John Esdaile

Scientific Director Emeritus, MD, MPH, FRCPC, FCAHS, MACR



  • Professor Emeritus, Division of Rheumatology, Department of Medicine, University of British Columbia
  • Adjunct Professor of Medicine, University of Calgary


Research Interests

  • Rheumatology
  • Osteoarthritis
  • Systemic lupus erythematosus


Dr. John Esdaile is an internationally respected rheumatologist who spearheaded the creation of Arthritis Research Canada.

He completed his undergraduate medical training at McGill University in Montreal, P.Q., and went on to post-graduate training in Montreal, Toronto, and London, England. He returned to the Montreal General Hospital where he was responsible for setting up a clinical post-graduate program in rheumatology. He subsequently went on to study under Alvan R. Feinstein of the Robert Wood Johnson Clinical Scholar’s Program at the Yale University School of Medicine and to obtain a Master’s of Public Health Degree from Yale.

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Upon his return to McGill University, Dr. Esdaile was named Director of Rheumatology, initially at the Montreal General Hospital and subsequently for the University. He played a key role in the rapid expansion and success of the Clinical Epidemiology Unit at the Montreal General Hospital. Over the ensuing decade, the clinical epidemiology group grew from a tenure track faculty of four to more than a dozen faculty members with a total staff of 50.

In 1996, Dr. Esdaile accepted the positions of Head of Rheumatology at the University of British Columbia and Director of Research at The Arthritis Society, BC & Yukon Division. Dedicated to expanding Canada’s role in arthritis research, Dr. Esdaile was largely responsible for developing and establishing Arthritis Research Canada, of which he was named Scientific Director.

Dr. Esdaile has authored more than 250 publications in refeered journals, as well as more than two dozen books and book chapters. As one of five principal investigators, Dr. Esdaile was successful in receiving funding for the Canadian Arthritis Network, a federally funded Networks of Centres of Excellence, providing more than $40 million over ten years for arthritis research. This grant involves more than 150 scientists from across Canada, including many from BC.

Dr. Esdaile’s areas of research interest include rheumatoid arthritis, osteoarthritis and systemic lupus erythematosus. His publication of the efficacy of hydroxychloroquine in systemic lupus erythematosus is considered a landmark paper that has altered the treatment of this disease for many patients.

Dr. Esdaile received the Distinguished Investigator Award at the 2005 Canadian Rheumatology Association meetings in Quebec.  In 2006, he was named a Kirkland Scholar by the Kirkland Foundation in New York, NY and in 2007 he was elected a Fellow of the Canadian Academy of Health Sciences. In 2012, Dr. Esdaile received a Master Designation from the American College of Rheumatology, which is one of the highest honors the college bestows to members who have made outstanding contributions to the field of rheumatology. And in 2013 he received the Jonas Salk award for lifetime achievement, Sanofi Pasteur and March of Dimes.


Abrahamowicz M, Esdaile JM, Ramsey-Goldman R, Simon LS, Strand V, Lipsky PE. Development and Validation of a Novel Evidence-Based Lupus Multivariable Outcome Score for Clinical Trials. Arthritis Rheumatol. 2018 Apr 12. doi: 10.1002/art.40522. [Epub ahead of print]. PubMed PMID: 29648686. https://www.ncbi.nlm.nih.gov/pubmed/29648686


Cibere J, Guermazi A, Nicolaou S, Esdaile JM, Thorne A, Singer J, Wong H, Kopec JA, Sayre EC. Association of physical examination knee effusion with bone marrow lesions: cross-sectional and longitudinal analyses of a population-based cohort. Arthritis Care & Research. Accepted. PubMed PMID: 29648685. https://www.ncbi.nlm.nih.gov/pubmed/29648685


Schmidt TJ, Aviña-Zubieta JA, Sayre EC, Abrahamowicz M, Esdaile JM, Lacaille D. Quality of care for cardiovascular disease prevention in rheumatoid arthritis: Compliance with hyperlipidemia screening guidelines. March 2018. Rheumatology (Oxford). Accepted.


Schmidt TJ, Aviña-Zubieta JA, Sayre EC, Abrahamowicz M, Esdaile JM, Lacaille, D. Quality of Care for cardiovascular disease Prevention in RA: Compliance with Diabetes Screening Guidelines. J Rheumatol. March 2018, Accepted.


Keng A, Sayre EC, Guermazi A, Nicolaou S, Esdaile JM, Thorne A, Singer J, Kopec JA, Cibere J. Association of body mass index with knee cartilage damage in an asymptomatic population-based study. BMC Musculoskelet Dirord. 2017 Dec 8;18(`):517. PubMed PMID: 29221481. https://www.ncbi.nlm.nih.gov/pubmed/29221481


Guo YZ, Zhang H, Qian H, Wilson D, Wong H, Barber M, Forster B, Esdaile J, Cibere J. The association of femoroacetabular impingement and delayed gadolinium enhanced MRI of cartilage (DGEMRIC): a population-based study. Arthritis Care Res (Hoboken). 2017 Nov 7. doi: 10.1002/acr.23463. [Epub ahead of print]. PubMed PMID: 29112800. https://www.ncbi.nlm.nih.gov/pubmed/29112800


Simon TA, Kawabata H, Ray N, Baheti A, Suissa S, Esdaile JM. Prevalence of co-existing autoimmune disease in rheumatoid arthritis: a cross-sectional study. Adv Ther. 2017; 34(11): 2481–2490. PubMed PMID: 29067557. https://www.ncbi.nlm.nih.gov/pubmed/29067557


McGuire K, Avina-Zubieta JA, Sayre EC, Abrahamowicz M, Esdaile JM, Lacaille D. Risk of incident chronic obstructive pulmonary disease (COPD) in rheumatoid arthritis: a population based cohort study. Arthritis Care Res. 2017 Oct 19. doi: 10.1002/acr.23410. [Epub ahead of print] PubMed PMID: 29047218. https://www.ncbi.nlm.nih.gov/pubmed/29047218


