Jacek Kopec

Senior Scientist of Epidemiology, MD, MSc, PhD

 

Appointments

  • Professor, School of Population and Public Health, University of British Columbia

Research Interests

  • Musculoskeletal epidemiology
  • Quality of life measurement
  • Population health

 

Dr. Jacek Kopec is a professor in the School of Population and Public Health at the University of British Columbia (UBC). He is also a Senior Scientist at Arthritis Research Canada and is affiliated with the UBC Department of Medicine, the Centre for Hip Health and Mobility, the Institute for Work and Health in Toronto, and the National Surgical Adjuvant Breast and Bowel Project in the USA.

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Dr. Kopec earned his MD degree from the Pomeranian Medical University in Poland and his PhD from the Department of Epidemiology and Biostatistics, McGill University. His scholastic achievements have been recognized with the National Health Research Scholar Award from Health Canada and the Senior Scholar Award from the Michael Smith Foundation for Health Research.

Dr. Kopec’s research interests include musculoskeletal epidemiology, quality of life measurement, and population health. He is an international authority on disability and quality of life assessments, and his survey on disability levels among back pain sufferers is used by researchers worldwide. Dr. Kopec has taught courses in epidemiology, measurement methods and survey design, and has supervised or co-supervised 30 graduate students.

Publications

Szkup M, Jurczak A, Karakiewicz B, Kotwas A, Kopeć J, Grochans E. Influence of cigarette smoking on hormone and lipid metabolism in women in late reproductive stage. Clin Interv Aging. 2018 Jan 17;13:109-115. https://www.ncbi.nlm.nih.gov/pubmed/29398911

 

Keng A, Sayre EC, Guermazi A, Nicolaou S, Esdaile JM, Thorne A, Singer J, Kopec JA, Cibere J. Association of body mass index with knee cartilage damage in an asymptomatic population-based study. BMC Musculoskelet Disord. 2017 Dec 8;18(1):517. https://www.ncbi.nlm.nih.gov/pubmed/29221481

 

GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1345-1422. https://www.ncbi.nlm.nih.gov/pubmed/28919119

 

GBD 2015 Healthcare Access and Quality Collaborators. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015. Lancet. 2017 May 18. pii: S0140-6736(17)30818-8. https://www.ncbi.nlm.nih.gov/pubmed/28528753

 

GBD 2016 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1260-1344. https://www.ncbi.nlm.nih.gov/pubmed/28919118

 

GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1211-1259. https://www.ncbi.nlm.nih.gov/pubmed/28919117 

 

GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1151-1210. https://www.ncbi.nlm.nih.gov/pubmed/28919116 

 

GBD 2016 Mortality Collaborators. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1084-1150. https://www.ncbi.nlm.nih.gov/pubmed/28919115

 

GBD 2016 SDG Collaborators. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1423-1459. https://www.ncbi.nlm.nih.gov/pubmed/28916366

 

Sawatzky R, Russell LB, Sajobi TT, Lix LM, Kopec J, Zumbo BD. The use of latent variable mixture models to identify invariant items in test construction. Qual Life Res. 2017 Aug 23. doi: 10.1007/s11136-017-1680-8. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/28836090

 

GBD 2015 Eastern Mediterranean Region Adolescent Health Collaborators, Mokdad AH. Adolescent health in the Eastern Mediterranean Region: findings from the global burden of disease 2015 study. Int J Public Health. 2017 Aug 3. doi: 10.1007/s00038-017-1003-4. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/28776253

 

GBD 2015 Eastern Mediterranean Region Intentional Injuries Collaborators, Mokdad AH. Intentional injuries in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study. Int J Public Health. 2017 Aug 3. doi: 10.1007/s00038-017-1005-2. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/28776251

 

GBD 2015 Eastern Mediterranean Region Diarrhea Collaborators, Mokdad AH. Burden of diarrhea in the Eastern Mediterranean Region, 1990-2015: Findings from the Global Burden of Disease 2015 study. Int J Public Health. 2017 Aug 3. doi: 10.1007/s00038-017-1008-z. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/28776239

 

GBD 2015 Eastern Mediterranean Region Collaborators, Mokdad AH. Danger ahead: the burden of diseases, injuries, and risk factors in the Eastern Mediterranean Region, 1990-2015. Int J Public Health. 2017 Aug 3. doi: 10.1007/s00038-017-1017-y. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/28776238

 

GBD 2015 Healthcare Access and Quality Collaborators. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015. Lancet. 2017 Jul 15;390(10091):231-266. https://www.ncbi.nlm.nih.gov/pubmed/28528753

 

GBD 2015 Tobacco Collaborators. Smoking prevalence and attributable disease burden in 195 countries and territories, 1990-2015: a systematic analysis from the Global Burden of Disease Study 2015. Lancet. 2017 May 13;389(10082):1885-1906. https://www.ncbi.nlm.nih.gov/pubmed/28390697

 

Sayre EC, Guermazi A, Esdaile JM, Kopec JA, Singer J, Thorne A, Nicolaou S, Cibere J. Associations between MRI features versus knee pain severity and progression: Data from the Vancouver Longitudinal Study of Early Knee Osteoarthritis. PLoS One. 2017 May 4;12(5):e0176833. doi: 10.1371/journal.pone.0176833. eCollection 2017. PubMed PMID: 28472071; PubMed Central PMCID: PMC5417516. https://www.ncbi.nlm.nih.gov/pubmed/28472071

 

Kopec JA, Cibere J, Li LC, Zhang C, Barber M, Qian H, Wong H, Steininger G, Prlic H, Simatovic J, Ratzlaff C, Sayre EC, Ye J, Forster BB, Esdaile JM; IMPAKT-HIP Study Team. Relationship between physical activity and hip pain in persons with and without cam or pincer morphology: a population-based case-control study. Osteoarthritis Cartilage. 2017 Feb 20. pii: S1063-4584(17)30862-2. https://www.ncbi.nlm.nih.gov/pubmed/28219714

