Aslam Anis

Senior Research Scientist of Health Economics, PhD, FCAHS

 

Appointments

  • Professor, School of Population and Public Health, University of British Columbia
  • Director, Centre for Health Evaluation and Outcome Sciences (CHÉOS)
  • National Director, CIHR Canadian HIV Trials Network (CTN)

 

Research Interests

  • Health Economics

 

Dr. Aslam Anis is a Professor in the School of Population and Public Health (SPPH) at the University of British Columbia (UBC).  Since 2006, Dr. Anis has been the Director of the Centre for Health Evaluation and Outcomes Sciences (CHÉOS), a renowned multidisciplinary health outcomes research unit within Providence Health Care Research Institute in Vancouver, Canada.  He is also the National Director of the CIHR Canadian HIV Trials Network (CTN) and Senior Scientist, Arthritis Research Canada.

As one of Canada’s most distinguished health economists, Dr. Anis has conducted numerous studies assessing the impact of various types of regulatory instruments and policies on the pharmaceutical marketplace in Canada. He currently oversees economic analysis and health services research activities across Providence Health Care, with scholars who trained under Dr. Anis operating across CHÉOS, CTN, the Heart and Lung Institute (HLI), and the Collaboration for Outcomes Research and Evaluation (CORE) in UBC’s Faculty of Pharmaceutical Sciences.

Learn more

In a career spanning more than 25 years, Dr. Anis has achieved international recognition for his seminal contributions toward the development of scientific knowledge across multiple and diverse health disciplines. His work has been instrumental in shaping economic policies in Canada, notably those governing access to anti-retroviral therapy (ART) for persons living with HIV/AIDS. Dr. Anis was among the first scholars worldwide to demonstrate the cost-effectiveness of ART and he has published widely in the peer-reviewed literature on health resource use and costs among HIV/AIDS patients treated and not treated with ART. Research by Dr. Anis in the area of pharmaceutical pricing policies in Canada has also attracted worldwide attention since the 1990s and he continues to publish on the economic impact of changing drug price regulations. Dr. Anis’s expertise in health economics as pertaining to the pharmaceutical industry encompasses the relationship between government regulations and corporate behaviour, competition policy, patent infringement and international trade in pharmaceuticals. Dr. Anis has extensive experience conducting cost-effectiveness studies of new drugs especially biologic therapies for the treatment of inflammatory arthritis and he regularly consults with industry and governments in the context of formulary approval decisions. More recently, Dr. Anis has collaborated on groundbreaking work in B.C. demonstrating the safety and cost-effectiveness of alternative treatment for people with chronic opioid use disorder.

From 2006 to 2009, Dr. Anis served as a member of the Canadian Institute for Health Research (CIHR) HIV/AIDS Research Advisory Committee, whose mandate is to make recommendations to the Institute of Infection and Immunity regarding research priorities for HIV/AIDS. Dr. Anis also served on the Public Health Agency of Canada and CIHR Special Planning Committee to review the Federal Initiative on HIV/AIDS in Canada from 2006 to 2007. Provincially, Dr. Anis has served in various capacities at the Michael Smith Foundation for Health Research (MSFHR) including its Research Advisory Council. Dr. Anis consults widely with federal, provincial, and private agencies, including Health Canada, the BC Ministry of Health, Industry Canada, the Canadian Medical Association, and Canadian and international pharmaceutical manufacturers. He actively participates in several knowledge transfer activities, including participation on government panels and involvement with consumer associations. Dr. Anis has published more than 220 peer-reviewed papers and garnered in excess of $180 million in peer-reviewed research funding.

Publications

Joyce VR, Sun H, Barnett PG, Bansback N, Griffin SC, Bayoumi AM, Anis AH, Sculpher M, Cameron W, Brown ST, Holodniy M, Owens DK. Mapping MOS_HIV to HUI3 and EQ-5D-3L in Patients with HIV. MDM Policy & Practice. 2017. 2(2): 1-13. Doi: 10.1177/2381468317716440.