Estrada A, Tsao NW, Howren A, Esdaile JM, Shojania K, De Vera MA. Utility of electronic medical records in community rheumatology practice for assessing quality of care Indicators for gout: a feasibility study.J Clin Rheumatol. 2018 Mar;24(2):75-79. PubMed PMID: 29232325. https://www.ncbi.nlm.nih.gov/pubmed/29232325


Sayre EC, Guermazi A, Esdaile JM, Kopec JA, Singer J, Thorne A, Nicolaou S, Cibere J. Associations between MRI features versus knee pain severity and progression: Data from the Vancouver Longitudinal Study of Early Knee Osteoarthritis. PLoS One. 2017 May 4;12(5):e0176833. doi: 10.1371/journal.pone.0176833. eCollection 2017. PubMed PMID: 28472071; PubMed Central PMCID: PMC5417516. https://www.ncbi.nlm.nih.gov/pubmed/28472071


Kopec JA, Cibere J, Li LC, Zhang C, Barber M, Qian H, Wong H, Steininger G, Prlic H, Simatovic J, Ratzlaff C, Sayre EC, Ye J, Forster BB, Esdaile JM, On behalf of the IMPAKT-HIP Study Team. Relationship between physical activity and hip pain in persons with and without cam or pincer morphology: a population-based case-control study. Osteoarthritis Cartilage. 2017 Feb 20. pii: S1063-4584(17)30862-2. [Epub ahead of print]. https://www.ncbi.nlm.nih.gov/pubmed/28219714


Tan JA, Dehghan N, Chen W, Xie H, Esdaile JM, Avina-Zubieta JA. Mortality in ANCA-associated vasculitis: a meta-analysis of observational studies. Ann Rheum Dis. 2017 May 3. pii: annrheumdis-2016-210942. doi: 10.1136/annrheumdis-2016-210942. [Epub ahead of print] PubMed PMID: 28468793. https://www.ncbi.nlm.nih.gov/pubmed/28468793


Aviña-Zubieta JA, To F, Vostretsova K, De Vera M, Sayre EC, Esdaile JM. Risk of Myocardial Infarction and Stroke in Newly Diagnosed Systemic Lupus Erythematosus: A General Population-Based Study. Arthritis Care Res (Hoboken). 2017 Jun;69(6):849-856. doi: 10.1002/acr.23018. Epub 2017 May 9. PubMed PMID: 28129475. https://www.ncbi.nlm.nih.gov/pubmed/28129475


Mehat P, Atiquzzaman M, Esdaile JM, Avina-Zubieta A, De Vera MA. Medication Non-Adherence in Systemic Lupus Erythematosus: A Systematic Review. Arthritis Care Res (Hoboken). 2017 Jan 13. doi: 10.1002/acr.23191. [Epub ahead of print] PubMed PMID: 28086003. https://www.ncbi.nlm.nih.gov/pubmed/28086003


Barber CE, Esdaile JM, Martin LO, Faris P, Barnabe C, Guo S, Lopatina E, Marshall DA. Gaps in Addressing Cardiovascular Risk in Rheumatoid Arthritis: Assessing Performance Using Cardiovascular Quality Indicators. J Rheumatol. 2016 Nov;43(11):1965-1973. Epub 2016 Aug 1. PubMed PMID: 27481908. https://www.ncbi.nlm.nih.gov/pubmed/27481908


Khodyakov D, Grant S, Barber CE, Marshall DA, Esdaile JM, Lacaille D. Acceptability of an online modified Delphi panel approach for developing health services performance measures: results from 3 panels on arthritis research. J Eval Clin Pract. 2017 Apr;23(2):354-360. doi: 10.1111/jep.12623. Epub 2016 Sep 13. PubMed PMID: 27619536. https://www.ncbi.nlm.nih.gov/pubmed/27619536


Barnabe C, Jones CA, Bernatsky S, Peschken CA, Voaklander D, Homik J, Crowshoe LF, Esdaile JM, El-Gabalawy H, Hemmelgarn B. Inflammatory Arthritis Prevalence and Health Services Use in the First Nations and Non-First Nations Populations of Alberta, Canada. Arthritis Care Res (Hoboken). 2017 Apr;69(4):467-474. doi: 10.1002/acr.22959. Epub 2017 Mar 9. PubMed PMID: 27333120. https://www.ncbi.nlm.nih.gov/pubmed/27333120


Ratzlaff C, Zhang C, Korzan J, Josey L, Wong H, Cibere J, Prlic HM, Kopec JA, Esdaile JM, Li LC, Barber M, Forster BB. The validity of a non-radiologist reader in identifying cam and pincer femoroacetabular impingement (FAI) using plain radiography. Rheumatol Int. 2016 Mar;36(3):371-6. https://www.ncbi.nlm.nih.gov/pubmed/26433895


Ware MA, Wang T, Shapiro S, Collet JP; COMPASS study team. Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS). J Pain. 2015 J Pain. 2015 Dec;16(12):1233-42. https://www.ncbi.nlm.nih.gov/pubmed/26385201


Zhang C, Li L, Forster BB, Kopec JA, Ratzlaff C, Halai L, Cibere J, Esdaile JM. Femoroacetabular impingement and osteoarthritis of the hip. Can Fam Physician. 2015 Dec;61(12):1055-60. PubMed PMID: 26668284; PubMed Central PMCID: PMC4677941. https://www.ncbi.nlm.nih.gov/pubmed/26668284


Hung A, Sayre EC, Guermazi A, Esdaile JM, Kopec JA, Thorne A, Singer J, Wong H, Nicolaou S, Cibere J. Association of Body Mass Index With Incidence and Progression of Knee Effusion on Magnetic Resonance Imaging and on Knee Examination. Arthritis Care Res (Hoboken). 2016 Apr;68(4):511-6. doi: 10.1002/acr.22714. PubMed PMID: 26359653. https://www.ncbi.nlm.nih.gov/pubmed/26359653