 

Moradi-Lakeh M, Forouzanfar MH, Vollset SE, El Bcheraoui C, Daoud F, Afshin A, Charara R, Khalil I, Higashi H, Abd El Razek MM, Kiadaliri AA, Alam K, Akseer N, Al-Hamad N, Ali R, AlMazroa MA, Alomari MA, Al-Rabeeah AA, Alsharif U, Altirkawi KA, Atique S, Badawi A, Barrero LH, Basulaiman M, Bazargan-Hejazi S, Bedi N, Bensenor IM, Buchbinder R, Danawi H, Dharmaratne SD, Zannad F, Farvid MS, Fereshtehnejad SM, Farzadfar F, Fischer F, Gupta R, Hamadeh RR, Hamidi S, Horino M, Hoy DG, Hsairi M, Husseini A, Javanbakht M, Jonas JB, Kasaeian A, Khan EA, Khubchandani J, Knudsen AK, Kopec JA, Lunevicius R, Abd El Razek HM, Majeed A, Malekzadeh R, Mate K, Mehari A, Meltzer M, Memish ZA, Mirarefin M, Mohammed S, Naheed A, Obermeyer CM, Oh IH, Park EK, Peprah EK, Pourmalek F, Qorbani M, Rafay A, Rahimi-Movaghar V, Shiri R, Rahman SU, Rai RK, Rana SM, Sepanlou SG, Shaikh MA, Shiue I, Sibai AM, Silva DA, Singh JA, Skogen JC, Terkawi AS, Ukwaja KN, Westerman R, Yonemoto N, Yoon SJ, Younis MZ, Zaidi Z, Zaki ME, Lim SS, Wang H, Vos T, Naghavi M, Lopez AD, Murray CJ, Mokdad AH. Burden of musculoskeletal disorders in the Eastern Mediterranean Region, 1990-2013: findings from the Global Burden of Disease Study 2013. Ann Rheum Dis. 2017 Feb 16. pii: annrheumdis-2016-210146. doi: 10.1136/annrheumdis-2016-210146. [Epub ahead of print] PubMed PMID: 28209629. https://www.ncbi.nlm.nih.gov/pubmed/28209629

 

Rahman MM, Kopec JA, Goldsmith CH, Anis AH, Cibere J. Validation of Administrative Osteoarthritis Diagnosis Using a Clinical and Radiological Population-Based Cohort. Int J Rheumatol. 2016;2016:6475318. doi: 10.1155/2016/6475318. Epub 2016 Dec 29. PubMed PMID: 28127309; PubMed Central PMCID: PMC5227164. https://www.ncbi.nlm.nih.gov/pubmed/28127309

 

GBD 2015 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1659-1724. https://www.ncbi.nlm.nih.gov/pubmed/27733284

 

GBD 2015 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1603-1658. https://www.ncbi.nlm.nih.gov/pubmed/27733283

 

GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1545-1602. https://www.ncbi.nlm.nih.gov/pubmed/27733282

 

GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1459-1544. https://www.ncbi.nlm.nih.gov/pubmed/27733281

 

Guo Y, Kopec JA, Cibere J, Li LC, Goldsmith CH. Population Survey Features and Response Rates: A Randomized Experiment. Am J Public Health. 2016 Aug;106(8):1422-6. doi: 10.2105/AJPH.2016.303198. Epub 2016 May 19. PubMed PMID: 27196650. https://www.ncbi.nlm.nih.gov/pubmed/27196650

 

Sharif B, Kopec JA, Wong H, Anis AH. Distribution and Drivers of Average Direct Cost of Osteoarthritis in Canada From 2003 to 2010. Arthritis Care Res (Hoboken). 2017 Feb;69(2):243-251. doi: 10.1002/acr.22933. PubMed PMID: 27159532. https://www.ncbi.nlm.nih.gov/pubmed/27159532

 

Sawatzky R, Ratner PA, Kopec JA, Wu AD, Zumbo BD. The Accuracy of Computerized Adaptive Testing in Heterogeneous Populations: A Mixture Item-Response Theory Analysis. PLoS One. 2016 Mar 1;11(3):e0150563. doi: 10.1371/journal.pone.0150563. eCollection 2016. PubMed PMID: 26930348; PubMed Central PMCID: PMC4773251. https://www.ncbi.nlm.nih.gov/pubmed/26930348

 

Zhang C, Li L, Forster BB, Kopec JA, Ratzlaff C, Halai L, Cibere J, Esdaile JM. Femoroacetabular impingement and osteoarthritis of the hip. Can Fam Physician. 2015 Dec;61(12):1055-60. PubMed PMID: 26668284; PubMed Central PMCID: PMC4677941. https://www.ncbi.nlm.nih.gov/pubmed/26668284

 

Kopec JA, Sayre EC, Fines P, Flanagan WM, Nadeau C, Okhmatovskaia A, Wolfson MC; Simulation Technology for Applied Research Team. Effects of Reductions in Body Mass Index on the Future Osteoarthritis Burden in Canada: A Population-Based Microsimulation Study. Arthritis Care Res (Hoboken). 2016 Aug;68(8):1098-105. doi: 10.1002/acr.22796. PubMed PMID: 26606744; PubMed Central PMCID: PMC5023424. https://www.ncbi.nlm.nih.gov/pubmed/26606744

 

Ratzlaff C, Zhang C, Korzan J, Josey L, Wong H, Cibere J, Prlic HM, Kopec JA, Esdaile JM, Li LC, Barber M, Forster BB. The validity of a non-radiologist reader in identifying cam and pincer femoroacetabular impingement (FAI) using plain radiography. Rheumatol Int. 2015 Oct 3. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/26433895