 

Harvard S, Guh D, Bansback N, Richette P, Saraux A, Fautrel B, Anis AH. Adherence to Antitumor Necrosis Factor Use Recommendations in Spondyloarthritis: Measurement and Effect in the DESIR Cohort. J Rheumatol. 2017 Jul 1. pii: jrheum.161399. doi: 10.3899/jrheum.161399. [Epub ahead of print] PubMed PMID: 28668809. https://www.ncbi.nlm.nih.gov/pubmed/28668809

 

Oviedo-Joekes E, Palis H, Guh D, Marchand K, Brissette S, Lock K, MacDonald S, Harrison S, Anis AH, Krausz M, Marsh DC, Schechter MT. Characteristics and response to treatment among Indigenous people receiving injectable diacetylmorphine or hydromorphone in a randomised controlled trial for the treatment of long-term opioid dependence. Drug Alcohol Rev. 2017 Jun 8. doi: 10.1111/dar.12573. [Epub ahead of print] PubMed PMID: 28593748. https://www.ncbi.nlm.nih.gov/pubmed/28593748

 

Bansback N, Phibbs CS, Sun H, O’Dell JR, Brophy M, Keystone EC, Leatherman S, Mikuls TR, Anis AH; CSP 551 RACAT Investigators. Triple Therapy Versus Biologic Therapy for Active Rheumatoid Arthritis: A Cost-Effectiveness Analysis. Ann Intern Med. 2017 Jul 4;167(1):8-16. doi: 10.7326/M16-0713. Epub 2017 May 30. PubMed PMID: 28554192. https://www.ncbi.nlm.nih.gov/pubmed/28554192

 

Palis H, Marchand K, Guh D, Brissette S, Lock K, MacDonald S, Harrison S, Anis AH, Krausz M, Marsh DC, Schechter MT, Oviedo-Joekes E. Men’s and women’s response to treatment and perceptions of outcomes in a randomized controlled trial of injectable opioid assisted treatment for severe opioid use disorder. Subst Abuse Treat Prev Policy. 2017 May 19;12(1):25. doi: 10.1186/s13011-017-0110-9. PubMed PMID: 28526048; PubMed Central PMCID: PMC5437624. https://www.ncbi.nlm.nih.gov/pubmed/28526048

 

Oviedo-Joekes E, Brissette S, MacDonald S, Guh D, Marchand K, Jutha S, Harrison S, Janmohamed A, Zhang DZ, Anis AH, Krausz M, Marsh DC, Schechter MT. Safety profile of injectable hydromorphone and diacetylmorphine for long-term severe opioid use disorder. Drug Alcohol Depend. 2017 Jul 1;176:55-62. doi: 10.1016/j.drugalcdep.2017.02.021. Epub 2017 May 10. PubMed PMID: 28521199. https://www.ncbi.nlm.nih.gov/pubmed/28521199

 

Sharif B, Wong H, Anis AH, Kopec JA. A Practical ANOVA Approach for Uncertainty Analysis in Population-Based Disease Microsimulation Models. Value Health. 2017 Apr;20(4):710-717. doi: 10.1016/j.jval.2017.01.002. Epub 2017 Mar 11. PubMed PMID: 28408016. https://www.ncbi.nlm.nih.gov/pubmed/28408016

 

Rahman MM, Kopec JA, Goldsmith CH, Anis AH, Cibere J. Validation of Administrative Osteoarthritis Diagnosis Using a Clinical and Radiological Population-Based Cohort. Int J Rheumatol. 2016;2016:6475318. doi: 10.1155/2016/6475318. Epub 2016 Dec 29. PubMed PMID: 28127309; PubMed Central PMCID: PMC5227164. https://www.ncbi.nlm.nih.gov/pubmed/28127309

 

Zhang W, Sun H, Woodcock S, Anis AH. Valuing productivity loss due to absenteeism: firm-level evidence from a Canadian linked employer-employee survey. Health Econ Rev. 2017 Dec;7(1):3. doi: 10.1186/s13561-016-0138-y. Epub 2017 Jan 19. PubMed PMID: 28105591; PubMed Central PMCID: PMC5247392. https://www.ncbi.nlm.nih.gov/pubmed/28105591

 

Zhang W, Sun H, Guh D, Anis AH. The impact of price-cap regulations on market entry by generic pharmaceutical firms. Expert Rev Pharmacoecon Outcomes Res. 2017 Apr;17(2):231-238. doi: 10.1080/14737167.2017.1271717. Epub 2016 Dec 27. PubMed PMID: 27936981. https://www.ncbi.nlm.nih.gov/pubmed/27936981

 

Stenstrom R, Ling D, Grafstein E, Barrios R, Sherlock C, Gustafson R, Osati F, Poureslami I, Anis A. Prevalence of HIV infection and acceptability of point-of-care testing in a Canadian inner-city emergency department. Can J Public Health. 2016 Oct 20;107(3):e291-e295. doi: 10.17269/cjph.107.5318. PubMed PMID: 27763845. https://www.ncbi.nlm.nih.gov/pubmed/27763845