Barber CE, Marshall DA, Alvarez N, Mancini GB, Lacaille D, Keeling S, Aviña-Zubieta JA, Khodyakov D, Barnabe C, Faris P, Smith A, Noormohamed R, Hazlewood G, Martin LO, Esdaile JM; Quality Indicator International Panel. Development of Cardiovascular Quality Indicators for Rheumatoid Arthritis: Results from an International Expert Panel Using a Novel Online Process. J Rheumatol. 2015 Sep;42(9):1548-55. doi: 10.3899/jrheum.141603. Epub 2015 Jul 15. PubMed PMID: 26178275; PubMed Central PMCID: PMC4758831. https://www.ncbi.nlm.nih.gov/pubmed/26178275


Kopec JA, Sayre EC, Rogers P, Davis AM, Badley EM, Anis AH, Abrahamowicz M, Russell L, Rahman MM, Esdaile JM. Multiattribute health utility scoring for the computerized adaptive measure CAT-5D-QOL was developed and validated. J Clin Epidemiol. 2015 Oct;68(10):1213-20.e1-6. doi: 10.1016/j.jclinepi.2015.03.020. Epub 2015 Apr 14. PubMed PMID: 25990544. https://www.ncbi.nlm.nih.gov/pubmed/25990544


Zong JY, Leese J, Klemm A, Sayre EC, Memetovic J, Esdaile JM, Li LC. Rheumatologists’ Views and Perceived Barriers to Using Patient Decision Aids in Clinical Practice. Arthritis Care Res (Hoboken). 2015 Oct;67(10):1463-70. doi: 10.1002/acr.22605. PubMed PMID: 25941019. https://www.ncbi.nlm.nih.gov/pubmed/25941019


Barnabe C, Hemmelgarn B, Jones CA, Peschken CA, Voaklander D, Joseph L, Bernatsky S, Esdaile JM, Marshall DA. Imbalance of prevalence and specialty care for osteoarthritis for first nations people in Alberta, Canada. J Rheumatol. 2015 Feb;42(2):323-8. doi: 10.3899/jrheum.140551. Epub 2014 Nov 29. PubMed PMID: 25433531. https://www.ncbi.nlm.nih.gov/pubmed/25433531


Barber CE, Smith A, Esdaile JM, Barnabe C, Martin LO, Faris P, Hazlewood G, Noormohamed R, Alvarez N, Mancini GB, Lacaille D, Keeling S, Aviña-Zubieta JA, Marshall D. Best practices for cardiovascular disease prevention in rheumatoid arthritis: a systematic review of guideline recommendations and quality indicators. Arthritis Care Res (Hoboken). 2015 Feb;67(2):169-79. doi: 10.1002/acr.22419. Review. PubMed PMID: 25074725. https://www.ncbi.nlm.nih.gov/pubmed/25074725


Carruthers EC, Rogers P, Backman CL, Goldsmith CH, Gignac MA, Marra C, Village J, Li LC, Esdaile JM, Lacaille D. “Employment and arthritis: making it work” a randomized controlled trial evaluating an online program to help people with inflammatory arthritis maintain employment (study protocol). BMC Med Inform Decis Mak. 2014 Jul 21;14:59. doi: 10.1186/1472-6947-14-59. PubMed PMID: 25043631; PubMed Central PMCID: PMC4123503. https://www.ncbi.nlm.nih.gov/pubmed/25043631


Crema MD, Cibere J, Sayre EC, Roemer FW, Wong H, Thorne A, Singer J, Esdaile JM, Marra MD, Kopec JA, Nicolaou S, Guermazi A. The relationship between subchondral sclerosis detected with MRI and cartilage loss in a cohort of subjects with knee pain: the knee osteoarthritis progression (KOAP) study. Osteoarthritis Cartilage. 2014 Apr;22(4):540-6. https://www.ncbi.nlm.nih.gov/pubmed/24508776


Marra CA, Grubisic M, Cibere J, Grindrod KA, Woolcott JC, Gastonguay L, Esdaile JM. Cost-utility analysis of a multidisciplinary strategy to manage osteoarthritis of the knee: economic evaluation of a cluster randomized controlled trial study. Arthritis Care Res (Hoboken). 2014 Jun;66(6):810-6. doi: 10.1002/acr.22232. PubMed PMID: 24249680. https://www.ncbi.nlm.nih.gov/pubmed/24249680


Ratzlaff C, Simatovic, J, Wong H., Li L, Ezzat E, Esdaile J, Langford DP, Kennedy C, Embley P. Caves DF, Hopkins T, Cibere J. Reliability of hip examination tests for femoroacetabular impingement. Arthritis Care and Res 2013;65(10):1690-6. https://www.ncbi.nlm.nih.gov/pubmed/23609994


Davis EM, Lynd LD, Grubisic M, Kopec JA, Sayre EC, Cibere J, Esdaile J, Marra CA. Responsiveness of health state utility values in knee osteoarthritis. J Rheumatol. 2013 Dec;40(12):2075-82. doi: 10.3899/jrheum.130176. Epub 2013 Nov 1. PubMed PMID: 24187098. https://www.ncbi.nlm.nih.gov/pubmed/24187098


Sayre EC, Singer J, Thorne A, Wong H, Kopec JA, Esdaile JM, Guermazi A, Nicolaou S, Cibere J. Does moderate or severe nonspecific knee injury affect radiographic osteoarthritis incidence and progression? BMC Musculoskelet Disord. 2013 Oct 28;14:309. doi: 10.1186/1471-2474-14-309. PubMed PMID: 24164716; PubMed Central PMCID: PMC4231427. https://www.ncbi.nlm.nih.gov/pubmed/24164716


Stephenson E, Delongis A, Esdaile JM, Lehman AJ. Depressive symptoms and rheumatoid arthritis: spouse empathic responding as a buffer. Arthritis Care Res (Hoboken). 2014 Apr;66(4):532-41. doi: 10.1002/acr.22161. PubMed PMID: 24023009. https://www.ncbi.nlm.nih.gov/pubmed/24023009


