Jonathan Chan

He studied Internal Medicine at the University of British Columbia and completed his Royal College fellowship in Rheumatology. He was awarded the 2015 Assessment of Spondyloarthritis Society (ASAS) fellowship grant and completed a clinical fellowship at the University of Toronto in axial spondyloarthritis (ankylosing spondylitis). He actively pursues research in this field and has been invited to present on this topic internationally.

 

Dr. Chan is involved in the Canadian Rheumatology Association’s therapeutics committee and was coauthor of the Canadian Spondylitis Treatment Guidelines and is the core site leader of the national spondylitis and psoriatic arthritis research cohorts (SPARCC and iPART). Additionally, he is a member of the Canadian, American and international research networks (SPARCC, GRAPPA, SPARTAN and ASAS).

 

REFEREED PUBLICATIONS

1. Journals

• Rohekar S, Chan J, Tse SM, Haroon N, Chandran V, Bessette L, et al. A Brief Review of the 2014 Update on the Canadian Rheumatology Association/Spondyloarthritis Research Consortium of Canada Treatment Recommendations for the Management of Spondyloarthritis Part 1: Principles of the Management of Spondyloarthritis in Canada. J Rheumatol. 2015 Apr;42(4):654-64.

 

• Rohekar S, Chan J, Tse SM, Haroon N, Chandran V, Bessette L, et al. A Brief Review of the 2014 Update on the Canadian Rheumatology Association/Spondyloarthritis Research Consortium of Canada Treatment Recommendations for the Management of Spondyloarthritis Part 2: Specific Management Recommendations. J Rheumatol. 2015 Apr;42(4):665-81.

 

• Chan J, Sari I, Haroon N. Sacroiliitis-like Changes in Two Patients with Spina Bifida. J Rheumatol. 2016 Mar; 43(3):673.

 

• Chan J, Sari I, Salonen D, Inman RD, Haroon N. Development of a screening tool for the identification of sacroiliitis in CT scans of the abdomen. J Rheumatol. 2016; 43:9

 

• Chan J, Sari I, Salonen D, Silverberg MS, Haroon N, Inman RD. Prevalence of sacroiliitis in inflammatory bowel disease using a standardized CT scoring system. Arthritis Care Res. 2017; July 21

 

• Chan J, Gladman D. Oral treatment options for AS and PsA: DMARDs and small molecule inhibitors. Best Practice & Research Clinical Rheumatology. Approved and pending publication

 

• Kelly OB, Li, N, Smith M, Chan J, Inman RF, Silverberg MS. The Prevalence and Clinical Associations of Subclinical Sacroiliitis in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018; Nov 14

 

• Avina-Zubieta J, Chan J, De Vera M, Sayre E, Choi HK, Esdaile JM. The risk of venous thromboembolism in ankylosing spondylitis: a general population-based study. Annals of the Rheumatic Diseases 2019; 78:480-485

 

• Huang S, Chan J, Bruyere H, Allan LL, Gerrie AS, Toze CL. Chronic lymphocytic leukemia patients with HLA-B27 referred for allogenic hematopoietic stem cell transplantation do not have worse outcomes: results of a population-based series analysis in British Columbia, Canada. Leukemia Research. 2019 Jul;84:106193

 

• Megan S, Yip A, Ziouzina O, Chan J, Dutz JP. Combination Therapy with Tofacitinib and IL-12/23, IL-23, or IL-17A Inhibition for the Treatment of Refractory Psoriatic Arthritis. Journal of Clinical Rheumatology 2021 June;

 

• Choquette D, Chan J, Bardi M, Whiskin C, Torani G, Smith BK, Sihota A. Monitoring the transition of patients on biologics in rheumatoid arthritis: Consensus guidance for pharmacists. Pharm Pract (Granada). 2021Sep;19(3):2377

 

• Marinkovic A, Zypchen L.N., Chan J, Chen L.Y.C, Parkin S. Monoclonal gammopathy of clinical significance: what the rheumatologist needs to know. The Lancet Rheumatology. Accepted pending publication

 

• Darabian S, Badii M, Dutz J, Chan J. A Retrospective Study on the Effectiveness of Ixekizumab After Treatment with Secukinumab for Patients with Active Psoriatic Arthritis. Journal of Psoriasis and Psoriatic Arthritis 2021, Vol 0(0) 1-4

