fbpx

Risk of Retinal Toxicity in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis on Long-term Hydroxychloroquine Therapy

 

Principal Investigator:

J Antonio Avina-Zubieta M.D. M.Sc. Ph.D. FRCPC Senior Research Scientist, Arthritis Research Canada Associate Professor of Medicine, Division of Rheumatology, Department of Medicine, University of British Columbia BC Lupus Society Scholar Michael Smith Foundation for Health Research Scholar

 

Study Start Date:

2019

 

Study End Date:

2024

 

Why do this research?

Systemic lupus erythematosus and rheumatoid arthritis are diseases of the immune system that affect many parts of the body (e.g., joints, heart, eyes, skin), and can result in other medical complications and untimely death. A drug called hydroxychloroquine (HCQ) is commonly used to treat systemic lupus erythematosus and rheumatoid arthritis. Existing studies have highlighted benefits of HCQ, including less severe disease, fewer complications (e.g., blood clots, problems with pregnancy or kidneys), and longer life. However, stopping HCQ can lead to episodes of more severe disease including death. Although HCQ is typically safe, inexpensive and easy to take, a serious long-term side-effect is eye damage that could cause vision loss. Given the benefits and common use of HCQ, it is critical that the real risk be determined and findings shared with doctors and patients so that patients receive the best and safest care, and the health care system can use its dollars wisely.

 

What will be done?

Using the administrative health data, we will identify and study all patients in BC with SLE and RA who have been on hydroxychloroquine (HCQ) for at least 5 years and follow them for 5 years to determine the ‘real risk’ of eye damage using state-of-the-art eye testing equipment for annual examinations. The overall goal of this study is to assess eye damage in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients who use hydroxychloroquine (HCQ), state-of-the-art eye testing equipment.

 

Who is involved?

The research team consist of researchers, rheumatologists, ophthalmologists and family physicians who are committed to deliver safe and appropriate care to the population.

 

Co-Principal Investigator

John Esdaile – MD, MPH, FRCPC Scientific Director, Arthritis Research Canada; Professor of Medicine, Division of Rheumatology, University of British Columbia

 

Co-Investigators

Hyon Choi, MD, DrPH, FRCPC Professor of Medicine, Massachusetts General Hospital, Harvard Medical School Linda Li, BSc(PT), MSc, PhD Senior Research Scientist, Arthritis Research Canada; Associate Professor, Department of Physical Therapy, University of British Columbia

Hui Xie, PhD Professor, Faculty of Health Sciences, Simon Fraser University

Diane Lacaille, MD, MHSc, FRCPC Senior Research Scientist of Rheumatology, Professor and Associate Head Academic Affairs, Division of Rheumatology, Department of Medicine, University of British Columbia

Kamran Shojania, MD, FRCPC Clinical Trialist and former Director of Clinical Trials

Mahyar Etminan, PharmD, MSc Assistant Professor of Ophthalmology and Visual Sciences, Faculty of Medicine, University of British Columbia, The Eye Care Center

Dr. David Maberley, MD Professor, Department of Ophthalmology and Visual Sciences

Martin Dawes, MB.BS, MD., FRCGP Royal Canadian Legion Professor, Head, Department of Family Practice, University of British Columbia,

 

Collaborators

Alison Hoens, PT, KB, BC Support Unit Cheryl Koehn, President, Arthritis Consumer Experts

 

Research Staff

Dami Ojo, M.P.H., Research Assistant, Arthritis Research Canada

 

Who is funding this research?