Bourré-Tessier J, Peschken CA, Bernatsky S, Joseph L, Clarke AE, Fortin PR, Hitchon C, Mittoo S, Smith CD, Zummer M, Pope J, Tucker L, Hudson M, Arbillaga H, Esdaile J, Silverman E, Chédeville G, Huber AM, Belisle P; Canadian Network for Improved Outcomes in Systemic Lupus Erythematosus 1000 Canadian Faces of Lupus Investigators, Pineau CA. Association of smoking with cutaneous manifestations in systemic lupus erythematosus. Arthritis Care Res 2013;65(8):1275-80. https://www.ncbi.nlm.nih.gov/pubmed/23401335


Li LC, Lineker S, Cibere J, Crooks VA, Jones CA, Kopec JA, Lear SA, Pencharz J, Rhodes RE, Esdaile JM. Capitalizing on the teachable moment: osteoarthritis physical activity and exercise net for improving physical activity in early knee osteoarthritis. JMIR Res Protoc. 2013 May 9;2(1):e17. doi: 10.2196/resprot.2553. PubMed PMID: 23659903; PubMed Central PMCID: PMC3650932. https://www.ncbi.nlm.nih.gov/pubmed/23659903


Kopec JA, Sayre EC, Davis AM, Badley EM, Abrahamowicz M, Pouchot J, Sherlock L, Esdaile JM. Development of a paper-and-pencil semi-adaptive questionnaire for 5 domains of health-related quality of life (PAT-5D-QOL). Qual Life Res. 2013 Dec;22(10):2829-42. doi: 10.1007/s11136-013-0419-4. Epub 2013 May 8. PubMed PMID: 23653158. https://www.ncbi.nlm.nih.gov/pubmed/23653158


Barber CE, Kim J, Inman RD, Esdaile JM, James MT. Antibiotics for treatment of reactive arthritis: a systematic review and metaanalysis. J Rheumatol. 2013 Jun;40(6):916-28. doi: 10.3899/jrheum.121192. Epub 2013 Apr 15. Review. PubMed PMID: 23588936. https://www.ncbi.nlm.nih.gov/pubmed/23588936


Aviña-Zubieta JA, Abrahamowicz M, De Vera MA, Choi HK, Sayre EC, Rahman MM, Sylvestre MP, Wynant W, Esdaile JM, Lacaille D. Immediate and past cumulative effects of oral glucocorticoids on the risk of acute myocardial infarction in rheumatoid arthritis: a population-based study. Rheumatology (Oxford). 2013 Jan;52(1):68-75. doi: 10.1093/rheumatology/kes353. Epub 2012 Nov 28. PubMed PMID: 23192907. https://www.ncbi.nlm.nih.gov/pubmed/23192907


Marra CA, Cibere J, Grubisic M, Grindrod KA, Gastonguay L, Thomas JM, Embley P, Colley L, Tsuyuki RT, Khan KM, Esdaile JM. Pharmacist-initiated intervention trial in osteoarthritis: a multidisciplinary intervention for knee osteoarthritis. Arthritis Care Res (Hoboken). 2012 Dec;64(12):1837-45. doi: 10.1002/acr.21763. PubMed PMID: 22930542. https://www.ncbi.nlm.nih.gov/pubmed/22930542


Lung R, O’Brien J, Grebenyuk J, Forster BB, De Vera M, Kopec J, Ratzlaff C, Garbuz D, Prlic H, Esdaile JM. The prevalence of radiographic femoroacetabular impingement in younger individuals undergoing total hip replacement for osteoarthritis. Clin Rheumatol. 2012 Aug;31(8):1239-42. doi: 10.1007/s10067-012-1981-9. Epub 2012 May 3. PubMed PMID: 22552857. https://www.ncbi.nlm.nih.gov/pubmed/22552857


Karp I, Abrahamowicz M, Fortin PR, Pilote L, Neville C, Pineau CA, Esdaile JM. Longitudinal evolution of risk of coronary heart disease in systemic lupus erythematosus. J Rheumatol. 2012 May;39(5):968-73. doi: 10.3899/jrheum.111127. Epub 2012 Apr 1. PubMed PMID: 22467935. https://www.ncbi.nlm.nih.gov/pubmed/22467935


Marra CA, Lynd LD, Colley L, Harvard SS, Lacaille D, Schwenger E, Anis AH, Esdaile JM. Risk of gastrointestinal events in patients with rheumatoid arthritis after withdrawal of rofecoxib. J Rheumatol. 2012 May;39(5):910-5. doi: 10.3899/jrheum.110604. Epub 2012 Mar 15. PubMed PMID: 22422500. https://www.ncbi.nlm.nih.gov/pubmed/22422500


Wiwatwongwana D, Esdaile JM, White VA, Dolman PJ. Intravenous immunoglobulin (IVIG) for orbital Wegener’s granulomatosis. Can J Ophthalmol. 2012 Feb;47(1):82-3. doi: 10.1016/j.jcjo.2011.12.007. PubMed PMID: 22333859. https://www.ncbi.nlm.nih.gov/pubmed/22333859


Crema MD, Guermazi A, Sayre EC, Roemer FW, Wong H, Thorne A, Singer J, Esdaile JM, Marra MD, Kopec JA, Nicolaou S, Cibere J. The association of magnetic resonance imaging (MRI)-detected structural pathology of the knee with crepitus in a population-based cohort with knee pain: the MoDEKO study.  Osteoarthritis Cartilage 2011;19(12):1429-32. https://www.ncbi.nlm.nih.gov/pubmed/21945851


Li LC, Sayre EC, Kopec JA, Esdaile JM, Bar S, Cibere J. Quality of nonpharmacological care in the community for people with knee and hip osteoarthritis. J Rheumatol. 2011 Oct;38(10):2230-7. doi: 10.3899/jrheum.110264. Epub 2011 Aug 1. PubMed PMID: 21807776. https://www.ncbi.nlm.nih.gov/pubmed/21807776


