Mental Health Matters for People With Arthritis
Scientific Study Title:
Mapping the epidemiology and the role of treatments in mental health complications in inflammatory arthritis (MATTERS)
Study Start Date:
January 2019
End Date:
December 2021
Why Do This Research?
The goal of this research is to study mental health in those with arthritis. Despite the complex relationship between arthritis and psychiatric conditions, it is an understudied issue. This will be the first study of its kind in Canada on mental health in people with arthritis. It will improve awareness of the how having arthritis affects mental health and how we can improve care for patients.
What Will Be Done?
We will use data from Population Data BC to study whether the burden of depression and anxiety in people with arthritis is increasing over time and the risk of depression and anxiety after diagnosis of arthritis. We will study how depression and anxiety are treated among people with arthritis and whether medications (biologics) for arthritis may reduce the risk of depression and anxiety.
Who Is Involved?
The research team includes practicing rheumatologists and clinician researchers, research scientists with expertise in epidemiology, health services and biostatistics, a PhD trainee, and a patient-research partner.
Research Team
Principal Investigators:
Mary De Vera, MSc, PhD, Senior Scientist, Pharmacoepidemiology, Associate Director of Training, Arthritis Research Canada (University of British Columbia)
Co-investigators:
Deborah Da Costa, PhD, Research Scientist, Psychology, Arthritis Research Canada (McGill University)
John Esdaile, MD, MPH, FRCPC, FCAHS, MACR, Scientific Director Emeritus, Arthritis Research Canada (University of British Columbia)
Joseph H. Puyat, School of Population and Public Health, (University of British Columbia)
Kamran Shojania, MD, FRCPC, Clinical Trialist, Rheumatology, Arthritis Research Canada (University of British Columbia)
J. Antonio Avina-Zubieta, MD, MSc, PhD, FRCPC, Senior Scientist, Rheumatology, Arthritis Research Canada (University of British Columbia)
Alyssa Howren, BS, MSc, PhD, Former Arthritis Research Canada Trainee (University of British Columbia)
Eileen Davidson, Arthritis Research Canada Arthritis Patient Advisory Board
BC Support Unit
Funding Agency:
The Arthritis Society
Publications
Howren A, Avina-Zubieta JA, Puyat JH, Esdaile JM, Da Costa D, De Vera MA. Defining depression and anxiety in individuals with inflammatory arthritis using administrative health databases: A systematic review. Arthritis Care Res (Hoboken). 2020 Feb;72(2):243-255. doi: 10.1002/acr.24048. Epub 2020 Jan 9.
Howren A, Bowie D, Choi HK, Rai SK, De Vera MA. Epidemiology of depression and anxiety in gout: A systematic review and meta-analysis. J Rheumatol. 2020 Mar 1. pii: jrheum.190974. doi: 10.3899/jrheum.190974. [Epub ahead of print].
Park JY, Howren A, Zusman EZ, Esdaile JM, De Vera MA. The incidence of depression and anxiety in patients with ankylosing spondylitis: A systematic review and meta-analysis. Accepted BMC Rheumatology. 2019 Dec 23.
Zusman EZ, Howren AM, Park JYE, Dutz J, De Vera MA. Epidemiology of depression and anxiety in patients with psoriatic arthritis: A systematic review and meta-analysis. Semin Arthritis Rheum. 2020 Feb 13. pii: S0049-0172(20)30020-2. doi: 10.1016/j.semarthrit.2020.02.001. [Epub ahead of print].