 

Hung A, Sayre EC, Guermazi A, Esdaile JM, Kopec JA, Thorne A, Singer J, Wong H, Nicolaou S, Cibere J. Association of Body Mass Index With Incidence and Progression of Knee Effusion on Magnetic Resonance Imaging and on Knee Examination. Arthritis Care Res (Hoboken). 2016 Apr;68(4):511-6. doi: 10.1002/acr.22714. PubMed PMID: 26359653. https://www.ncbi.nlm.nih.gov/pubmed/26359653

 

Hennessy DA, Flanagan WM, Tanuseputro P, Bennett C, Tuna M, Kopec J, Wolfson MC, Manuel DG. The Population Health Model (POHEM): an overview of rationale, methods and applications. Popul Health Metr. 2015 Sep 3;13:24. doi: 10.1186/s12963-015-0057-x. eCollection 2015. PubMed PMID: 26339201; PubMed Central PMCID: PMC4559325. https://www.ncbi.nlm.nih.gov/pubmed/26339201

 

Kopec JA, Sayre EC, Rogers P, Davis AM, Badley EM, Anis AH, Abrahamowicz M, Russell L, Rahman MM, Esdaile JM. Multiattribute health utility scoring for the computerized adaptive measure CAT-5D-QOL was developed and validated. J Clin Epidemiol. 2015 Oct;68(10):1213-20.e1-6. doi: 10.1016/j.jclinepi.2015.03.020. Epub 2015 Apr 14. PubMed PMID: 25990544. https://www.ncbi.nlm.nih.gov/pubmed/25990544

 

Rahman MM, Cibere J, Anis AH, Goldsmith CH, Kopec JA. Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study. Int J Rheumatol. 2014;2014:620920. doi: 10.1155/2014/620920. Epub 2014 Nov 4. PubMed PMID: 25538769; PubMed Central PMCID: PMC4236891. https://www.ncbi.nlm.nih.gov/pubmed/25538769

 

Liang MH, Couto MC, Duarte CC, Gall V, White P, Naides S, Schumacher HR Jr, Hwang AS, Holers VM, Deane KD, Gupta S, Ho IC, Finckh A, Kopec J, Choi CB, Sayre EC. An Internet-based technique for the identification of persons with symptoms of inflammatory polyarthritis of less than 12 weeks. Clin Rheumatol. 2015 Mar;34(3):465-70. doi: 10.1007/s10067-014-2796-7. Epub 2014 Oct 24. PubMed PMID: 25339123. https://www.ncbi.nlm.nih.gov/pubmed/25339123

 

Kopec JA, Ogonowski J, Rahman MM, Miazgowski T. Patient-Reported Outcomes in Women with Gestational Diabetes: a Longitudinal Study. Int J Behav Med. 2015 Apr;22(2):206-13. https://www.ncbi.nlm.nih.gov/pubmed/25106672

 

Badii M, Wade AN, Collins DR, Nicolaou S, Kobza BJ, Kopec JA. Comparison of lifts versus tape measure in determining leg length discrepancy. J Rheumatol. 2014 Aug;41(8):1689-94. doi: 10.3899/jrheum.131089. Epub 2014 Jul 15. PubMed PMID: 25028369. https://www.ncbi.nlm.nih.gov/pubmed/25028369

 

Rahman MM, Cibere J, Goldsmith CH, Anis AH, Kopec JA. Osteoarthritis incidence and trends in administrative health records from British Columbia, Canada. J Rheumatol. 2014 Jun;41(6):1147-54. doi: 10.3899/jrheum.131011. Epub 2014 Apr 15. PubMed PMID: 24737915. https://www.ncbi.nlm.nih.gov/pubmed/24737915

 

Crema MD, Cibere J, Sayre EC, Roemer FW, Wong H, Thorne A, Singer J, Esdaile JM, Marra MD, Kopec JA, Nicolaou S, Guermazi A. The relationship between subchondral sclerosis detected with MRI and cartilage loss in a cohort of subjects with knee pain: the knee osteoarthritis progression (KOAP) study. Osteoarthritis Cartilage. 2014 Apr;22(4):540-6. https://www.ncbi.nlm.nih.gov/pubmed/24508776

 

Izadnegahdar M, Singer J, Lee MK, Gao M, Thompson CR, Kopec J, Humphries KH. Do younger women fare worse? Sex differences in acute myocardial infarction hospitalization and early mortality rates over ten years. J Womens Health (Larchmt). 2014 Jan;23(1):10-7. doi: 10.1089/jwh.2013.4507. Epub 2013 Nov 8. PubMed PMID: 24206026. https://www.ncbi.nlm.nih.gov/pubmed/24206026

 

Davis EM, Lynd LD, Grubisic M, Kopec JA, Sayre EC, Cibere J, Esdaile J, Marra CA. Responsiveness of health state utility values in knee osteoarthritis. J Rheumatol. 2013 Dec;40(12):2075-82. doi: 10.3899/jrheum.130176. Epub 2013 Nov 1. PubMed PMID: 24187098. https://www.ncbi.nlm.nih.gov/pubmed/24187098

 

Sayre EC, Singer J, Thorne A, Wong H, Kopec JA, Esdaile JM, Guermazi A, Nicolaou S, Cibere J. Does moderate or severe nonspecific knee injury affect radiographic osteoarthritis incidence and progression? BMC Musculoskelet Disord. 2013 Oct 28;14:309. doi: 10.1186/1471-2474-14-309. PubMed PMID: 24164716; PubMed Central PMCID: PMC4231427. https://www.ncbi.nlm.nih.gov/pubmed/24164716

 