 

• Choquette D, Chan J, Bardi M, Whiskin C, Torani G, Smith BK, Sihota A. Monitoring the transition of patients on biologics in rheumatoid arthritis: Consensus guidance for pharmacists. Pharm Pract (Granada) 2021, Jul-Sep 14, 2021

 

• Stewart M, Lo A, Shojania K, Au S, Seidman MA, Dutz JP, Chan J. Cutaneous polyarteritis nodosa diagnosis and treatment: A retrospective case series. Journal of the American Academy of Dermatology 2022, June 14, 2022

 

• Lubrano E, Chan J, Queiro-Silva R, Cauli A, Goel N, Poddubnyy D, Nash P, Gladman DD. Management of Axial Disease in Patients With Psoriatic Arthritis: AnUpdated Literature Review Informing the 2021 GRAPPA Treatment Recommendations. J Rheumatol. Nov 1, 2022

 

• Inman RD, Garrido-Cumbrera M, Chan J, Cohen M, dr Brum-Fernandes AJ, Gerhart W, Haroon N, Jovaisas AV, Major G, Mallinson MG, Rohekar S, Leclerc P, Rahman P. Work-related Issues, Physical and Psychological Burden in Canadian Axial Spondyloarthritis Patients. Results From the International Map of Axial Spondyloarthritis. J Rheumatol. Dec 1, 2022

 

• Bessette L, Chan J, Chow A, Lisnevskaia L, Richard N, Fournier P-A, Liazoghli D, Girard T, Haaland D. Real-World Effectiveness of Upadacitinib for Treatment of Rheumatoid Arthritis in Canadian Patients: Interim Results from the Prospective Observational CLOSE-UP Study. Rheumatology and Therapy. Mar 11, 2024

 

• Gladman DD, Chandran V, Rosen CF, Rohekar S, Boyd T, Eder L, Rahman P, Dutz JP, Chan J, Haydey RP, Barac S, Laliberte MC, Girard T, Fournier PA, Sutton M, Pereira D, Chim T, Coupal L, Choquette D. Residual Disease Activity in Canadian Patients with Psoriatic Arthritis treated with Advanced Therapies: Results from a Multiregistry Analysis (UNISON-PsA). J Rheumatol. May 1, 2024

 

SUBMITTED WORK

• Sari I, Chan J, Johnson SR, Inman RD, Haroon N. Progression to Radiographic Sacroiliitis in Patients with Non-diagnostic Sacroiliac Joints: Results from a Longitudinal Observational Cohort of AxSpA Patients

 

NON-REFEREED PUBLICATIONS

• Chan J, Kur J. Update on Rheumatologist demographics in British Columbia. CRAJ 2014 Vol 24, Number 4:15.

 

ABSTRACTS

• Haaland D, Chan J, Lisnevskaia L, Chow A, Girard T, Fournier PA, Bessette L. Effectiveness of Upadacitinib in Patients with Rheumatoid Arthritis in Canadian Real-World Practice: Interim Resutls from the CLOSE-UP Post-Marketing Observational Study. Poster presentation CRA 2023

 

• Haaland D, Chan J, Lisnevskaia L, Chow A, Girard T, Fournier PA, Bessette L. Effectiveness of Upadacitinib in Patients with Rheumatoid Arthritis in Canadian Real-World Practice: Interim Resutls from the CLOSE-UP Post-Marketing Observational Study. Poster presentation ACR 2022

 

• Stewart M, Lo A, Shojania K, Au S, Seidman MA, Dutz JP, Chan, J. Cutaneous Polyarteritis Nodosa Treatment: a Retrospective Case Series. Poster presentation RDS 2021

 

• Maksymowych WP, Carmona R, Yeung J, Chan J et al. Does Imaging of the Sacroiliac Joint Differ in Patients Presenting with Undiagnosed Back Pain and Psoriasis, Acute Anterior Uveitis, and Colitis: An Inception Cohort Study. Poster presentation ACR 2021

 