Cibere J, Sayre EC, Guermazi A, Nicolaou S, Kopec JA, Esdaile JM, Thorne A, Singer J, Wong H. Natural history of cartilage damage and osteoarthritis progression on magnetic resonance imaging in a population-based cohort with knee pain. Osteoarthritis Cartilage 2011;19(6):683-8. https://www.ncbi.nlm.nih.gov/pubmed/21329760


Aviña-Zubieta JA, Abrahamowicz M, Choi HK, Rahman MM, Sylvestre MP, Esdaile JM, Lacaille D. Risk of cerebrovascular disease associated with the use of glucocorticoids in patients with incident rheumatoid arthritis: a population-based study. Ann Rheum Dis. 2011 Jun;70(6):990-5. doi: 10.1136/ard.2010.140210. Epub 2011 Mar 2. PubMed PMID: 21367762. https://www.ncbi.nlm.nih.gov/pubmed/21367762


Ip S, Sayre EC, Guermazi A, Nicolaou S, Wong H, Thorne A, Singer J, Kopec JA, Esdaile JM, Cibere J. Frequency of bone marrow lesions and association with pain severity: results from a population-based symptomatic knee cohort. J Rheumatol. 2011 Jun;38(6):1079-85. doi: 10.3899/jrheum.100587. Epub 2011 Mar 1. PubMed PMID: 21362771. https://www.ncbi.nlm.nih.gov/pubmed/21362771


Ratzlaff C, Steininger G, Doerfling P, Koehoorn M, Cibere J, Liang M, Wilson D, Esdaile J, Kopec J. Influence of lifetime hip joint force on the risk of self-reported hip osteoarthritis: a community-based cohort study.  Osteoarthritis Cartilage 2011;19:389-98. https://www.ncbi.nlm.nih.gov/pubmed/21255666


Doerfling P, Kopec JA, Liang MH, Esdaile JM. The effect of cash lottery on response rates to an online health survey among members of the Canadian Association of Retired Persons: a randomized experiment. Can J Public Health. 2010 May-Jun;101(3):251-4. PubMed PMID: 20737820. https://www.ncbi.nlm.nih.gov/pubmed/20737820


Lehman AJ, Pratt DD, DeLongis A, Collins JB, Shojania K, Koehler B, Offer R, Esdaile JM. Do spouses know how much fatigue, pain, and physical limitation their partners with rheumatoid arthritis experience? Implications for social support. Arthritis Care Res (Hoboken). 2011 Jan;63(1):120-7. doi: 10.1002/acr.20330. PubMed PMID: 20722040. https://www.ncbi.nlm.nih.gov/pubmed/20722040


Cibere J, Zhang H, Thorne A, Wong H, Singer J, Kopec JA, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Association of clinical findings with pre-radiographic and radiographic knee osteoarthritis in a population-based study. Arthritis Care Res (Hoboken). 2010 Dec;62(12):1691-8. doi: 10.1002/acr.20314. Epub 2010 Jul 27. PubMed PMID: 20665737. https://www.ncbi.nlm.nih.gov/pubmed/20665737


Ratzlaff CR, Doerfling P, Steininger G, Koehoorn M, Cibere J, Liang M, Wilson DR, Esdaile J, Kopec J. Lifetime trajectory of physical activity according to energy expenditure and joint force. Arthritis Care Res (Hoboken). 2010 Oct;62(10):1452-9. doi: 10.1002/acr.20243. PubMed PMID: 20506184. https://www.ncbi.nlm.nih.gov/pubmed/20506184


Sayre EC, Li LC, Kopec JA, Esdaile JM, Bar S, Cibere J. The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis. PLoS One. 2010 May 3;5(5):e10470. doi: 10.1371/journal.pone.0010470. PubMed PMID: 20454665; PubMed Central PMCID: PMC2862713. https://www.ncbi.nlm.nih.gov/pubmed/20454665


Grindrod KA, Marra CA, Colley L, Cibere J, Tsuyuki RT, Esdaile JM, Gastonguay L, Kopec J. After patients are diagnosed with knee osteoarthritis, what do they do? Arthritis Care Res (Hoboken). 2010 Apr;62(4):510-5. doi: 10.1002/acr.20170. PubMed PMID: 20391506. https://www.ncbi.nlm.nih.gov/pubmed/20391506


Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, Kraus VB, Way A, Thorne A, Wong H, Singer J, Kopec J, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. Arthritis Rheum. 2009 May;60(5):1372-80. doi: 10.1002/art.24473. PubMed PMID: 19404937; PubMed Central PMCID: PMC4724193. https://www.ncbi.nlm.nih.gov/pubmed/19404937


Aviña-Zubieta JA, Choi HK, Sadatsafavi M, Etminan M, Esdaile JM, Lacaille D. Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies. Arthritis Rheum. 2008 Dec 15;59(12):1690-7. doi: 10.1002/art.24092. PubMed PMID: 19035419. https://www.ncbi.nlm.nih.gov/pubmed/19035419


Lacaille D, White MA, Rogers PA, Backman CL, Gignac MA, Esdaile JM. A proof-of-concept study of the “Employment and Arthritis: Making It Work” program. Arthritis Rheum. 2008 Nov 15;59(11):1647-55. doi: 10.1002/art.24197. PubMed PMID: 18975352. https://www.ncbi.nlm.nih.gov/pubmed/18975352


Lacaille D, Guh DP, Abrahamowicz M, Anis AH, Esdaile JM. Use of nonbiologic disease-modifying antirheumatic drugs and risk of infection in patients with rheumatoid arthritis. Arthritis Rheum. 2008 Aug 15;59(8):1074-81. doi: 10.1002/art.23913. PubMed PMID: 18668604. https://www.ncbi.nlm.nih.gov/pubmed/18668604