Rahman MM, Kopec JA, Anis AH, Cibere J, Goldsmith CH. Risk of cardiovascular disease in patients with osteoarthritis: a prospective longitudinal study. Arthritis Care Res (Hoboken). 2013 Dec;65(12):1951-8. doi: 10.1002/acr.22092. PubMed PMID: 23925995. https://www.ncbi.nlm.nih.gov/pubmed/23925995

 

Quon JA, Sobolev BG, Levy AR, Fisher CG, Bishop PB, Kopec JA, Dvorak MF, Schechter MT. The effect of waiting time on pain intensity after elective surgical lumbar discectomy. Spine J. 2013 Dec;13(12):1736-48. doi: 10.1016/j.spinee.2013.05.038. Epub 2013 Jul 11. PubMed PMID: 23850131. https://www.ncbi.nlm.nih.gov/pubmed/23850131

 

Rahman MM, Kopec JA, Cibere J, Goldsmith CH, Anis AH. The relationship between osteoarthritis and cardiovascular disease in a population health survey: a cross-sectional study. BMJ Open. 2013 May 14;3(5). pii: e002624. doi: 10.1136/bmjopen-2013-002624. PubMed PMID: 23674445; PubMed Central PMCID: PMC3657665. https://www.ncbi.nlm.nih.gov/pubmed/23674445

 

Li LC, Lineker S, Cibere J, Crooks VA, Jones CA, Kopec JA, Lear SA, Pencharz J, Rhodes RE, Esdaile JM. Capitalizing on the teachable moment: osteoarthritisphysical activity and exercise net for improving physical activity in early knee osteoarthritis. JMIR Res Protoc. 2013 May 9;2(1):e17. doi: 10.2196/resprot.2553. PubMed PMID: 23659903; PubMed Central PMCID: PMC3650932. https://www.ncbi.nlm.nih.gov/pubmed/23659903

 

Kopec JA, Sayre EC, Davis AM, Badley EM, Abrahamowicz M, Pouchot J, Sherlock L, Esdaile JM. Development of a paper-and-pencil semi-adaptive questionnaire for 5 domains of health-related quality of life (PAT-5D-QOL). Qual Life Res. 2013 Dec;22(10):2829-42. doi: 10.1007/s11136-013-0419-4. Epub 2013 May 8. PubMed PMID: 23653158. https://www.ncbi.nlm.nih.gov/pubmed/23653158

 

Kopec JA, Sayre EC, Schwartz TA, Renner JB, Helmick CG, Badley EM, Cibere J, Callahan LF, Jordan JM. Occurrence of radiographic osteoarthritis of the knee and hip among African Americans and whites: a population-based prospective cohort study. Arthritis Care Res (Hoboken). 2013 Jun;65(6):928-35. doi: 10.1002/acr.21924. PubMed PMID: 23281251; PubMed Central PMCID: PMC4206562. https://www.ncbi.nlm.nih.gov/pubmed/23281251

 

Bernatsky S, Lix L, O’Donnell S, Lacaille D; CANRAD Network (Kopec JA is among 50 collaborators). Consensus statements for the use of administrative health data in rheumatic disease research and surveillance. J Rheumatol. 2013 Jan;40(1):66-73. https://www.ncbi.nlm.nih.gov/pubmed/23118109

 

Kopec JA, Edwards K, Manuel DG, Rutter CM. Advances in microsimulation modeling of population health determinants, diseases, and outcomes. Epidemiology Research International 2012; Editorial, Article ID 584739, 3 pp. https://www.hindawi.com/journals/eri/2012/584739/

 

Sharif B, Kopec JA, Wong H, Finès P, Sayre EC, Liu RR, Wolfson MC. Uncertainty analysis in population-based disease microsimulation models. Epidemiology Research International 2012, Article ID 610405, 14 pp. https://www.hindawi.com/journals/eri/2012/610405/

 

Ratzlaff C, Koehoorn M, Cibere J, Kopec JA. Clinical validation of an internet-based questionnaire for ascertaining hip and knee osteoarthritis. Osteoarthritis Cartilage 2012;20(12):1568-73. https://www.ncbi.nlm.nih.gov/pubmed/22975023

 

Kopec JA, Colangelo LH, Land SR, Julian TB, Brown AM, Anderson SJ, Krag DN, Ashikaga T, Costatino JP, Wolmark N, Ganz PA. Relationship between arm morbidity and patient-reported outcomes following surgery in women with node-negative breast cancer: NSABP protocol B-32. J Support Oncol. 2013 Mar;11(1):22-30. PubMed PMID: 22951047; PubMed Central PMCID: PMC4131548. https://www.ncbi.nlm.nih.gov/pubmed/22951047

 

Ratzlaff CR, Koehoorn M, Cibere J, Kopec JA. Is lifelong knee joint force from work, home, and sport related to knee osteoarthritis? Int J Rheumatol. 2012;2012:584193. doi: 10.1155/2012/584193. Epub 2012 Jul 17. PubMed PMID: 22848225; PubMed Central PMCID: PMC3405641. https://www.ncbi.nlm.nih.gov/pubmed/22848225

 

Kidwell KM, Yothers G, Ganz PA, Land SR, Ko CY, Cecchini RS, Kopec JA, Wolmark N. Long-term neurotoxicity effects of oxaliplatin added to fluorouracil and leucovorin as adjuvant therapy for colon cancer: results from National Surgical Adjuvant Breast and Bowel Project trials C-07 and LTS-01. Cancer. 2012 Nov 15;118(22):5614-22. doi: 10.1002/cncr.27593. Epub 2012 May 8. PubMed PMID: 22569841; PubMed Central PMCID: PMC4131537. https://www.ncbi.nlm.nih.gov/pubmed/22569841

 

