Hui Xie


Research Scientist, Biostatistics, BSc, MS, PhD



  • Professor, Faculty of Health Sciences, Simon Fraser University
  • Maureen and Milan Ilich / Merck Chair in Statistics for Arthritis and Musculoskeletal Diseases

Research Interests

  • Biostatistics

Dr. Hui Xie received a B.S. in Biochemistry & Moleular Biology from Peking University, a M.S. from Purdue University, and a Ph.D. in Biostatistics from Cloumbia University.

As of September 1, 2015 Dr. Xie is the Maureen and Milan Ilich / Merck Chair in Statistics for Arthritis and Musculoskeletal Diseases. He is also a Professor in the Faculty of Health Sciences at Simon Fraser University.



Tan, J.A., Choi, HK, Xie, Hui, Sayre, EC, Esdaile, JM, Avina-Zubieta, JA (2019). All-cause and Cause-specific Mortality in Granulomatosis with Polyangiitis: A Population-based Study. Arthritis Care Res. 2018 Apr 25. doi: 10.1002/acr.23587.


Li, L., Sayre, E., Xie, Hui, Falck, R., Best, J., Liu, T., Grewal, N., Hoens, A., Noonan, G. and Feehan, L. (2018) Efficacy of a Community-based Technology-enabled Physical Activity Counselling Program for People with Knee Osteoarthritis: A Proof-of-concept Study. Journal of Medical Internet Research. 20(4):e159.


Carley, DW, Prasad, B., Reid, K., Malkani, R., Attarian, H., Abbott, S., Vern, B., Xie, Hui, Yuan, C., and Zee, P. (2018). Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea. Sleep. 41(1): 1-13.


Xie, Hui, Gao, W., Xing, B., Heitjan, D., Hedeker, D., and Yuan, C. (2018) Measuring the Impact of Nonignorable Missingness Using the R Package isni. Computer Methods and Programs in Biomedicine. 164: 207-220.


Sadatsafavi, M., Xie, Hui, Etminan, M., and FitzGerald, J. M. (2018) The Association Between Previous and Future Severe Exacerbations of Chronic Obstructive Pulmonary Disease: Updating the Literature Using Robust Statistical Methodology. PLOS ONE. 13(1): 1-11.


Sanchez-Johnsen, L, Craven, M., Nava, M., Dykenma-Engblade, A., Alonso, A., Rademaker,A., and Xie, Hui (2017) Cultural Variables Underlying Obesity in Latino Men: Design, Rationale and Participant Characteristics from the Latino Men’s Health Initiative. Journal of Community Health. 42(4):826-838. 


Feferman, L., Deaton, R., Bhattacharyya, S., Xie, Hui, Gann, P., Melamed, J., Tobacman, J. (2017). Arylsulfatase B is Reduced in Prostate Cancer Recurrence. Cancer Biomarkers 21(1): 229-234.


Li, Feehan, LM, Shaw, C., Xie, Hui, Sayre, EC., Avina-Zubeita, A., Grewal, N., Townsend, A.F., Gromala, D., Noonan, G., and Backman, CL. (2017). A Technology-enabled Counselling Program versus a Delayed Treatment Control to Support Physical Activity Participation in People with Inflammatory Arthritis: Study Protocol for the OPAM-IA Randomized Controlled Trial. BMC Rheumatology. 1:6.


Li, LC, Sayre, EC, Xie, Hui, Clayton, C, and Feehan, L. (2017). A Community-based Physical Activity Couselling Program for People with Knee Osteoarthritis: Feasibility and Preliminary Effectiveness of The Track-OA Study. JMIR mhealth and uhealth. 26:5(6):e86.


Tan, J.A., Dehghan, N., Chen, W, Choi, H.K., Xie, Hui, Esdaile, J., and Avina-Zubieta, J.A. (2017). Mortality in ANCA-Associated Vasculitis: A Meta-Analysis of Observational Studies. Annals of Rheumatic Diseases. 76:1566-1574.


Xie, Hui (2017) Hybrid Monte-Carlo in Multiple Missing Data Imputations with Application to a Bone Fracture Data. In Monte-Carlo Simulation-Based Statistical Modeling edited by D.G. Chen and J.D Chen. Springer Nature Singapore.


Feferman L, Deaton R, Bhattacharyya S, Xie H, gann PH, Melamed J, Tobacman JK. Arylsulfatase B is reduced in prostate cancer recurrences. Cancer Biomarkers. 2017;21(1)229-234. https://www.ncbi.nlm.nih.gov/pubmed/29081414


Carley DW, Prasad B, Reid KJ, Malkani R, Attarian H, Abbott SM, Vern B, Xie H, Yuan C, Zee PC. Pharmacotherapy of apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in obstructive sleep apnea. Sleep. 2018 41(1)zsx184 https://www.ncbi.nlm.nih.gov/pubmed/29121334


Li LC, Sayre EC, Xie H, Clayton C, Feehan LM.  A community-based physical activity counselling program for people with knee osteoarthritis: feasibility and preliminary effectiveness of the TRACK-OA study. JMIR mHealth and uHeatlh. 2017;5(6):e86. https://www.ncbi.nlm.nih.gov/pubmed/28652228


Sanchez-Johnsen L, Craven M, Nava M, Alonso A, Dykema-Engblade A, Rademaker A, Xie H. Cultural Variables Underlying Obesity in Latino Men: Design, Rationale and Participant Characteristics from the Latino Men’s Health Initiative. J Community Health. 2017 Aug;42(4):826-838. https://www.ncbi.nlm.nih.gov/pubmed/28332066


Gao, W, Hedeker, D, Mermelstein, R and Xie, Hui (2016) A Scalable Approach to Measuring the Impact of Nonignorable Nonresponse with an EMA Application. Statistics in Medicine. 35(30):5579-5602.


