Investigating the Mechanisms of Intramuscular Collagen Accumulation in Individuals with Knee Osteoarthritis

Investigating the Mechanisms of Intramuscular Collagen Accumulation in Individuals with Knee Osteoarthritis Start and end date: Current – February 25, 2026 Overview  Individuals with knee osteoarthritis (OA) have been shown to exhibit higher levels of intramuscular collagen compared to those without osteoarthritis. Increased intramuscular collagen has been associated with compromised muscle health, reduced strength, and […]

Central Nervous System Pain Mechanism and Excitability Changes in Symptomatic Knee Osteoarthritis

Central Nervous System Pain Mechanism and Excitability Changes in Symptomatic Knee Osteoarthritis Start and end date: Jul 2024- Jul 2029 Overview  Osteoarthritis is the degeneration of joint cartilage and the underlying bone, which may or may not cause pain and/or other symptoms. Increasing evidence suggests that symptomatic knee osteoarthritis involves changes in how the nervous […]

The SOAR (Stop OsteoARthritis) Clinical Trial

The SOAR (Stop OsteoARthritis) Clinical Trial Start and end date: January 1, 2021 – December 31, 2023 Overview  Many young Canadians who hurt their knees playing sports are at risk of developing osteoarthritis (OA) at a young age. Osteoarthritis can cause pain and disability, making it hard to work, take care of family, and enjoy […]