Lung R, O’Brien J, Grebenyuk J, Forster BB, De Vera M, Kopec J, Ratzlaff C, Garbuz D, Prlic H, Esdaile JM. The prevalence of radiographic femoroacetabular impingement in younger individuals undergoing total hip replacement for osteoarthritis. Clin Rheumatol. 2012 Aug;31(8):1239-42. doi: 10.1007/s10067-012-1981-9. Epub 2012 May 3. PubMed PMID: 22552857. https://www.ncbi.nlm.nih.gov/pubmed/22552857

 

Dufton JA, Bruni SG, Kopec JA, Cassidy JD, Quon J. Delayed recovery in patients with whiplash-associated disorders. Injury 2012 Jul;43(7):1141-7. https://www.ncbi.nlm.nih.gov/pubmed/22475071

 

De Vera MA, Choi H, Abrahamowicz M, Kopec J, Lacaille D. Impact of statin discontinuation on mortality in patients with rheumatoid arthritis – A population-based study. Arthritis Care Res (Hoboken). 2012 Jun;64(6):809-16. https://www.ncbi.nlm.nih.gov/pubmed/22467274

 

Sawatzky R, Ratner PA, Kopec JA, Zumbo BD. Latent variable mixture models: a promising approach for the validation of patient reported outcomes. Qual Life Res 2012 May;21(4):637-50 https://www.ncbi.nlm.nih.gov/pubmed/21814876

 

Crema MD, Guermazi A, Sayre EC, Roemer FW, Wong H, Thorne A, Singer J, Esdaile JM, Marra MD, Kopec JA, Nicolaou S, Cibere J. The association of magnetic resonance imaging (MRI)-detected structural pathology of the knee with crepitus in a population-based cohort with knee pain: the MoDEKO study. Osteoarthritis Cartilage. 2011 Dec;19(12):1429-32. https://www.ncbi.nlm.nih.gov/pubmed/21945851

 

Li LC, Sayre EC, Kopec JA, Esdaile JM, Bar S, Cibere J. Quality of Nonpharmacological Care in the Community for People with Knee and Hip Osteoarthritis. J Rheumatol. 2011 Oct;38(10):2230-7. https://www.ncbi.nlm.nih.gov/pubmed/21807776

 

Zhang W, Bansback N, Kopec JA, Anis AH. Measuring time input loss among patients with rheumatoid arthritis: Validity and reliability of the valuation of lost productivity questionnaire. J Occup Environ Med. 2011 May;53(5):530-6 https://www.ncbi.nlm.nih.gov/pubmed/21508868

 

De Vera MA, Choi H, Abrahamowicz M, Kopec JA, Goycochea-Robles MV, Lacaille D. Statin discontinuation and risk of acute myocardial infarction in patients with rheumatoid arthritis: a population-based cohort study. Ann Rheum Dis. 2011 Jun;70(6):1020-4. https://www.ncbi.nlm.nih.gov/pubmed/21378405

 

Ip S, Sayre EC, Guermazi A, Nicolaou S, Wong H, Thorne A, Singer J, Kopec JA, Esdaile JM, Cibere J. Frequency of Bone Marrow Lesions and Association with Pain Severity: Results from a Population-based Symptomatic Knee Cohort.  J Rheumatol. 2011 Jun;38(6):1079-85. https://www.ncbi.nlm.nih.gov/pubmed/21362771

 

Cibere J, Sayre EC, Guermazi A, Nicolaou S, Kopec JA, Esdaile JM, Thorne A, Singer J, Wong H. Natural history of cartilage damage and osteoarthritis progression on magnetic resonance imaging in a population-based cohort with knee pain. Osteoarthritis Cartilage. 2011 Jun;19(6):683-8. https://www.ncbi.nlm.nih.gov/pubmed/21329760

 

Ratzlaff CR, Steininger G, Doerfling P, Koehoorn M, Cibere J, Liang MH, Wilson DR, Esdaile JM, Kopec JA. Influence of lifetime hip joint force on the risk of self-reported hip osteoarthritis: a community-based cohort study. Osteoarthritis Cartilage. 2011 Apr;19(4):389-98. https://www.ncbi.nlm.nih.gov/pubmed/21255666

 

Rahman MM, Kopec JA, Sayre EC, Greidanus NV, Aghajanian J, Anis AH, Cibere J, Jordan JM, Badley EM Effect of Sociodemographic Factors on Surgical Consultations and Hip or Knee Replacements Among Patients with Osteoarthritis in British Columbia, Canada. J Rheumatol. 2011, Mar;38(3):503-9. https://www.ncbi.nlm.nih.gov/pubmed/21078721

 

Kopec JA, Finès P, Manuel DG, Buckeridge DL, Flanagan WM, Oderkirk J, Abrahamowicz M, Harper S, Sharif B, Okhmatovskaia A, Sayre EC, Rahman MM, Wolfson MC. Validation of population-based disease simulation models: A review of concepts and methods.  BMC Public Health 2010 Nov 18;10:710. https://www.ncbi.nlm.nih.gov/pubmed/21087466

 

De Vera MA, Ratzlaff C, Doerfling P, Kopec J. Reliability and validity of an internet-based questionnaire measuring lifetime physical activity. Am J Epidemiol. 2010 Nov 15;172(10):1190-8. doi: 10.1093/aje/kwq273. Epub 2010 Sep 28. PubMed PMID: 20876666; PubMed Central PMCID: PMC2970783. https://www.ncbi.nlm.nih.gov/pubmed/20876666

 

Noonan VK, Kopec JA, Noreau L, Singer J, Mâsse LC, Dvorak MF. Comparing the reliability of five participation instruments in persons with spinal conditions. J Rehabil Med. 2010 Sep;42(8):735-43. doi: 10.2340/16501977-0583. PubMed PMID: 20809055. https://www.ncbi.nlm.nih.gov/pubmed/20809055