• Chan J, Nicolaou S, Yan YY, Osman M, Ouellette H, Jalal S. Low Dose Dual Energy CT Scan for the Detection of Bone Marrow Edema and Erosions in Axial Spondyloarthritis. Poster presentation ACR 2021

 

• Kröber G, Weber U, Carmona R, Yeung J, Chan J, Aydin S, Martin L, Masetto A, Keeling S, Ziouzina O, Rohekar S, Dadashova R, Paschke J, Carapellucci A, Lambert RG, Maksymowych WP. Diagnostic Utility of IBP Criteria in an Inception Cohort of Patients with Psoriasis, Iritis, or Colitis Presenting with Undiagnosed Back Pain. Poster presentation 12th SpA Congress in Ghent, Belgium

 

• Weber U, Kröber G, Carmona R, Yeung J, Chan J, Aydin S, Martin L, Masetto A, Keeling S, Ziouzina O, Rohekar S, Dadashova R, Paschke J, Carapellucci A, Lambert RG, Maksymowych WP. Performance of Three Referral Algorithms for Diagnosing Axial Spondyloarthritis. Poster presentation 12th SpA Congress in Ghent, Belgium

 

• Maksymowych WP, Carmona R, Yeung J, Chan J et al. Does Imaging of the Sacroiliac Joint Differ in Patients Presenting with Undiagnosed Back Pain and Psoriasis, Acute Anterior Uveitis, and Colitis: An Inception Cohort Study. Guided Poster Tour EULAR 2021

 

• Maksymowych WP, Carmona R, Yeung J, Chan J et al. Enhanced performance of the ASAS classification criteria by deletion of non-discriminatory clinical items: data from the screening in axial spondyloarthritis in psoriasis, iritis, and colitis cohort. Poster presentation EULAR 2020

 

• Georg Krober, Ulrich Weber, Raj Carmona, James Yeung, Jon Chan, Sibel Aydin, Liam Martin, Ariel Masetto, Stephanie Keeling, Olga Ziouzina, Sherry Rohekar, Rana Dadashova, Joel Paschke, Amanda Carapellucci, Robert Lambert, Walter Maksymowych. The Relative Diagnostic Utility of Inflammatory Back Pain Criteria in an Inception Cohort of Patients with Psoriasis, Iritis, and Colitis Presenting with Undiagnosed Back Pain. Oral presentation EULAR 2020.

 

• Maksymowych WP, Carmona R, Yeung J, Chan J et al. Performance of Three Referral Algrithms for Diagnosing Axial Spondyloarthritis: Results from the Screening in Axial Spondyloarthritis for Psoriasis, Iritis, and Colitis Cohort. Poster presentation ACR 2020

 

• Georg Krober, Ulrich Weber, Raj Carmona, James Yeung, Jon Chan, Sibel Aydin, Liam Martin, Ariel Masetto, Stephanie Keeling, Olga Ziouzina, Sherry Rohekar, Rana Dadashova, Joel Paschke, Amanda Carapellucci, Robert Lambert, Walter Maksymowych. The Relative Diagnostic Utility of Inflammatory Back Pain Criteria in an Inception Cohort of Patients with Psoriasis, Iritis, and Colitis Presenting with Undiagnosed Back Pain. Oral presentation ACR 2020.

 

• Rahman P, Arendse R, Fortin I, Chow A, Khraishi M, Kapur S, Zummer M, Kherani R, Chan J et al. Effectiveness and Safety of Infliximab, Golimumab and Ustekinumab in Psoriatic Arthritis from a Prospective Observational Registry. PANLAR Ecuador 2019.

 

• Maksymowych WP, Carmona R, Yeung J, Chan J et al. What is the Impact of MRI on the Performance of the ASAS Classification Criteria in Patients Presenting with Undiagnosed Back Pain? Poster presentation EULAR Madrid 2019.

 

• Maksymowych WP, Carmona R, Yeung J, Chan J et al. Description and Prevalence of Spondyloarthritis in Unselected Patients with Psoriasis, Acute Anterior Uveitis, and Inflammatory Bowel Disease Presenting with Undiagnosed Back Pain. Poster presentation EULAR Madrid 2019.

