Hip Osteoarthritis Progression Evaluation (HOPE) Study

Scientific Study Title: 

Population-Based Longitudinal Cohort Study of Femoroacetabular Impingement of the Hip Using Magnetic Resonance Imaging Outcomes

Principal Investigator:

Jolanda Cibere, MD, PhD, Associate Professor, Rheumatology, Department of Medicine, UBC; Senior Research Scientist, Arthritis Research Canada.

Study Start Date: 

October 2018

Study End Date:

December 2026

Why do this research?

Hip osteoarthritis (OA) is one of the most common joint diseases and a main reason for hip replacement. Hip OA causes pain and stiffness in the hip. It can make it hard to do everyday tasks like taking a short walk, working or enjoying recreational activities.

A condition called femoroacetabular impingement (FAI) may lead to OA. FAI starts in adolescence and young adulthood. FAI occurs when extra bone grows along one, or both, of the bones that form the hip joint. This causes the bones to fit together imperfectly and create extra friction. The friction may worsen with certain physical activities and eventually lead to damage or OA in the hip joint. The link between FAI and developing hip OA is not fully understood. We do not know if, or how, physical activity affects the relationship between FAI and OA.

What will be done?

Seven years ago, we studied people with and without FAI, and with and without hip pain. We used magnetic resonance imaging (MRI) to examine the cartilage, bones and other tissues in the hip. Subjects also completed detailed hip health questionnaires, received hip x-rays, and had blood and urine samples taken for lab testing. We are now planning to assess the same people, seven years later, using similar procedures.

Our goals are to determine whether people with FAI, compared to those without FAI, are at greater risk of developing OA on MRI. We are also interested in evaluating whether different types of physical activity, alone or in combination with FAI, predicts who gets early hip OA.

Who is involved?

We are recruiting subjects who were originally involved in our study 7 years ago. This group consists of 182 people, ages 20-49 at baseline, both with and without FAI and with and without hip pain.

Co-investigators:

John Esdaile, MD, MPH, Professor, Rheumatology, Department of Medicine, UBC; Scientific Director, Arthritis Research Canada.

Bruce Forster, MSc, MD, FRCPC, Professor, Department of Radiology, UBC.

Jacek Kopec, MD, PhD, Professor, School  of Population and Public Health, UBC; Senior Research Scientist, Arthritis Research Canada.

Linda Li, BSc (PT), MSc, PhD, Professor, School of Rehabilitation Sciences, UBC; Senior Research Scientist, Arthritis Research Canada.

David Wilson, PhD, Professor, Department of Orthopaedics, UBC.

Hubert Wong, PhD, Associate Professor, School of Population and Public Health, UBC.

Collaborators:

Ali Guermazi, MD, PhD, Director of the Quantitative Imaging Center, Professor of Radiology, Section Chief of Musculoskeletal Imaging, Boston University School of Medicine.

Sheila Kerr, Emeritus member, Arthritis Patient Advisory Board.

Research Staff:

Julia Cibere, BA, Arthritis Research Canada.

Funding Agency: 

Canadian Institutes of Health Research