 

Noonan VK, Kopec JA, Noreau L, Singer J, Mâsse LC, Zhang H, Dvorak MF. Comparing the validity of five participation instruments in persons with spinal conditions. J Rehabil Med. 2010 Sep;42(8):724-34. doi: 10.2340/16501977-0584. PubMed PMID: 20809054. https://www.ncbi.nlm.nih.gov/pubmed/20809054

 

Doerfling P, Kopec JA, Liang MH, Esdaile JM. The effect of cash lottery on response rates to an online health survey among members of the Canadian Association of Retired Persons: a randomized experiment. Can J Public Health. 2010 May-Jun;101(3):251-4. PubMed PMID: 20737820. https://www.ncbi.nlm.nih.gov/pubmed/20737820

 

Land SR, Kopec JA, Julian TB, Brown AM, Anderson SJ, Krag DN, Christian NJ, Costantino JP, Wolmark N, Ganz PA. Patient-reported outcomes in sentinel node-negative adjuvant breast cancer patients receiving sentinel-node biopsy or axillary dissection: National Surgical Adjuvant Breast and Bowel Project phase III protocol B-32. J Clin Oncol. 2010 Sep 1;28(25):3929-36. doi: 10.1200/JCO.2010.28.2491. Epub 2010 Aug 2. Erratum in: J Clin Oncol. 2010 Dec 20;28(36):5350. PubMed PMID: 20679600; PubMed Central PMCID: PMC2940391. https://www.ncbi.nlm.nih.gov/pubmed/20679600

 

Cibere J, Zhang H, Thorne A, Wong H, Singer J, Kopec JA, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Association of clinical findings with pre-radiographic and radiographic knee osteoarthritis in a population-based study. Arthritis Care Res (Hoboken). 2010 Dec;62(12):1691-8. doi: 10.1002/acr.20314. Epub 2010 Jul 27. PubMed PMID: 20665737. https://www.ncbi.nlm.nih.gov/pubmed/20665737

 

Ratzlaff CR, Doerfling P, Steininger G, Koehoorn M, Cibere J, Liang M, Wilson DR, Esdaile J, Kopec J. Lifetime trajectory of physical activity according to energy expenditure and joint force. Arthritis Care Res (Hoboken). 2010 Oct;62(10):1452-9. doi: 10.1002/acr.20243. PubMed PMID: 20506184. https://www.ncbi.nlm.nih.gov/pubmed/20506184

 

Sayre EC, Li LC, Kopec JA, Esdaile JM, Bar S, Cibere J. The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis. PLoS One. 2010 May 3;5(5):e10470. doi: 10.1371/journal.pone.0010470. PubMed PMID: 20454665; PubMed Central PMCID: PMC2862713. https://www.ncbi.nlm.nih.gov/pubmed/20454665

 

Sayre EC, Jordan JM, Cibere J, Murphy L, Schwartz TA, Helmick CG, Renner JB, Rahman MM, Aghajanian J, Kang W, Badley EM, Kopec JA. Quantifying the association of radiographic osteoarthritis in knee or hip joints with other knees or hips: the Johnston County Osteoarthritis Project. J Rheumatol. 2010 Jun;37(6):1260-5. doi: 10.3899/jrheum.091154. Epub 2010 Apr 15. PubMed PMID: 20395646. https://www.ncbi.nlm.nih.gov/pubmed/20395646

 

Grindrod KA, Marra CA, Colley L, Cibere J, Tsuyuki RT, Esdaile JM, Gastonguay L, Kopec J. After patients are diagnosed with knee osteoarthritis, what do they do? Arthritis Care Res (Hoboken). 2010 Apr;62(4):510-5. doi: 10.1002/acr.20170. PubMed PMID: 20391506. https://www.ncbi.nlm.nih.gov/pubmed/20391506

 

Higgins J, Finch LE, Kopec J, Mayo NE. Development and initial psychometric evaluation of an item bank created to measure upper extremity function in persons with stroke. J Rehabil Med. 2010 Feb;42(2):170-8. doi: 10.2340/16501977-0501. PubMed PMID: 20140414. https://www.ncbi.nlm.nih.gov/pubmed/20140414

 

Sawatzky R, Ratner PA, Johnson JL, Kopec JA, Zumbo BD. Self-reported physical and mental health status and quality of life in adolescents: a latent variable mediation model. Health Qual Life Outcomes. 2010 Feb 3;8:17. doi: 10.1186/1477-7525-8-17. PubMed PMID: 20128913; PubMed Central PMCID: PMC2829530. https://www.ncbi.nlm.nih.gov/pubmed/20128913

 

De Vera MA, Rahman MM, Bhole V, Kopec JA, Choi HK. Independent impact of gout on the risk of acute myocardial infarction among elderly women: a population-based study. Ann Rheum Dis. 2010 Jun;69(6):1162-4. doi: 10.1136/ard.2009.122770. Epub 2010 Feb 2. PubMed PMID: 20124358; PubMed Central PMCID: PMC3142935. https://www.ncbi.nlm.nih.gov/pubmed/20124358

 

Noonan VK, Kopec JA, Noreau L, Singer J, Chan A, Mâsse LC, Dvorak MF. Comparing the content of participation instruments using the international classification of functioning, disability and health. Health Qual Life Outcomes. 2009 Nov 13;7:93. doi: 10.1186/1477-7525-7-93. PubMed PMID: 19909555; PubMed Central PMCID: PMC2785762. https://www.ncbi.nlm.nih.gov/pubmed/19909555

 

