Jolanda Cibere

Senior Scientist of Rheumatology, MD, FRCPC, PhD

 

Appointments

  • Associate Professor, Division of Rheumatology, Department of Medicine, University of British Columbia

Research Interests

  • Osteoarthritis

Dr. Jolanda Cibere is a rheumatologist specializing in the research of osteoarthritis, a degenerative disease that is affecting an increasing number of Canadians.

After completing her medical and internal medicine training at the University of Saskatchewan, Dr. Cibere completed her clinical rheumatology training at the University of British Columbia. She also trained in the University of British Columbia ‘s Department of Health Care and Epidemiology, completed a doctoral program focusing on osteoarthritis, and was awarded an MRC (now CIHR) Clinician Scientist Fellowship award for her studies.

Learn more

Dr. Cibere pioneered a study on the current use of glucosamine sulfate by osteoarthritis sufferers, the results of which have been widely disseminated to consumers across North America. The 24-week study involving 137 subjects in four Canadian centres, all of who were using glucosamine at the start of the study, found no evidence of benefit from continued use of glucosamine.

Dr. Cibere was the principal investigator for a research study on the early diagnosis of osteoarthritis. Her research led to the development of a standardized knee exam that has since become part of a clinical standard for early detection. She has reported that early knee osteoarthritis can be detected by findings of either joint swelling, gait abnormality or flexion contracture in the knee. She worked with the late Leslie Nielsen to produce a video to help disseminate these results to family practitioners and health care professionals. In addition, her study found that specific blood and urine tests, which detect cartilage breakdown, are useful to identify early osteoarthritis of the knee. She is the principal investigator for ongoing research to investigate the progression of osteoarthritis of the knee after 3 and 6 years, and is involved with similar research on osteoarthritis of the hip.

Dr. Cibere received the Networks of Centres of Excellence Young Innovator Award early in her career. She was awarded a six-year Clinical Scientist Phase II Scholar Award (the highest level salary award given by the Canadian Institutes of Health Research), and received both the UBC’s Departmental Faculty Scholar Award and the J. W. McConnell Family Foundation Scholar.

Publications

Cibere J, Guermazi A, Nicolaou S, Esdaile JM, Thorne A, Singer J, Wong H, Kopec JA, Sayre EC. Association of physical examination knee effusion with bone marrow lesions: cross-sectional and longitudinal analyses of a population-based cohort. Arthritis Care & Research. Accepted. https://www.ncbi.nlm.nih.gov/pubmed/29648685

 

Keng A‡, Sayre EC, Guermazi A, Nicolaou S, Esdaile JM, Thorne A, Singer J, Kopek JA, Cibere J. Association of body mass index with knee cartilage damage in an asymptomatic population-based study. BMC Musculoskelet Disord. 2017 Dec 8;18(1):517. (‡J. Cibere, Summer Medical Student supervisor). (SA). https://www.ncbi.nlm.nih.gov/pubmed/29221481

 

Guo YZ‡, Zhang H, Qian H, Wilson D, Wong H, Barber M, Forster B, Esdaile J, Cibere J. The association of femoroacetabular impingement and delayed gadolinium enhanced MRI of cartilage (DGEMRIC): a population-based study. Arthritis Care Res. 2017 Nov doi: 10.1002/acr.23463. [Epub ahead of print]. (‡ J. Cibere, Summer Medical Student supervisor). https://www.ncbi.nlm.nih.gov/pubmed/29112800

 

Sayre EC, Guermazi A, Esdaile JM, Kopec JA, Singer J, Thorne A, Nicolaou S, Cibere J. Associations between MRI features versus knee pain severity and progression: Data from the Vancouver Longitudinal Study of Early Knee Osteoarthritis. PLoS One. 2017 May 4;12(5):e0176833. doi: 10.1371/journal.pone.0176833. eCollection 2017. PubMed PMID: 28472071; PubMed Central PMCID: PMC5417516. https://www.ncbi.nlm.nih.gov/pubmed/28472071

 

Kopec JA, Cibere J, Li LC, Zhang C, Barber M, Qian H, Wong H, Steininger G, Prlic H, Simatovic J, Ratzlaff C, Sayre EC, Ye J, Forster BB, Esdaile JM; IMPAKT-HIP Study Team. Relationship between physical activity and hip pain in persons with and without cam or pincer morphology: a population-based case-control study. Osteoarthritis Cartilage. 2017 Feb 20. pii: S1063-4584(17)30862-2. https://www.ncbi.nlm.nih.gov/pubmed/28219714

