, P., Kiely, P., Leeb, B., Lie, E., Martinez-osuna, P., Montecucco, C., østergaard, M., Westhovens, R., Zochling, J., Van der heijde, D. Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis: Integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e initiative (2012) Rheumatology (United Kingdom), 51 (8), art. no. kes032, pp. 1416-1425. Cited 32 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865172404&doi=10.1093%2frheumatology%2fkes032&partnerID=40&md5=d6ecf62ee703b35c0ea98c5b2059f8a9

 

Barnabe, C., Hazlewood, G., Barr, S., Martin, L. Comparison of radiographic scoring methods in a cohort of RA patients treated with anti-TNF therapy (2012) Rheumatology, 51 (5), art. no. ker418, pp. 878-881. Cited 2 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860233486&doi=10.1093%2frheumatology%2fker418&partnerID=40&md5=272c5fcdc623b5f6487887edd9c7a7ca

 

Hazlewood, G., Aletaha, D., Carmona, L., Landewé, R.B.M., Van Der Heijde, D.M., Bijlsma, J.W.J., Bykerk, V.P., Canhão, H., Catrina, A.I., Durez, P., Edwards, C.J., Leeb, B.F., Mjaavatten, M.D., Martinez-Osuna, P., Montecucco, C., Østergaard, M., Serra-Bonett, N., Xavier, R.M., Zochling, J., Machado, P., Thevissen, K., Vercoutere, W., Bombardier, C. Algorithm for identification of undifferentiated peripheral inflammatory arthritis: A multinational collaboration through the 3e initiative (2011) Journal of Rheumatology, 38 (SUPPL. 87), pp. 54-58. Cited 6 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952423599&doi=10.3899%2fjrheum.101076&partnerID=40&md5=294e95eea7ba4654c86e9bdfe7cd1adc

 

Chalandon, Y., Jiang, X., Hazlewood, G., Loutet, S., Conneally, E., Eaves, A., Eaves, C. Modulation of p210 BCR-ABL activity in transduced primary human hematopoietic cells controls lineage programming (2002) Blood, 99 (9), pp. 3197-3204. Cited 48 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036565871&doi=10.1182%2fblood.V99.9.3197&partnerID=40&md5=5d701cab42e3ab61bf79f08dff20a4df