*Kopec JA, Sayre EC, Flanagan WM, Fines P, Cibere J, Rahman MM, Bansback NJ, Anis AH, Jordan JM, Sobolev B, Aghajanian J, Kang W, Greidanus NV, Garbuz DS, Hawker GA, Badley EM. Development of a population-based microsimulation model of osteoarthritis in Canada. Osteoarthritis Cartilage. 2010;18(3):303-11. https://www.ncbi.nlm.nih.gov/pubmed/19879999

 

Sawatzky R, Ratner PA, Johnson JL, Kopec JA, Zumbo BD. Sample Heterogeneity and the Measurement Structure of the Multidimensional Students’ Life Satisfaction Scale. Soc Indic Res. 2009 Nov 1;94(2):273-296. PubMed PMID: 27867252; PubMed Central PMCID: PMC5112029. https://www.ncbi.nlm.nih.gov/pubmed/27867252

 

Quon JA, Levy AR, Sobolev B, Fisher CG, Kopec JA, Bishop P, Dvorak MF, Schechter MT. The effect of compensation status on waiting time for elective surgical lumbar discectomy. Spine (Phila Pa 1976). 2009 Sep 1;34(19):2052-9. doi: 10.1097/BRS.0b013e3181b2f233. PubMed PMID: 19730213. https://www.ncbi.nlm.nih.gov/pubmed/19730213

 

Noonan VK, Kopec JA, Noreau L, Singer J, Dvorak MF. A review of participation instruments based on the International Classification of Functioning, Disability and Health. Disabil Rehabil. 2009;31(23):1883-901. doi: 10.1080/09638280902846947. Review. PubMed PMID: 19479505. https://www.ncbi.nlm.nih.gov/pubmed/19479505

 

Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, Kraus VB, Way A, Thorne A, Wong H, Singer J, Kopec J, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. Arthritis Rheum. 2009 May;60(5):1372-80. doi: 10.1002/art.24473. PubMed PMID: 19404937; PubMed Central PMCID: PMC4724193. https://www.ncbi.nlm.nih.gov/pubmed/19404937

 

Arthur AB, Kopec JA, Klinkhoff AV, Adam PM, Carr SL, Prince JM, Dumont KE, Nigg CR. Readiness to manage arthritis: a pilot study using a stages-of-change measure for arthritis rehabilitation. Rehabil Nurs. 2009 Mar-Apr;34(2):64-73, 84. PubMed PMID: 19271660. https://www.ncbi.nlm.nih.gov/pubmed/19271660

 

Sayre EC, Bunting PS, Kopec JA. Reliability of self-report versus chart-based prostate cancer, PSA, DRE and urinary symptoms. Can J Urol. 2009 Feb;16(1):4463-71. PubMed PMID: 19222884. https://www.ncbi.nlm.nih.gov/pubmed/19222884

 

De Vera M, Rahman MM, Rankin J, Kopec J, Gao X, Choi H. Gout and the risk of Parkinson’s disease: a cohort study. Arthritis Rheum. 2008 Nov 15;59(11):1549-54. doi: 10.1002/art.24193. PubMed PMID: 18975349. https://www.ncbi.nlm.nih.gov/pubmed/18975349

 

McTaggart-Cowan HM, Shi P, Fitzgerald JM, Anis AH, Kopec JA, Bai TR, Soon JA, Lynd LD. An evaluation of patients’ willingness to trade symptom-free days for asthma-related treatment risks: a discrete choice experiment. J Asthma. 2008 Oct;45(8):630-8. doi: 10.1080/02770900802126990. PubMed PMID: 18951253. https://www.ncbi.nlm.nih.gov/pubmed/18951253

 

Bansback N, Harrison M, Brazier J, Davies L, Kopec J, Marra C, Symmons D, Anis A. Health state utility values: a description of their development and application for rheumatic diseases. Arthritis Rheum. 2008 Jul 15;59(7):1018-26. doi: 10.1002/art.23813. Review. PubMed PMID: 18576311. https://www.ncbi.nlm.nih.gov/pubmed/18576311

 

Kopec JA, Rahman MM, Sayre EC, Cibere J, Flanagan WM, Aghajanian J, Anis AH, Jordan JM, Badley EM. Trends in physician-diagnosed osteoarthritis incidence in an administrative database in British Columbia, Canada, 1996-1997 through 2003-2004. Arthritis Rheum. 2008 Jul 15;59(7):929-34. doi: 10.1002/art.23827. PubMed PMID: 18576288. https://www.ncbi.nlm.nih.gov/pubmed/18576288

 

Kopec JA, Sayre EC. ROC area discrimination (ROCAD) curve: a new method of evaluating the discriminating ability of ordinal scales. J Clin Epidemiol. 2008 Oct;61(10):997-1003.e1. doi: 10.1016/j.jclinepi.2007.11.016. Epub 2008 Jun 9. PubMed PMID: 18539430. https://www.ncbi.nlm.nih.gov/pubmed/18539430

 

Noonan VK, Kopec JA, Zhang H, Dvorak MF. Impact of associated conditions resulting from spinal cord injury on health status and quality of life in people with traumatic central cord syndrome. Arch Phys Med Rehabil. 2008 Jun;89(6):1074-82. doi: 10.1016/j.apmr.2007.10.041. PubMed PMID: 18503802. https://www.ncbi.nlm.nih.gov/pubmed/18503802

 

Kopec JA, Badii M, McKenna M, Lima VD, Sayre EC, Dvorak M. Computerized adaptive testing in back pain: validation of the CAT-5D-QOL. Spine (Phila Pa 1976). 2008 May 20;33(12):1384-90. doi: 10.1097/BRS.0b013e3181732a3b. PubMed PMID: 18496353. https://www.ncbi.nlm.nih.gov/pubmed/18496353

 