Canadian Institutes of Health Research

[gravityform id=4 title=false ajax=true]
<div class='gf_browser_unknown gform_wrapper gravity-theme' id='gform_wrapper_4' ><div id='gf_4' class='gform_anchor' tabindex='-1'></div> <div class='gform_heading'> <span class='gform_description'></span> </div><form method='post' enctype='multipart/form-data' target='gform_ajax_frame_4' id='gform_4' action='/research/risk-of-retinal-toxicity-in-patients-with-systemic-lupus-erythematosus-and-rheumatoid-arthritis-on-long-term-hydroxychloroquine-therapy-2/#gf_4' novalidate> <div class='gform_body gform-body'><div id='gform_fields_4' class='gform_fields top_label form_sublabel_below description_below'><div id="field_4_1" class="gfield gfield_contains_required field_sublabel_below field_description_below hidden_label gfield_visibility_visible" ><label class='gfield_label' for='input_4_1' >First Name<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_text'><input name='input_1' id='input_4_1' type='text' value='' class='large' placeholder='First Name' aria-required="true" aria-invalid="false" /> </div></div><div id="field_4_2" class="gfield gfield_contains_required field_sublabel_below field_description_below hidden_label gfield_visibility_visible" ><label class='gfield_label' for='input_4_2' >Last Name<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_text'><input name='input_2' id='input_4_2' type='text' value='' class='large' placeholder='Last Name' aria-required="true" aria-invalid="false" /> </div></div><div id="field_4_3" class="gfield gfield_contains_required field_sublabel_below field_description_below hidden_label gfield_visibility_visible" ><label class='gfield_label' for='input_4_3' >Email<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_email'> <input name='input_3' id='input_4_3' type='email' value='' class='large' placeholder='Email Address' aria-required="true" aria-invalid="false" /> </div></div></div></div> <div class='gform_footer top_label'> <input type='submit' id='gform_submit_button_4' class='gform_button button' value='Subscribe' onclick='if(window["gf_submitting_4"]){return false;} if( !jQuery("#gform_4")[0].checkValidity || jQuery("#gform_4")[0].checkValidity()){window["gf_submitting_4"]=true;} ' onkeypress='if( event.keyCode == 13 ){ if(window["gf_submitting_4"]){return false;} if( !jQuery("#gform_4")[0].checkValidity || jQuery("#gform_4")[0].checkValidity()){window["gf_submitting_4"]=true;} jQuery("#gform_4").trigger("submit",[true]); }' /> <input type='hidden' name='gform_ajax' value='form_id=4&amp;title=&amp;description=1&amp;tabindex=0' /> <input type='hidden' class='gform_hidden' name='is_submit_4' value='1' /> <input type='hidden' class='gform_hidden' name='gform_submit' value='4' /> <input type='hidden' class='gform_hidden' name='gform_unique_id' value='' /> <input type='hidden' class='gform_hidden' name='state_4' value='WyJbXSIsIjBkMjRlYjFkM2FlNTc1OTE5MDU0MTVkNzE4YjNjMjdlIl0=' /> <input type='hidden' class='gform_hidden' name='gform_target_page_number_4' id='gform_target_page_number_4' value='0' /> <input type='hidden' class='gform_hidden' name='gform_source_page_number_4' id='gform_source_page_number_4' value='1' /> <input type='hidden' name='gform_field_values' value='' /> </div> </form> </div> <iframe style='display:none;width:0px;height:0px;' src='about:blank' name='gform_ajax_frame_4' id='gform_ajax_frame_4' title='This iframe contains the logic required to handle Ajax powered Gravity Forms.'></iframe> <script type="text/javascript"> gform.initializeOnLoaded( function() {gformInitSpinner( 4, 'https://www.arthritisresearch.ca/wp-content/plugins/gravityforms/images/spinner.svg' );jQuery('#gform_ajax_frame_4').on('load',function(){var contents = jQuery(this).contents().find('*').html();var is_postback = contents.indexOf('GF_AJAX_POSTBACK') >= 0;if(!is_postback){return;}var form_content = jQuery(this).contents().find('#gform_wrapper_4');var is_confirmation = jQuery(this).contents().find('#gform_confirmation_wrapper_4').length > 0;var is_redirect = contents.indexOf('gformRedirect(){') >= 0;var is_form = form_content.length > 0 && ! is_redirect && ! is_confirmation;var mt = parseInt(jQuery('html').css('margin-top'), 10) + parseInt(jQuery('body').css('margin-top'), 10) + 100;if(is_form){jQuery('#gform_wrapper_4').html(form_content.html());if(form_content.hasClass('gform_validation_error')){jQuery('#gform_wrapper_4').addClass('gform_validation_error');} else {jQuery('#gform_wrapper_4').removeClass('gform_validation_error');}setTimeout( function() { /* delay the scroll by 50 milliseconds to fix a bug in chrome */ jQuery(document).scrollTop(jQuery('#gform_wrapper_4').offset().top - mt); }, 50 );if(window['gformInitDatepicker']) {gformInitDatepicker();}if(window['gformInitPriceFields']) {gformInitPriceFields();}var current_page = jQuery('#gform_source_page_number_4').val();gformInitSpinner( 4, 'https://www.arthritisresearch.ca/wp-content/plugins/gravityforms/images/spinner.svg' );jQuery(document).trigger('gform_page_loaded', [4, current_page]);window['gf_submitting_4'] = false;}else if(!is_redirect){var confirmation_content = jQuery(this).contents().find('.GF_AJAX_POSTBACK').html();if(!confirmation_content){confirmation_content = contents;}setTimeout(function(){jQuery('#gform_wrapper_4').replaceWith(confirmation_content);jQuery(document).scrollTop(jQuery('#gf_4').offset().top - mt);jQuery(document).trigger('gform_confirmation_loaded', [4]);window['gf_submitting_4'] = false;wp.a11y.speak(jQuery('#gform_confirmation_message_4').text());}, 50);}else{jQuery('#gform_4').append(contents);if(window['gformRedirect']) {gformRedirect();}}jQuery(document).trigger('gform_post_render', [4, current_page]);} );} ); </script>