 

Rahman MM, Kopec JA, Goldsmith CH, Anis AH, Cibere J. Validation of Administrative Osteoarthritis Diagnosis Using a Clinical and Radiological Population-Based Cohort. Int J Rheumatol. 2016;2016:6475318. doi: 10.1155/2016/6475318. Epub 2016 Dec 29. PubMed PMID: 28127309; PubMed Central PMCID: PMC5227164. https://www.ncbi.nlm.nih.gov/pubmed/28127309

 

Poole AR, Ha N, Bourdon S, Sayre EC, Guermazi A, Cibere J. Ability of a Urine Assay of Type II Collagen Cleavage by Collagenases to Detect Early Onset and Progression of Articular Cartilage Degeneration: Results from a Population-based Cohort Study. J Rheumatol. 2016 Oct;43(10):1864-1870. Epub 2016 Aug 1. PubMed PMID: 27481905. https://www.ncbi.nlm.nih.gov/pubmed/27481905

 

Guo Y, Kopec JA, Cibere J, Li LC, Goldsmith CH. Population Survey Features and Response Rates: A Randomized Experiment. Am J Public Health. 2016 Aug;106(8):1422-6. doi: 10.2105/AJPH.2016.303198. Epub 2016 May 19. PubMed PMID: 27196650. https://www.ncbi.nlm.nih.gov/pubmed/27196650

 

Ratzlaff C, Zhang C, Korzan J, Josey L, Wong H, Cibere J, Prlic H, Kopec JA, Esdaile JM, Li LC, Barber M, Gilbart M, Forster BB. The validity of a Non-Radiologist to Identify Femoroacetabular Impingement Using Plain Radiography. Rheumatol Int 2016;36(3):371-6. https://www.ncbi.nlm.nih.gov/pubmed/26433895

 

Zhang C, Li L, Forster BB, Kopec JA, Ratzlaff C, Halai L, Cibere J, Esdaile JM. Femoroacetabular impingement and osteoarthritis of the hip. Can Fam Physician. 2015 Dec;61(12):1055-60. PubMed PMID: 26668284; PubMed Central PMCID: PMC4677941. https://www.ncbi.nlm.nih.gov/pubmed/26668284

 

Hung A, Sayre EC, Guermazi A, Esdaile JM, Kopec JA, Thorne A, Singer J, Wong H, Nicolaou S, Cibere J. Association of Body Mass Index With Incidence and Progression of Knee Effusion on Magnetic Resonance Imaging and on Knee Examination. Arthritis Care Res (Hoboken). 2016 Apr;68(4):511-6. doi: 10.1002/acr.22714. PubMed PMID: 26359653. https://www.ncbi.nlm.nih.gov/pubmed/26359653

 

Rahman MM, Cibere J, Anis AH, Goldsmith CH, Kopec JA. Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study. Int J Rheumatol. 2014;2014:620920. doi: 10.1155/2014/620920. Epub 2014 Nov 4. PubMed PMID: 25538769; PubMed Central PMCID: PMC4236891. https://www.ncbi.nlm.nih.gov/pubmed/25538769

 

Rahman MM, Cibere J, Goldsmith CH, Anis AH, Kopec JA. Osteoarthritis incidence and trends in administrative health records from British Columbia, Canada. J Rheumatol. 2014 Jun;41(6):1147-54. doi: 10.3899/jrheum.131011. Epub 2014 Apr 15. PubMed PMID: 24737915. https://www.ncbi.nlm.nih.gov/pubmed/24737915

 

Crema MD, Cibere J, Sayre EC, Roemer FW, Wong H, Thorne A, Singer J, Esdaile JM, Marra MD, Kopec JA, Nicolaou S, Guermazi A. The relationship between subchondral sclerosis detected with MRI and cartilage loss in a cohort of subjects with knee pain: the Knee Osteoarthritis Progression (KOAP) study. Osteoarthritis Cartilage 2014;22:540-6. https://www.ncbi.nlm.nih.gov/pubmed/24508776

 