 

• Maksymowych WP, Carmona R, Yeung J, Chan J et al. Performance of the ASAS Classification Criteria Presenting with Undiagnosed Back Pain? Data from the Screening in Axial Spondyloarthritis in Psoriasis, Iritis, and Colitis (SASPIC) Cohort. Poster presentation EULAR Madrid 2019.

 

• Maksymowych WP, Carmona R, Yeung J, Chan J et al. What Is the Impact of Imaging on Diagnostic Ascertainment of Patients Presenting with Undiagnosed Back Pain in Routine Practice and the Impact of Central Reading? Data from the Screening in Axial Spondyloarthritis in Psoriasis, Iritis, and Colitis Cohort. Oral presentation at ACR Chicago 2018. Poster presentation at EULAR Madrid 2019.

 

• What Is the Impact of Imaging on Diagnostic Ascertainment of Patients Presenting with Undiagnosed Back Pain in Routine Practice and the Impact of Central Reading? Data from the Screening in Axial Spondyloarthritis in Psoriasis, Iritis, and Colitis Cohort. Oral presentation at ACR Chicago 2018.

 

• Construct Validation of the Screening for Inflammatory Pain in the Lower Back Questionnaire: Data from the Screening in Axial Spondyloarthritis in Psoriasis, Iritis, and Colitis Cohort. Poster presentation at ACR Chicago 2018.

 

• Arendse R, Jaroszynska A, Haaland D, Boulos P, Fortin I, Kherani R, Masetto A, Chan J, Psaradellis E, Stutz M, Osborne B, Nantel F, Lehman AJ. Safety and Effectiveness of Ustekinumab for the Treatment of Psoriatic Arthritis over a 6 Month Period. Poster presentation at ACR San Diego 2017 and CRA Vancouver 2018.

 

• Maksymowych WP, Carmona R, Yeung J, Chan J et al. Diagnostic Ascertainment of Axial Spondyloarthritis in Patients Presenting with Undiagnosed Back Pain: What is the Impact of MRI in Rheumatological Practice? Poster presentation at ACR San Diego 2017 and CRA Vancouver 2018. International congress on Spondyloarthritis at Gent 2018

 

• Carmona R, Yeung J, Chan J et al. Which Criteria for Inflammatory Back Pain in Spondyloarthritis are Optimal? Data from Unselected Patients with Undiagnosed Back Pain in the Screening for Axial Spondyloarthritis Study. Poster presentation at ACR San Diego 2017, EULAR Madrid 2017, and CRA Vancouver 2018.

 

• Maksymowych WP, Carmona R, Yeung J, Chan J et al. Central Reader Assessment of Imaging in Axial Spondyloarthritis: What is the Potential Impact on the Performance of the ASAS Classification Criteria? Poster presentation at CRA Vancouver 2018.

 

• Chan J, So ACL, Sayre EC, Avina-Zubieta JA. Risk of venous thromboembolism in ankylosing spondylitis: a general population-based study. Podium presentation at ACR San Diego 2017.

 

• So ACL, Chan J, Sayre EC, Avina-Zubieta JA. Risk of myocardial infarction and cerebrovascular accident in ankylosing spondylitis: a general population-based study. Podium presentation at ACR San Diego 2017.

 

• Carmona R, Yeung J, Masetto A, Martin L, Keeling S, Chan J, Mosher D, Ziouzina O, Paschke J, Carapellucci A, Lambert R, Maksymowych WP. Which criteria for inflammatory back pain in spondyloarthritis are optimal? Data from the screening for axial spondyloarthritis in psoriasis, iritis, and colitis study (SASPIC). Poster at CRA Ottawa 2017.

 

• Sari I, Omar A, Chan J, Bedaiwi M, Ayearst R, Haroon N, Inman RD. What is the clinical utility of MR Imaging in the Management of Nr-Axspa Patients? Poster presentation at the American College of Rheumatology Meeting San Francisco, USA Nov 2015.

 

• Sari I, Chan J, Omar A, Bedaiwi M, Ayearst R, Inman RD, Haroon N. Factors Predictive of Radiographic Progression in Ankylosing Spondylitis. Poster presentation at the American College of Rheumatology Meeting San Francisco, USA Nov 2015.