Qian Y, Xie H. (2015). Drive more effective data-based innovations: enhancing the utility of secure databases. Manage Sci. 2015;61(3):520-541.


Vidovich MI, Khan AA, Xie H, Shroff AR. Radiation Safety and Vascular Access: Attitudes Among Cardiologists Worldwide. Cardiovasc Revasc Med. 2015;16(2):109-15. https://www.ncbi.nlm.nih.gov/pubmed/25669957


Guzman G, Chennuri R, Chan A, Rea B, Quintana A, Patel R, Xu PZ, Xie H, Hay N. Evidence for Heightened Hexokinase II Immunoexpression in Hepatocyte Dysplasia and Hepatocellular Carcinoma. Dig Dis Sci. 2015;60(2):420-6. https://www.ncbi.nlm.nih.gov/pubmed/25381201


Qian Y, Xie H. Which Brand Purchasers are Lost of Counterfeiters? An Application of New Data Fusion Approaches. Marketing Science.2014;33:437-448.


Xicola RM, Gagnon M, Clark JR, Carroll T, Gao W, Fernandez C, Mijic D, Rawson JB, Janoski A, Pusatcioglu CK, Rajaram P, Gluskin AB, Regan M, Chaudhry V, Abcarian H, Blumetti J, Cintron J, Melson J, Xie H, Guzman G, Emmadi R, Alagiozian-Angelova V, Kupfer SS, Braunschweig C, Ellis NA, Llor X. Excess of proximal microsatellite-stable colorectal cancer in African Americans from a multi-ethnic study. Clin Cancer Res. 2-14;20(18):4962-70. https://www.ncbi.nlm.nih.gov/pubmed/25013126


Patel H, Shivaraju A, Fonarow GC, Xie H, Gao W, Shroff AR, Vidovich MI. Temporal trends in the use of intraaortic balloon pump associated with percutaneous coronary intervention in the United States, 1998-2008. Am Heart J. Sep;168(3):363-373.e12. https://www.ncbi.nlm.nih.gov/pubmed/25173549


Shivaraju A, Yu C, Kattan MW, Xie H, Shroff AR, Vidovich M. Temporal Trends in Percutaneous Coronary Intervention Associated Acute Cerebrovascular Accident. Am Heart J. 2014;114(2):206-13. https://www.ncbi.nlm.nih.gov/pubmed/24952927


Qian, Y. and Xie, Hui* (2014) Which Brand Purchasers are Lost of Counterfeiters? An Application of New Data Fusion Approaches. Marketing Science. 33: 437-448.


Peng M, Ball-Kell SM, Franks RR, Xie H, Tyner AL. Protein Tyrosine Kinase 6 Regulates Mammary Gland Tumorigenesis in Mouse Models. Oncogenesis. 2013;(12): 2:e81. https://www.ncbi.nlm.nih.gov/pubmed/24323291


Roberts DK, Ayyagari r, McCarthy B, Xie H, Davis F, Wilensky JT. Investigating Ocular Dimensions in African-Americans with the Long Anterior Zonule. J Glaucoma. 2013;22(5): 393-7. https://www.ncbi.nlm.nih.gov/pubmed/23722729


Bosland MC, Kato I, Zeleniuch-Jacquotte A, Schmoll J, Enk Rueter E, Melamed J, Kong MX, Macias V, Kajdacsy-Balla A, Lumey LH, Xie H, Gao W, Walden P, Lepor H, Taneja SS, Randolph C, Schlicht MJ, Meserve-Watanabe H, Deaton RJ, Davies JA. (2013). Effect of Soy Protein Isolate Supplementation on Biochemical Recurrence of Prostate Cancer after Radical Prostatectomy: A Randomized Placebo-Controlled Trial. JAMA. 2013;310(2): 170-8. https://www.ncbi.nlm.nih.gov/pubmed/23839751


Epstein N, Xie H, Ruland S, et al. (2012). Vascular risk factors and cardiovascular outcomes in the Alzheimer’s Disease Neuroimaging Initiative. Am J Alzheimer’s Dis Other Demen. 2012;27(4): 275-9. https://www.ncbi.nlm.nih.gov/pubmed/22739032


Cotler SJ, Cotler S, Xie H, Luc B, Layden TJ, Wong S. Characterizing Hepatitis B Stigma in Chinese Immigrants. J Viral Hepatitis. 2012;19(2): 147-52. https://www.ncbi.nlm.nih.gov/pubmed/22239504


Gyllenhaal C, Xie H. Ethnobotanical approach vs. Random approach in the search for new bioactive compounds: Support of a hypothesis. Pharm Biol. 2012;50:30-41. https://www.ncbi.nlm.nih.gov/pubmed/22196581


Xie, Hui (2012). Analyzing longitudinal clinical trial data with nonignorable missingness and unknown missingness reasons. Computational Statistics & Data Analysis. 56:1287-1300.


Xie, Hui and Qian, Y. (2012) Measuring the impact of nonignorability in panel data with non-monotone nonresponse. Journal of Applied Econometrics, 27:129-159.