 

Zhang W, Bansback N, Sun H, Pedersen R, Kotak S, Anis AH. Impact of etanercept tapering on work productivity in patients with early rheumatoid arthritis: results from the PRIZE study. RMD Open. 2016 Jul 7;2(2):e000222. doi: 10.1136/rmdopen-2015-000222. eCollection 2016. PubMed PMID: 27486524; PubMed Central PMCID: PMC4947791. https://www.ncbi.nlm.nih.gov/pubmed/27486524

 

Harrison M, Milbers K, Mihic T, Anis AH. Incentives in Rheumatology: the Potential Contribution of Physician Responses to Financial Incentives, Public Reporting, and Treatment Guidelines to Health Care Sustainability. Curr Rheumatol Rep. 2016 Jul;18(7):42. doi: 10.1007/s11926-016-0596-6. Review. PubMed PMID: 27240436. https://www.ncbi.nlm.nih.gov/pubmed/27240436

 

Zhang W, Guh D, Sun H, Marra CA, Lynd LD, Anis AH. The Impact of Price-cap Regulations on Exit by Generic Pharmaceutical Firms. Med Care. 2016 Sep;54(9):884-90. doi: 10.1097/MLR.0000000000000577. PubMed PMID: 27213540. https://www.ncbi.nlm.nih.gov/pubmed/27213540

 

Sharif B, Kopec JA, Wong H, Anis AH. Distribution and Drivers of Average Direct Cost of Osteoarthritis in Canada From 2003 to 2010. Arthritis Care Res (Hoboken). 2017 Feb;69(2):243-251. doi: 10.1002/acr.22933. PubMed PMID: 27159532. https://www.ncbi.nlm.nih.gov/pubmed/27159532

 

Harvard S, Guh D, Bansback N, Richette P, Dougados M, Anis A, Fautrel B. Costs of early spondyloarthritis: estimates from the first 3 years of the DESIR cohort. RMD Open. 2016 Apr 4;2(1):e000230. doi: 10.1136/rmdopen-2015-000230. eCollection 2016. PubMed PMID: 27099778; PubMed Central PMCID: PMC4823587. https://www.ncbi.nlm.nih.gov/pubmed/27099778

 

Oviedo-Joekes E, Guh D, Brissette S, Marchand K, MacDonald S, Lock K, Harrison S, Janmohamed A, Anis AH, Krausz M, Marsh DC, Schechter MT. Hydromorphone Compared With Diacetylmorphine for Long-term Opioid Dependence: A Randomized Clinical Trial. JAMA Psychiatry. 2016 May 1;73(5):447-55. doi: 10.1001/jamapsychiatry.2016.0109. PubMed PMID: 27049826. https://www.ncbi.nlm.nih.gov/pubmed/27049826

 

Bansback N, Keystone E, O’Dell J, Phibbs CS, Hannagan K, Brophy M, Anis A. Making smart investment decisions in clinical research. Trials. 2015 Dec 29;16:590. doi: 10.1186/s13063-015-1123-1. PubMed PMID: 26712327; PubMed Central PMCID: PMC4693420. https://www.ncbi.nlm.nih.gov/pubmed/26712327

 

Zhang W, Sun H, Woodcock S, Anis A. Illness related wage and productivity losses: Valuing ‘presenteeism’. Soc Sci Med. 2015 Dec;147:62-71. doi: 10.1016/j.socscimed.2015.10.056. Epub 2015 Oct 26. PubMed PMID: 26547046. https://www.ncbi.nlm.nih.gov/pubmed/26547046

 

Zhang W, Bansback N, Sun H, Pedersen R, Kotak S, Anis AH. Estimating the monetary value of the annual productivity gained in patients with early rheumatoid arthritis receiving etanercept plus methotrexate: interim results from the PRIZE study. RMD Open. 2015 Apr 8;1(1):e000042. doi: 10.1136/rmdopen-2014-000042. eCollection 2015. PubMed PMID: 26535135; PubMed Central PMCID: PMC4613161. https://www.ncbi.nlm.nih.gov/pubmed/26535135

 

Kopec JA, Sayre EC, Rogers P, Davis AM, Badley EM, Anis AH, Abrahamowicz M, Russell L, Rahman MM, Esdaile JM. Multiattribute health utility scoring for the computerized adaptive measure CAT-5D-QOL was developed and validated. J Clin Epidemiol. 2015 Oct;68(10):1213-20.e1-6. doi: 10.1016/j.jclinepi.2015.03.020. Epub 2015 Apr 14. PubMed PMID: 25990544. https://www.ncbi.nlm.nih.gov/pubmed/25990544