Marra CA, Grubisic M, Cibere J, Grindrod KA, Woolcott JC, Gastonguay L, Esdaile JM. Cost-utility analysis of a multidisciplinary strategy to manage osteoarthritis of the knee: economic evaluation of a cluster randomized controlled trial study. Arthritis Care Res (Hoboken). 2014 Jun;66(6):810-6. doi: 10.1002/acr.22232. PubMed PMID: 24249680. https://www.ncbi.nlm.nih.gov/pubmed/24249680

 

Jaremko JL, Lambert RG, Zubler V, Weber U, Loeuille D, Roemer FW, Cibere J, Pianta M, Gracey D, Conaghan P, Ostergaard M, Maksymowych WP. Methodologies for semiquantitative evaluation of hip osteoarthritis by magnetic resonance imaging: approaches based on the whole organ and focused on active lesions. J Rheumatol.2014 Feb;41(2):359-69. doi: 10.3899/jrheum.131082. Epub 2013 Nov 15. Review. PubMed PMID: 24241486. https://www.ncbi.nlm.nih.gov/pubmed/24241486

 

Maksymowych WP, Cibere J, Loeuille D, Weber U, Zubler V, Roemer FW, Jaremko JL, Sayre EC, Lambert RG. Preliminary validation of 2 magnetic resonance image scoring systems for osteoarthritis of the hip according to the OMERACT filter. J Rheumatol. 2014 Feb;41(2):370-8. doi: 10.3899/jrheum.131083. Epub 2013 Nov 15. PubMed PMID: 24241483. https://www.ncbi.nlm.nih.gov/pubmed/24241483

 

Davis EM, Lynd LD, Grubisic M, Kopec JA, Sayre EC, Cibere J, Esdaile J, Marra CA. Responsiveness of health state utility values in knee osteoarthritis. J Rheumatol. 2013 Dec;40(12):2075-82. doi: 10.3899/jrheum.130176. Epub 2013 Nov 1. PubMed PMID: 24187098. https://www.ncbi.nlm.nih.gov/pubmed/24187098

 

Sayre EC, Singer J, Thorne A, Wong H, Kopec JA, Esdaile JM, Guermazi A, Nicolaou S, Cibere J. Does moderate or severe nonspecific knee injury affect radiographic osteoarthritis incidence and progression? BMC Musculoskelet Disord. 2013 Oct 28;14:309. doi: 10.1186/1471-2474-14-309. PubMed PMID: 24164716; PubMed Central PMCID: PMC4231427. https://www.ncbi.nlm.nih.gov/pubmed/24164716

 

Rahman MM, Kopec JA, Anis AH, Cibere J, Goldsmith CH. Risk of cardiovascular disease in patients with osteoarthritis: a prospective longitudinal study. Arthritis Care Res (Hoboken). 2013 Dec;65(12):1951-8. doi: 10.1002/acr.22092. PubMed PMID: 23925995. https://www.ncbi.nlm.nih.gov/pubmed/23925995

 

Rahman MM, Kopec JA, Cibere J, Goldsmith CH, Anis AH. The relationship between osteoarthritis and cardiovascular disease in a population health survey: a cross-sectional study. BMJ Open. 2013 May 14;3(5). pii: e002624. doi: 10.1136/bmjopen-2013-002624. PubMed PMID: 23674445; PubMed Central PMCID: PMC3657665. https://www.ncbi.nlm.nih.gov/pubmed/23674445

 

Li LC, Lineker S, Cibere J, Crooks VA, Jones CA, Kopec JA, Lear SA, Pencharz J, Rhodes RE, Esdaile JM. Capitalizing on the teachable moment: osteoarthritis physical activity and exercise net for improving physical activity in early knee osteoarthritis. JMIR Res Protoc. 2013 May 9;2(1):e17. doi: 10.2196/resprot.2553. PubMed PMID: 23659903; PubMed Central PMCID: PMC3650932.  https://www.ncbi.nlm.nih.gov/pubmed/23659903

 

Ratzlaff C, Simatovic J, Wong H, Li L, Ezzat A, Langford D, Esdaile JM, Kennedy C, Embley P, Caves D, Hopkins T, Cibere J. Reliability of hip examination tests for femoroacetabular impingement. Arthritis Care Res (Hoboken). 2013 Oct;65(10):1690-6. doi: 10.1002/acr.22036. PubMed PMID: 23609994. https://www.ncbi.nlm.nih.gov/pubmed/23609994