Pouchot J, Kherani RB, Brant R, Lacaille D, Lehman AJ, Ensworth S, Kopec J, Esdaile JM, Liang MH. Determination of the minimal clinically important difference for seven fatigue measures in rheumatoid arthritis. J Clin Epidemiol. 2008 Jul;61(7):705-13. doi: 10.1016/j.jclinepi.2007.08.016. Epub 2008 Mar 21. PubMed PMID: 18359189; PubMed Central PMCID: PMC2486378. https://www.ncbi.nlm.nih.gov/pubmed/18359189

 

Goligher EC, Pouchot J, Brant R, Kherani RB, Aviña-Zubieta JA, Lacaille D, Lehman AJ, Ensworth S, Kopec J, Esdaile JM, Liang MH. Minimal clinically important difference for 7 measures of fatigue in patients with systemic lupus erythematosus. J Rheumatol. 2008 Apr;35(4):635-42. Epub 2008 Mar 1. PubMed PMID: 18322987. https://www.ncbi.nlm.nih.gov/pubmed/18322987

 

Cibere J, Thorne A, Bellamy N, Greidanus N, Chalmers A, Mahomed N, Shojania K, Kopec J, Esdaile JM. Reliability of the hip examination in osteoarthritis: effect of standardization. Arthritis Rheum. 2008 Mar 15;59(3):373-81. doi: 10.1002/art.23310. PubMed PMID: 18311750. https://www.ncbi.nlm.nih.gov/pubmed/18311750

 

McTaggart-Cowan HM, Marra CA, Yang Y, Brazier JE, Kopec JA, FitzGerald JM, Anis AH, Lynd LD. The validity of generic and condition-specific preference-based instruments: the ability to discriminate asthma control status. Qual Life Res. 2008 Apr;17(3):453-62. doi: 10.1007/s11136-008-9309-6. Epub 2008 Feb 15. PubMed PMID: 18274882. https://www.ncbi.nlm.nih.gov/pubmed/18274882

 

Dhalla S, Kopec JA. The CAGE questionnaire for alcohol misuse: a review of reliability and validity studies. Clin Invest Med. 2007;30(1):33-41. Review. PubMed PMID: 17716538. https://www.ncbi.nlm.nih.gov/pubmed/17716538

 

Kopec JA, Richardson CG, Llewellyn-Thomas H, Klinkhoff A, Carswell A, Chalmers A. Probabilistic threshold technique showed that patients’ preferences for specific trade-offs between pain relief and each side effect of treatment in osteoarthritis varied. J Clin Epidemiol. 2007 Sep;60(9):929-38. Epub 2007 May 8. PubMed PMID: 17689809. https://www.ncbi.nlm.nih.gov/pubmed/17689809

 

Richardson CG, Chalmers A, Llewellyn-Thomas HA, Klinkhoff A, Carswell A, Kopec JA. Pain relief in osteoarthritis: patients’ willingness to risk medication-induced gastrointestinal, cardiovascular, and cerebrovascular complications. J Rheumatol. 2007 Jul;34(7):1569-75. Epub 2007 Jun 1. PubMed PMID: 17552039. https://www.ncbi.nlm.nih.gov/pubmed/17552039

 

Land SR, Kopec JA, Cecchini RS, Ganz PA, Wieand HS, Colangelo LH, Murphy K, Kuebler JP, Seay TE, Needles BM, Bearden JD 3rd, Colman LK, Lanier KS, Pajon ER Jr, Cella D, Smith RE, O’Connell MJ, Costantino JP, Wolmark N. Neurotoxicity from oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: NSABP C-07. J Clin Oncol. 2007 Jun 1;25(16):2205-11. Epub 2007 Apr 30. PubMed PMID: 17470850. https://www.ncbi.nlm.nih.gov/pubmed/17470850

 

Kopec JA, Yothers G, Ganz PA, Land SR, Cecchini RS, Wieand HS, Lembersky BC, Wolmark N. Quality of life in operable colon cancer patients receiving oral compared with intravenous chemotherapy: results from National Surgical Adjuvant Breast and Bowel Project Trial C-06. J Clin Oncol. 2007 Feb 1;25(4):424-30. Erratum in: J Clin Oncol. 2007 Dec 1;25(34):5540-1. PubMed PMID: 17264338. https://www.ncbi.nlm.nih.gov/pubmed/17264338

 

Kopec JA, Rahman MM, Berthelot JM, Le Petit C, Aghajanian J, Sayre EC, Cibere J, Anis AH, Badley EM. Descriptive epidemiology of osteoarthritis in British Columbia, Canada. J Rheumatol. 2007 Feb;34(2):386-93. Epub 2006 Dec 15. PubMed PMID: 17183616. https://www.ncbi.nlm.nih.gov/pubmed/17183616

 

Dufton JA, Kopec JA, Wong H, Cassidy JD, Quon J, McIntosh G, Koehoorn M. Prognostic factors associated with minimal improvement following acute whiplash-associated disorders. Spine (Phila Pa 1976). 2006 Sep 15;31(20):E759-65; discussion E766. PubMed PMID: 16985445. https://www.ncbi.nlm.nih.gov/pubmed/16985445

 

Kopec JA, Sayre EC, Davis AM, Badley EM, Abrahamowicz M, Sherlock L, Williams JI, Anis AH, Esdaile JM. Assessment of health-related quality of life in arthritis: conceptualization and development of five item banks using item response theory. Health Qual Life Outcomes. 2006 Jun 2;4:33. PubMed PMID: 16749932; PubMed Central PMCID: PMC1550394. https://www.ncbi.nlm.nih.gov/pubmed/16749932

 

Kopec JA, Sayre EC. Stressful experiences in childhood and chronic back pain in the general population. Clin J Pain. 2005 Nov-Dec;21(6):478-83. PubMed PMID: 16215332. https://www.ncbi.nlm.nih.gov/pubmed/16215332