 

• Omar A, Sari I, Chan J, Haroon N, Inman RD. Twitter and Rheumatology: Significant and Incremental Growth in Usage. Poster presentation at the American College of Rheumatology Meeting San Francisco, USA Nov 2015.

 

• Sari I, Chan J, Omar A, Bedaiwi M, Haroon N, Inman RD. Clinical Characteristics of Axial Spondyloarthritis Patients Progressing from Non-Diagnostic to Diagnostic Radiographic Sacroiliitis. Poster presentation at the American College of Rheumatology Meeting San Francisco, USA Nov 2015.

 

• Chan J, Sari I, Salonen D, Inman RD, Haroon N. Development of a Novel SI Joint CT score for the diagnosis of Axial Spondyloarthritis. Poster presentation at the American College of Rheumatology Meeting San Francisco, USA Nov 2015.

 

• Chan J, Sari I, Salonen D, Silverberg M, Haroon N, Inman RD. Prevalence of Sacroliitis in Inflammatory Bowel Disease Using a Standardized CT Scoring System. Guided poster tour at the American College of Rheumatology Meeting San Francisco, USA Nov 2015.

 

• Chan J, Sari I, Salonen D, Silverberg M, Inman RD, Haroon N. Abdominal X-rays can Reliably Detect the Majority of CT Positive Sacroiliitis in an IBD Cohort. Poster presentation at the American College of Rheumatology Meeting San Francisco, USA Nov 2015.

 

• Chan J, Sari I, Salonen D, Inman RD, Haroon N. Development of a Novel SI Joint CT score for the diagnosis of Axial Spondyloarthritis. Guided poster tour presented at the European League Against Rheumatism Meeting Rome, Italy June 2015.

 

• Chan J, Sari I, Salonen D, Inman RD, Haroon N. Development of a Novel SI Joint CT score for the diagnosis of Axial Spondyloarthritis. Podium presentation presented at the Ogryzlo Day Department of Rheumatology Research Day, University of Toronto June 2015.

 

• Chan J, Sari I, Salonen D, Silverberg M, Haroon N, Inman RD. Prevalence of Sacroliitis in Inflammatory Bowel Disease Using a Standardized CT Scoring System. Guided poster tour presented at the Ogryzlo Day Department of Rheumatology Research Day, University of Toronto June 2015.

 

• Chan J, Sari I, Salonen D, Silverberg M, Inman RD, Haroon N. Abdominal X-rays can Reliably Detect the Majority of CT Positive Sacroiliitis in an IBD Cohort. Guided poster tour presented at the Ogryzlo Day Department of Rheumatology Research Day, University of Toronto June 2015.

 

• Chan J, Sari I, Salonen D, Inman RD, Haroon N. Development of a Novel SI Joint CT score for the diagnosis of Axial Spondyloarthritis. Guided poster tour presented at the Ontario Rheumatology Association Annual meeting May 2015.

 

• Sari I, Chan J, Omar A, Bedawi M, Ayearst R, Inman RD, Haroon N. Clinical factors at baseline predictive of subsequent radiographic progression in ankylosing spondylitis. Guided poster tour presented at the Ogryzlo Day Department of Rheumatology Research Day, University of Toronto June 2015.

 

• Sari I, Omar A, Chan J, Bedawi M, Ayearst R, Haroon N, Inman RD. What is the clinical utility of MR imaging in the management of nr-axSpA patients? Guided poster tour presented at the Ogryzlo Day Department of Rheumatology Research Day, University of Toronto June 2015.

 

BOOKS

1. Authored
2. Edited
3. Chapters

• Chan J, Haroon N. NSAID Therapy in Axial Spondyloarthritis. In Axial Spondyloarthritis. Inman RD, Sieper J (ed). Oxford University Press.

 

OTHER WORK

• International Psoriasis and Arthritis Research Team (iPART): Susceptibility Factors for Arthritis in Subjects with Psoriasis

a. The purpose of the study is to identify differences between genetic makeup of psoriasis patients with and without  arthritis as well as to develop a web-based database of psoriasis patients for future genetic studies. My role is to assess patients with psoriasis for extent of skin and joint disease using the iPART physician protocol. DNA samples are taken from each patient and assessments are made on an annual basis.

b. Local principal investigators: Dr. Jan Dutz and Dr. Jonathan Chan