 

Ezzat AM, Cibere J, Koehoorn M, Li LC. Association between cumulative joint loading from occupational activities and knee osteoarthritis. Arthritis Care Res (Hoboken). 2013 Oct;65(10):1634-42. doi: 10.1002/acr.22033. PubMed PMID: 23609965. https://www.ncbi.nlm.nih.gov/pubmed/23609965

 

Hunt MA, Pollock CL, Kraus VB, Saxne T, Peters S, Huebner JL, Sayre EC, Cibere J. Relationships amongst osteoarthritis biomarkers, dynamic knee joint load, and exercise: results from a randomized controlled pilot study. BMC Musculoskelet Disord. 2013 Mar 27;14:115. doi: 10.1186/1471-2474-14-115. PubMed PMID: 23530976; PubMed Central PMCID: PMC3623736. https://www.ncbi.nlm.nih.gov/pubmed/23530976

 

Kopec JA, Sayre EC, Schwartz TA, Renner JB, Helmick CG, Badley EM, Cibere J, Callahan LF, Jordan JM. Occurrence of radiographic osteoarthritis of the knee and hip among African Americans and whites: a population-based prospective cohort study. Arthritis Care Res (Hoboken). 2013 Jun;65(6):928-35. doi: 10.1002/acr.21924. PubMed PMID: 23281251; PubMed Central PMCID: PMC4206562. https://www.ncbi.nlm.nih.gov/pubmed/23281251

 

Marra CA, Cibere J, Grubisic M, Grindrod KA, Gastonguay L, Thomas JM, Embley P, Colley L, Tsuyuki RT, Khan KM, Esdaile JM. Pharmacist-initiated intervention trial in osteoarthritis: a multidisciplinary intervention for knee osteoarthritis. Arthritis Care Res (Hoboken). 2012 Dec;64(12):1837-45. doi: 10.1002/acr.21763. PubMed PMID: 22930542. https://www.ncbi.nlm.nih.gov/pubmed/22930542

 

Ratzlaff C, Koehoorn M, Cibere J, Kopec J. Clinical validation of an internet-based questionnaire for ascertaining hip and knee osteoarthritis. Osteoarthritis Cartilage 2012;20(12):1568-73. https://www.ncbi.nlm.nih.gov/pubmed/22975023

 

Ratzlaff CR, Koehoorn M, Cibere J, Kopec JA. Is lifelong knee joint force from work, home, and sport related to knee osteoarthritis? Int J Rheumatol. 2012;2012:584193. doi: 10.1155/2012/584193. Epub 2012 Jul 17. PubMed PMID: 22848225; PubMed Central PMCID: PMC3405641. https://www.ncbi.nlm.nih.gov/pubmed/22848225

 

Li LC, Sayre EC, Kopec JA, Esdaile JM, Bar S, Cibere J. Quality of nonpharmacological care in the community for people with knee and hip osteoarthritis. J Rheumatol. 2011 Oct;38(10):2230-7. doi: 10.3899/jrheum.110264. Epub 2011 Aug 1. PubMed PMID: 21807776. https://www.ncbi.nlm.nih.gov/pubmed/21807776

 

Crema MD, Guermazi A, Sayre EC, Roemer FW, Wong H, Thorne A, Singer J, Esdaile JM, Marra MD, Kopec JA, Nicolaou S, Cibere J. The association of magnetic resonance imaging (MRI)-detected structural pathology of the knee with crepitus in a population-based cohort with knee pain: the MoDEKO study. Osteoarthritis Cartilage 2011;19(12):1429-32. https://www.ncbi.nlm.nih.gov/pubmed/21945851

 

Roemer FW, Hunter DJ, Winterstein A, Li L, Kim YJ, Cibere J, Mamisch TC, Bohndorf K, Guermazi A. Hip Osteoarthritis MRI Scoring System (HOAMS): Reliability and associations with radiographic and clinical findings. Osteoarthritis Cartilage 2011;19(8):946-62. https://www.ncbi.nlm.nih.gov/pubmed/21550411

 