Koehn CL, Esdaile JM. Patient education and self-management of musculoskeletal diseases. Best Pract Res Clin Rheumatol. 2008 Jun;22(3):395-405. doi: 10.1016/j.berh.2008.02.006. Review. PubMed PMID: 18519095. https://www.ncbi.nlm.nih.gov/pubmed/18519095


Pouchot J, Kherani RB, Brant R, Lacaille D, Lehman AJ, Ensworth S, Kopec J, Esdaile JM, Liang MH. Determination of the minimal clinically important difference for seven fatigue measures in rheumatoid arthritis. J Clin Epidemiol. 2008 Jul;61(7):705-13. doi: 10.1016/j.jclinepi.2007.08.016. Epub 2008 Mar 21. PubMed PMID: 18359189; PubMed Central PMCID: PMC2486378. https://www.ncbi.nlm.nih.gov/pubmed/18359189


Goligher EC, Pouchot J, Brant R, Kherani RB, Aviña-Zubieta JA, Lacaille D, Lehman AJ, Ensworth S, Kopec J, Esdaile JM, Liang MH. Minimal clinically important difference for 7 measures of fatigue in patients with systemic lupus erythematosus. J Rheumatol. 2008 Apr;35(4):635-42. Epub 2008 Mar 1. PubMed PMID: 18322987. https://www.ncbi.nlm.nih.gov/pubmed/18322987


Cibere J, Thorne A, Bellamy N, Greidanus N, Chalmers A, Mahomed N, Shojania K, Kopec J, Esdaile JM. Reliability of the hip examination in osteoarthritis: effect of standardization. Arthritis Rheum. 2008 Mar 15;59(3):373-81. doi: 10.1002/art.23310. PubMed PMID: 18311750. https://www.ncbi.nlm.nih.gov/pubmed/18311750


Karp I, Abrahamowicz M, Fortin PR, Pilote L, Neville C, Pineau CA, Esdaile  JM. Recent corticosteroid use and recent disease activity: independent determinants of coronary heart disease risk factors in systemic lupus erythematosus? Arthritis Rheum. 2008 Feb 15;59(2):169-75. doi: 10.1002/art.23352. PubMed PMID: 18240259. https://www.ncbi.nlm.nih.gov/pubmed/18240259


Marra CA, Cibere J, Tsuyuki RT, Soon JA, Esdaile JM, Gastonguay L, Oteng B, Embley P, Colley L, Enenajor G, Kok R. Improving osteoarthritis detection in the community: pharmacist identification of new, diagnostically confirmed osteoarthritis. Arthritis Rheum. 2007 Oct 15;57(7):1238-44. PubMed PMID: 17907209. https://www.ncbi.nlm.nih.gov/pubmed/17907209


Al-Herz A, Snip JP, Clark B, Esdaile JM. Exercise therapy for patients with diffuse idiopathic skeletal hyperostosis. Clin Rheumatol. 2008 Feb;27(2):207-10. Epub 2007 Sep 21. PubMed PMID: 17885726. https://www.ncbi.nlm.nih.gov/pubmed/17885726


Marra CA, Marion SA, Guh DP, Najafzadeh M, Wolfe F, Esdaile JM, Clarke AE, Gignac MA, Anis AH. Not all “quality-adjusted life years” are equal. J Clinical Epidemiol 2007;60(6):616-24. https://www.ncbi.nlm.nih.gov/pubmed/17493521


Panopalis P, Petri M, Manzi S, Isenberg DA, Gordon C, Senécal JL, Penrod JR, Joseph L, St Pierre Y, Pineau C, Fortin PR, Sutcliffe N, Goulet JR, Choquette D, Grodzicky T, Esdaile JM, Clarke AE; Tri-Nation Study Group. The systemic lupus erythematosus Tri-Nation study: cumulative indirect costs. Arthritis Rheum. 2007 Feb 15;57(1):64-70. PubMed PMID: 17266095. https://www.ncbi.nlm.nih.gov/pubmed/17266095


Li X, Guh D, Lacaille D, Esdaile J, Anis AH. The impact of cost sharing of prescription drug expenditures on health care utilization by the elderly: own-and cross-price elasticities. Health Policy. 2007 Aug;82(3):340-7. Epub 2006 Nov 28. PubMed PMID: 17134787. https://www.ncbi.nlm.nih.gov/pubmed/17134787


Kur JK, Esdaile JM. Posterior reversible encephalopathy syndrome—an underrecognized manifestation of systemic lupus erythematosus. J Rheumatol. 2006 Nov;33(11):2178-83. Epub 2006 Sep 1. Review. PubMed PMID: 16960925. https://www.ncbi.nlm.nih.gov/pubmed/16960925


Tan MC, Regier DA, Esdaile JM, Lynd LD, Anis AH, Marra CA. Health economic evaluation: a primer for the practicing rheumatologist. Arthritis Rheum. 2006 Aug 15;55(4):648-56. Review. PubMed PMID: 16874788. https://www.ncbi.nlm.nih.gov/pubmed/16874788


Kopec JA, Sayre EC, Davis AM, Badley EM, Abrahamowicz M, Sherlock L, Williams JI, Anis AH, Esdaile JM. Assessment of health-related quality of life in arthritis: conceptualization and development of five item banks using item response theory. Health Qual Life Outcomes. 2006 Jun 2;4:33. PubMed PMID: 16749932; PubMed Central PMCID: PMC1550394. https://www.ncbi.nlm.nih.gov/pubmed/16749932


Al-Harthy F, Esdaile J, Berean KW, Chalmers A. Multifocal idiopathic fibrosclerosis: treatment of 2 cases with cyclosporine. J Rheumatol. 2006 Feb;33(2):358-61. PubMed PMID: 16465670. https://www.ncbi.nlm.nih.gov/pubmed/16465670


Marra CA, Lynd LD, Anis AH, Esdaile JM. Approval process and access to prescription drugs in Canada. Arthritis Rheum. 2006 Feb 15;55(1):9-11. PubMed PMID: 16463404. https://www.ncbi.nlm.nih.gov/pubmed/16463404


