A study of the risk of blood clots in patients with Granulomatosis with Polyangiitis



Study Title: Increased Risk of Venous Thromboembolism in Patients with Granulomatosis with Polyangiitis: A Population-Based Study

Principal Investigator: 
Antonio Aviña-Zubieta MD, MSc, PhD, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine, University of British Columbia

Study Start Date:
2016  |  End Date: 2017


What were the key findings?


Patients with granulomatosis with polyangiitis (GPA, formerly known as Wegener’s disease) have a much higher risk of blood clots in the lungs and legs.  For GPA patients, it is recommended more attention should be given to monitor for these complications, especially early after diagnosis.


What was done?


Using a population-based database that includes all people living in British Columbia, we looked at the rate of venous thromboembolism (blood clots) in patients diagnosed with GPA compared to the general population (people who did not have GPA).


Who was involved?



Alice Mai MD
Resident Physician, Division of Rheumatology, Faculty of Medicine, University of British Columbia

Neda Amiri, MD
Resident Physician, Faculty of Medicine, University of British Columbia

Ju Ann Tan, MSc candidate
Arthritis Research Canada

Hyon Choi, MD, DrPH
Professor of Medicine, Harvard Medical School
Director of Clinical Epidemiology in the Division of Rheumatology, Allergy, and Immunology at Massachusetts General Hospital

Research Staff:

Lynn Nowoselski, MPH
Research Assistant, Arthritis Research Canada

Eric C Sayre, PhD
Statistician, Arthritis Research Canada


Who is funding the research?


This study was funded by the Canadian Arthritis Network, The Arthritis Society of Canada/the British Columbia Lupus Society, and The Canadian Institutes of Health Research.