 

Harvard S, Gossec L, Pham T, Richette P, Dougados M, Anis A, Fautrel B. Measurable definitions of ankylosing spondylitis management recommendations are needed for use in observational studies. Joint Bone Spine. 2016 Jan;83(1):101-3. doi: 10.1016/j.jbspin.2015.01.019. Epub 2015 Mar 13. PubMed PMID: 25776447. https://www.ncbi.nlm.nih.gov/pubmed/25776447

 

Rahman MM, Cibere J, Anis AH, Goldsmith CH, Kopec JA. Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study. Int J Rheumatol. 2014;2014:620920. doi: 10.1155/2014/620920. Epub 2014 Nov 4. PubMed PMID: 25538769; PubMed Central PMCID: PMC4236891. https://www.ncbi.nlm.nih.gov/pubmed/25538769

 

Zhang W, Islam N, Ma C, Anis AH. Systematic review of cost-effectiveness analyses of treatments for psoriasis. Pharmacoeconomics. 2015 Apr;33(4):327-40. doi: 10.1007/s40273-014-0244-9. Review. PubMed PMID: 25475964. https://www.ncbi.nlm.nih.gov/pubmed/25475964

 

Oviedo-Joekes E, Sordo L, Guh D, Marsh DC, Lock K, Brissette S, Anis AH, Schechter MT. Predictors of non-use of illicit heroin in opioid injection maintenance treatment of long-term heroin dependence. Addict Behav. 2015 Feb;41:81-6. doi: 10.1016/j.addbeh.2014.10.003. Epub 2014 Oct 7. PubMed PMID: 25452049. https://www.ncbi.nlm.nih.gov/pubmed/25452049

 

Barnett PG, Chow A, Joyce VR, Bayoumi AM, Griffin SC, Sun H, Holodniy M, Brown ST, Cameron W, Sculpher M, Youle M, Anis AH, Owens DK. Effect of management strategies and clinical status on costs of care for advanced HIV. Am J Manag Care. 2014 May;20(5):e129-37. PubMed PMID: 25326927. https://www.ncbi.nlm.nih.gov/pubmed/25326927

 

Oviedo-Joekes E, Marchand K, Lock K, Chettiar J, Marsh DC, Brissette S, Anis AH, Schechter MT. A chance to stop and breathe: participants’ experiences in the North American Opiate Medication Initiative clinical trial. Addict Sci Clin Pract. 2014 Sep 29;9:21. doi: 10.1186/1940-0640-9-21. PubMed PMID: 25262567; PubMed Central PMCID: PMC4181618. https://www.ncbi.nlm.nih.gov/pubmed/25262567

 

Linder A, Guh D, Boyd JH, Walley KR, Anis AH, Russell JA. Long-term (10-year) mortality of younger previously healthy patients with severe sepsis/septic shock is worse than that of patients with nonseptic critical illness and of the general population. Crit Care Med. 2014 Oct;42(10):2211-8. doi: 10.1097/CCM.0000000000000503. PubMed PMID: 25054672. https://www.ncbi.nlm.nih.gov/pubmed/25054672

 

Oviedo-Joekes E, Guh D, Marchand K, Marsh DC, Lock K, Brissette S, Anis AH, Schechter MT. Differential long-term outcomes for voluntary and involuntary transition from injection to oral opioid maintenance treatment. Subst Abuse Treat Prev Policy. 2014 Jun 8;9:23. doi: 10.1186/1747-597X-9-23. PubMed PMID: 24908387; PubMed Central PMCID: PMC4064505. https://www.ncbi.nlm.nih.gov/pubmed/24908387

 

Rahman MM, Cibere J, Goldsmith CH, Anis AH, Kopec JA. Osteoarthritis incidence and trends in administrative health records from British Columbia, Canada. J Rheumatol. 2014 Jun;41(6):1147-54. doi: 10.3899/jrheum.131011. Epub 2014 Apr 15. PubMed PMID: 24737915. https://www.ncbi.nlm.nih.gov/pubmed/24737915

 

Nosyk B, Fischer B, Sun H, Marsh DC, Kerr T, Rehm JT, Anis AH. High levels of opioid analgesic co-prescription among methadone maintenance treatment clients in British Columbia, Canada: results from a population-level retrospective cohort study. Am J Addict. 2014 May-Jun;23(3):257-64. doi: 10.1111/j.1521-0391.2014.12091.x. PubMed PMID: 24724883; PubMed Central PMCID: PMC4033518. https://www.ncbi.nlm.nih.gov/pubmed/24724883

