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  • What We're Working On
Role of a new genetic variant on bone cells’ function
Genetic-Variant-on-bone-cells-PLS-image-e1671668751676
Scientific Study Title:
The impact of a rare variant of the Wnt1 gene in three types of bone cells.
Start Date:
  • January 2022
End Date:
  • December 2022
Research Category
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Laetitia Michou, Research Team Member, Arthritis Research Canada
Laëtitia Michou
Research Scientist, Rheumatology, MD, PhD

Why do this research?

Reason For Research

Our team has identified a new genetic variant in a family with 2 sisters having unusual fractures of the femur, or thigh bone. This is a rare condition which occurs after several years of treatment for osteoporosis, by a category of drugs called bisphosphonates.

Our findings may suggest a genetic component to this condition, as well as, the effects of using bisphosphonates.

What will be done?

Execution of Research

In this study, we will reproduce the genetic variant detected in our patients in different types of bone cells, to develop an in vitro model for the study of atypical femur fractures. We need to understand the interaction between genetic factors and exposure to a medication like bisphosphonate.

How Can People Get Involved?

Involvement

The laboratory team of Dr Michou, including a master student.

This study, which will focus on a cellular model. No human participants will be recruited.

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