Cibere J, Sayre EC, Guermazi A, Nicolaou S, Kopec JA, Esdaile JM, Thorne A, Singer J, Wong H. Natural history of cartilage damage and osteoarthritis progression on magnetic resonance imaging in a population-based cohort with knee pain. Osteoarthritis Cartilage 2011;19(6):683-8. https://www.ncbi.nlm.nih.gov/pubmed/21329760

 

Ip S, Sayre EC, Guermazi A, Nicolaou S, Wong H, Thorne A, Singer J, Kopec JA, Esdaile JM, Cibere J. Frequency of bone marrow lesions and association with pain severity: results from a population-based symptomatic knee cohort. J Rheumatol. 2011 Jun;38(6):1079-85. doi: 10.3899/jrheum.100587. Epub 2011 Mar 1. PubMed PMID: 21362771. https://www.ncbi.nlm.nih.gov/pubmed/21362771

 

Ratzlaff C, Steininger G, Doerfling P, Koehoorn M, Cibere J, Liang M, Wilson D, Esdaile J, Kopec J. Influence of lifetime hip joint force on the risk of self-reported hip osteoarthritis: A community-based cohort study. Osteoarthritis Cartilage 2011;19:389-98. https://www.ncbi.nlm.nih.gov/pubmed/21255666

 

Rahman MM, Kopec JA, Sayre EC, Greidanus NV, Aghajanian J, Anis AH, Cibere J, Jordan JM, Badley EM. Effect of sociodemographic factors on surgical consultations and hip or knee replacements among patients with osteoarthritis in British Columbia, Canada. J Rheumatol. 2011 Mar;38(3):503-9. doi: 10.3899/jrheum.100456. Epub 2010 Nov 15. PubMed PMID: 21078721. https://www.ncbi.nlm.nih.gov/pubmed/21078721

 

Cibere J, Zhang H, Thorne A, Wong H, Singer J, Kopec JA, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Association of clinical findings with pre-radiographic and radiographic knee osteoarthritis in a population-based study. Arthritis Care Res (Hoboken). 2010 Dec;62(12):1691-8. doi: 10.1002/acr.20314. Epub 2010 Jul 27. PubMed PMID: 20665737. https://www.ncbi.nlm.nih.gov/pubmed/20665737

 

Ratzlaff CR, Doerfling P, Steininger G, Koehoorn M, Cibere J, Liang M, Wilson DR, Esdaile J, Kopec J. Lifetime trajectory of physical activity according to energy expenditure and joint force. Arthritis Care Res (Hoboken). 2010 Oct;62(10):1452-9. doi: 10.1002/acr.20243. PubMed PMID: 20506184. https://www.ncbi.nlm.nih.gov/pubmed/20506184

 

Sayre EC, Li LC, Kopec JA, Esdaile JM, Bar S, Cibere J. The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis. PLoS One. 2010 May 3;5(5):e10470. doi: 10.1371/journal.pone.0010470. PubMed PMID: 20454665; PubMed Central PMCID: PMC2862713. https://www.ncbi.nlm.nih.gov/pubmed/20454665

 

Sayre EC, Jordan JM, Cibere J, Murphy L, Schwartz TA, Helmick CG, Renner JB, Rahman MM, Aghajanian J, Kang W, Badley EM, Kopec JA. Quantifying the association of radiographic osteoarthritis in knee or hip joints with other knees or hips: the Johnston County Osteoarthritis Project. J Rheumatol. 2010 Jun;37(6):1260-5. doi: 10.3899/jrheum.091154. Epub 2010 Apr 15. PubMed PMID: 20395646. https://www.ncbi.nlm.nih.gov/pubmed/20395646

 

Kopec JA, Sayre EC, Flanagan WM, Fines P, Cibere J, Rahman M, Bansback NJ, Anis AH, Jordan JM, Sobolev B, Aghajanian J, Kang W, Greidanus NV, Garbuz DS, Hawker GA, Badley EM. Development of a population-based microsimulation model of osteoarthritis in Canada. Osteoarthritis Cartilage 2010;18:303-11 https://www.ncbi.nlm.nih.gov/pubmed/19879999

 

McWalter E, Wilson D, Cibere J, MacIntyre N. A single measure of patellar kinematics is an inadequate surrogate marker for patterns of three-dimensional kinematics in healthy knees. Knee 2010;17:135-40. https://www.ncbi.nlm.nih.gov/pubmed/19720534