 

Zhang W, Anis AH. Health-related productivity loss: NICE to recognize soon, good to discuss now. Pharmacoeconomics. 2014 May;32(5):425-7. doi: 10.1007/s40273-014-0149-7. PubMed PMID: 24639039. https://www.ncbi.nlm.nih.gov/pubmed/24639039

 

Werker GR, Sharif B, Sun H, Cooper C, Bansback N, Anis AH. Optimal timing of influenza vaccination in patients with human immunodeficiency virus: a Markov cohort model based on serial study participant hemoagglutination inhibition titers. Vaccine. 2014 Feb 3;32(6):677-84. doi: 10.1016/j.vaccine.2013.11.103. Epub 2013 Dec 16. PubMed PMID: 24355089. https://www.ncbi.nlm.nih.gov/pubmed/24355089

 

Li X, Sun H, Marsh DC, Anis AH. Factors associated with pretreatment and treatment dropouts: comparisons between Aboriginal and non-Aboriginal clients admitted to medical withdrawal management. Harm Reduct J. 2013 Dec 10;10:38. doi: 10.1186/1477-7517-10-38. PubMed PMID: 24325629; PubMed Central PMCID: PMC3878858. https://www.ncbi.nlm.nih.gov/pubmed/24325629

 

Bayoumi AM, Barnett PG, Joyce VR, Griffin SC, Sun H, Bansback NJ, Holodniy M, Sanders G, Brown ST, Kyriakides TC, Angus B, Cameron DW, Anis AH, Sculpher M, Owens DK. Cost-effectiveness of newer antiretroviral drugs in treatment-experienced patients with multidrug-resistant HIV disease. J Acquir Immune Defic Syndr. 2013 Dec 1;64(4):382-91. doi: 10.1097/QAI.0000000000000002. PubMed PMID: 24129369; PubMed Central PMCID: PMC3932156. https://www.ncbi.nlm.nih.gov/pubmed/24129369

 

Rahman MM, Kopec JA, Anis AH, Cibere J, Goldsmith CH. Risk of cardiovascular disease in patients with osteoarthritis: a prospective longitudinal study. Arthritis Care Res (Hoboken). 2013 Dec;65(12):1951-8. doi: 10.1002/acr.22092. PubMed PMID: 23925995. https://www.ncbi.nlm.nih.gov/pubmed/23925995

 

O’Dell JR, Mikuls TR, Taylor TH, Ahluwalia V, Brophy M, Warren SR, Lew RA, Cannella AC, Kunkel G, Phibbs CS, Anis AH, Leatherman S, Keystone E; CSP 551 RACAT Investigators. Therapies for active rheumatoid arthritis after methotrexate failure. N Engl J Med. 2013 Jul 25;369(4):307-18. doi: 10.1056/NEJMoa1303006. Epub 2013 Jun 11. PubMed PMID: 23755969. https://www.ncbi.nlm.nih.gov/pubmed/23755969

 

Sharif B, Nosyk B, Sun H, Marsh DC, Anis A. Changes in the characteristics and levels of comorbidity among new patients into methadone maintenance treatment program in British Columbia during its expansion period from 1998-2006. Subst Use Misuse. 2013 Jun;48(8):671-82. doi: 10.3109/10826084.2013.800119. Epub 2013 Jun 10. PubMed PMID: 23750776; PubMed Central PMCID: PMC5108241. https://www.ncbi.nlm.nih.gov/pubmed/23750776

 

Rahman MM, Kopec JA, Cibere J, Goldsmith CH, Anis AH. The relationship between osteoarthritis and cardiovascular disease in a population health survey: a cross-sectional study. BMJ Open. 2013 May 14;3(5). pii: e002624. doi: 10.1136/bmjopen-2013-002624. PubMed PMID: 23674445; PubMed Central PMCID: PMC3657665. https://www.ncbi.nlm.nih.gov/pubmed/23674445

 

Zhang W, Chiu JA, Bansback N, Anis AH. An update on the measurement of productivity losses due to rheumatoid diseases. Best Pract Res Clin Rheumatol. 2012 Oct;26(5):585-97. doi: 10.1016/j.berh.2012.08.008. Review. PubMed PMID: 23218424. https://www.ncbi.nlm.nih.gov/pubmed/23218424