Anis AH, Guh DP, Lacaille D, Marra CA, Rashidi AA, Li X, Esdaile JM. When patients have to pay a share of drug costs: effects on frequency of physician visits, hospital admissions and filling of prescriptions. CMAJ. 2005 Nov 22;173(11):1335-40. PubMed PMID: 16301701; PubMed Central PMCID: PMC1283500. https://www.ncbi.nlm.nih.gov/pubmed/16301701


Panopalis P, Petri M, Manzi S, Isenberg DA, Gordon C, Senecal JL, Penrod J, Joseph L, St. Pierre Y, Pineau C, Fortin PR, Sutcliffe N, Goulet JR, Choquette D, Grodzicky T, Esdaile JM, Clarke AE for the Tri-Nation Study Group. The systemic lupus erythematosus Tri-Nation study: Longitudinal changes in physical and mental well-being. Rheumatology 2005;44:751-5. https://www.ncbi.nlm.nih.gov/pubmed/15757968


Wong J, Esdaile JM. Methotrexate in systemic lupus erythematosus. Lupus 2005;14:101-5. https://www.ncbi.nlm.nih.gov/pubmed/15751813


Cibere J, Anona T, Kopec JA, Singer J, Canvin J, Robinson DB, Pope J, Hong P, Grant E, Ionescu M, Poole AR, Esdaile JM. Glucosamine sulfate and cartilage type II collagen degradation in patients with knee osteoarthritis: randomized discontinuation trial results employing biomarkers. J Rheumatol 2005;32:896-902. https://www.ncbi.nlm.nih.gov/pubmed/15868627


Marra CA, Rashidi AA, Guh D, Kopec JA, Abrahamowicz M, Esdaile JM, Brazier JE, Fortin PR, Anis AH. Are indirect utility measures reliable and responsive in rheumatoid arthritis patients? Qual Life Res. 2005 Jun;14(5):1333-44. PubMed PMID: 16047508. https://www.ncbi.nlm.nih.gov/pubmed/16047508


Lehman AJ, Esdaile JM, Klinkhoff AV, Grant E, Fitzgerald A, Canvin J; METGO Study Group. A 48-week, randomized, double-blind, double-observer, placebo-controlled multicenter trial of combination methotrexate and intramuscular gold therapy in rheumatoid arthritis: results of the METGO study. Arthritis Rheum. 2005 May;52(5):1360-70. PubMed PMID: 15880810. https://www.ncbi.nlm.nih.gov/pubmed/15880810


Cibere J, Thorne A, Kopec JA, Singer J, Canvin J, Robinson DB, Pope J, Hong P, Grant E, Lobanok T, Ionescu M, Poole AR, Esdaile JM. Glucosamine sulfate and cartilage type II collagen degradation in patients with knee osteoarthritis: randomized discontinuation trial results employing biomarkers. J Rheumatol. 2005 May;32(5):896-902. PubMed PMID: 15868627. https://www.ncbi.nlm.nih.gov/pubmed/15868627


Lacaille D, Anis AH, Guh DP, Esdaile JM. Gaps in care for rheumatoid arthritis: a population study. Arthritis Rheum. 2005 Apr 15;53(2):241-8. PubMed PMID: 15818655. https://www.ncbi.nlm.nih.gov/pubmed/15818655


Ad Hoc Working Group on Steroid-Sparing Criteria in Lupus (JM Esdaile, member). Criteria for steroid-sparing ability of interventions in systemic lupus erythematosus: report of a consensus meeting. Arthritis Rheum 2005;50:3427-31. https://www.ncbi.nlm.nih.gov/pubmed/15529380


American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria (JM Esdaile, member). The American College of Rheumatology response criteria for systemic lupus erythematosus clinical trials: measures of overall disease activity. Arthritis Rheum 2004;50(11):3418-3426. https://www.ncbi.nlm.nih.gov/pubmed/15529383


Hanly JG, Canadian Council of Academic Rheumatologists (JM Esdaile, member). Physician resources and postgraduate training in Canadian academic rheumatology centers: A five year prospective study. J Rheumatol 2004;31:1200-5. https://www.ncbi.nlm.nih.gov/pubmed/15170936


Bansback NJ, Regier DA, Ara R, Brennan A, Shojania K, Esdaile JM, Anis AH, Marra CA. An overview of economic evaluations for drugs used in rheumatoid arthritis : focus on tumour necrosis factor-alpha antagonists. Drugs. 2005;65(4):473-96. Review. PubMed PMID: 15733011. https://www.ncbi.nlm.nih.gov/pubmed/15733011


Marra CA, Woolcott JC, Kopec JA, Shojania K, Offer R, Brazier JE, Esdaile JM, Anis AH. A comparison of generic, indirect utility measures (the HUI2, HUI3, SF-6D, and the EQ-5D) and disease-specific instruments (the RAQoL and the HAQ) in rheumatoid arthritis. Soc Sci Med. 2005 Apr;60(7):1571-82. PubMed PMID: 15652688. https://www.ncbi.nlm.nih.gov/pubmed/15652688


Marra CA, Esdaile JM, Guh D, Kopec JA, Brazier JE, Koehler BE, Chalmers A, Anis AH. A comparison of four indirect methods of assessing utility values in rheumatoid arthritis. Med Care. 2004 Nov;42(11):1125-31. PubMed PMID: 15586840. https://www.ncbi.nlm.nih.gov/pubmed/15586840


Lacaille D, Sheps S, Spinelli JJ, Chalmers A, Esdaile JM. Identification of modifiable work-related factors that influence the risk of work disability in rheumatoid arthritis. Arthritis Rheum. 2004 Oct 15;51(5):843-52. PubMed PMID: 15478162. https://www.ncbi.nlm.nih.gov/pubmed/15478162


Cibere J, Kopec JA, Thorne A, Singer J, Canvin J, Robinson DB, Pope J, Hong P, Grant E, Esdaile JM. Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis. Arthritis Rheum. 2004 Oct 15;51(5):738-45. PubMed PMID: 15478160. https://www.ncbi.nlm.nih.gov/pubmed/15478160


Marra CA, Lynd LD, Esdaile JM, Kopec J, Anis AH. The impact of low family income on self-reported health outcomes in patients with rheumatoid arthritis within a publicly funded health-care environment. Rheumatology 2004;43:1390-7. https://www.ncbi.nlm.nih.gov/pubmed/15292531


Clarke AE, Penrod J. St. Pierre Y, Petri MA, Manzi S, Isenberg DA, Gordon C, Senecal JL, Fortin PR, Sutcliffe N, Goulet JR, Choquette D, Grodzicky T, Esdaile JM. The systemic lupus erythematosus Tri-Nation Study: Absence of a link between health resource use and health outcome. Rheumatology 2004;43:1016-24. https://www.ncbi.nlm.nih.gov/pubmed/15173602


Garbuz DS, Masri BA, Esdaile J, Duncan CP. Classification systems in orthopaedics. J Am Acad Orthop Surg. 2002 Jul-Aug;10(4):290-7. Review. PubMed  PMID: 15089078. https://www.ncbi.nlm.nih.gov/pubmed/15089078


Cibere J, Bellamy N, Thorne A, Esdaile JM, McGorm KJ, Chalmers A, Huang S, Peloso P, Shojania K, Singer J, Wong H, Kopec J. Reliability of the knee examination in osteoarthritis: effect of standardization. Arthritis Rheum. 2004 Feb;50(2):458-68. PubMed PMID: 14872488. https://www.ncbi.nlm.nih.gov/pubmed/14872488


Kopec JA, Sayre EC, Esdaile JM. Predictors of back pain in a general population cohort. Spine (Phila Pa 1976). 2004 Jan 1;29(1):70-7; discussion 77-8. PubMed PMID: 14699279. https://www.ncbi.nlm.nih.gov/pubmed/14699279


Badii M, Shin S, Torreggiani WC, Jankovic B, Gustafson P, Munk PL, Esdaile JM. Pelvic bone asymmetry in 323 study participants receiving abdominal CT scans. Spine (Phila Pa 1976). 2003 Jun 15;28(12):1335-9. PubMed PMID: 12811280. https://www.ncbi.nlm.nih.gov/pubmed/12811280


Edworthy SM, Dobkin PL, Clarke AE, Da Costa D, Dritsa M, Fortin PR, Barr S, Ensworth S, Esdaile JM, Beaulieu A, Zummer M, Senécal JL, Goulet JR, Choquette D, Rich E, Smith D, Cividino A, Gladman D, Devins GM. Group psychotherapy reduces illness intrusiveness in systemic lupus erythematosus. J Rheumatol. 2003 May;30(5):1011-6. PubMed PMID: 12734897. https://www.ncbi.nlm.nih.gov/pubmed/12734897


Al-Herz A, Ensworth S, Shojania K, Esdaile JM. Cardiovascular risk factor screening in systemic lupus erythematosus. J Rheumatol. 2003 Mar;30(3):493-6. PubMed PMID: 12610807. https://www.ncbi.nlm.nih.gov/pubmed/12610807


Cibere J, Deng Z, Lin Y, Ou R, He Y, Wang Z, Thorne A, Lehman AJ, Tsang IK, Esdaile JM. A randomized double blind, placebo controlled trial of topical Tripterygium wilfordii in rheumatoid arthritis: reanalysis using logistic regression analysis. J Rheumatol. 2003 Mar;30(3):465-7. PubMed PMID: 12610802. https://www.ncbi.nlm.nih.gov/pubmed/12610802


Marra CA, Esdaile JM, Anis AH. Practical pharmacogenetics: the cost effectiveness of screening for thiopurine s-methyltransferase polymorphisms in patients with rheumatological conditions treated with azathioprine. J Rheumatol. 2002 Dec;29(12):2507-12. PubMed PMID: 12465143. https://www.ncbi.nlm.nih.gov/pubmed/12465143


Blake VA, Allegrante JP, Robbins L, Mancuso CA, Peterson MG, Esdaile JM, Paget SA, Charlson ME. Racial differences in social network experience and perceptions of benefit of arthritis treatments among New York City Medicare beneficiaries with self-reported hip and knee pain. Arthritis Rheum. 2002 Aug;47(4):366-71. PubMed PMID: 12209481. https://www.ncbi.nlm.nih.gov/pubmed/12209481


Dobkin PL, Da Costa D, Joseph L, Fortin PR, Edworthy S, Barr S, Ensworth S, Esdaile JM, Beaulieu A, Zummer M, Senécal JL, Goulet JR, Choquette D, Rich E, Smith D, Cividino A, Gladman D, St-Pierre Y, Clarke AE. Counterbalancing patient demands with evidence: results from a pan-Canadian randomized clinical trial of brief supportive-expressive group psychotherapy for women with systemic lupus erythematosus. Ann Behav Med. 2002 Spring;24(2):88-99. PubMed PMID: 12054324. https://www.ncbi.nlm.nih.gov/pubmed/12054324


Esdaile JM. How to manage patients with lupus nephritis. Best Pract Res Clin Rheumatol. 2002 Apr;16(2):195-210. Review. PubMed PMID: 12041949. https://www.ncbi.nlm.nih.gov/pubmed/12041949


Al-Herz A, Schulzer M, Esdaile JM. Survey of antimalarial use in lupus pregnancy and lactation. J Rheumatol. 2002 Apr;29(4):700-6. PubMed PMID: 11950010. https://www.ncbi.nlm.nih.gov/pubmed/11950010


Rudicel S, Esdaile J. The randomized clinical trial in orthopaedics: obligation or option? J Bone Joint Surg Am. 1985 Oct;67-A(8):1284-93. PubMed PMID: 11650735. https://www.ncbi.nlm.nih.gov/pubmed/11650735