Arthritis Research Canada at

ACR Convergence 2023

November 15

Updated Analyses of Cancer Incidence and Risk Factors in a Large International SLE Cohort

This study aimed to assess cancer risk in an international cohort of 1,675 patients with systemic lupus erythematosus (SLE). Over 10 years of follow-up, 72 cases of cancer were documented, with breast, skin, and lung cancers being the most common. The analysis showed that older age, male gender, and heavy smoking were linked to higher cancer risk across all types. Antimalarials (e.g. hydroxychloroquine) appeared to decrease the risk of breast cancer, but this was not seen for other cancer types, while age at SLE diagnosis and cyclophosphamide use were associated with non-melanoma skin cancer risk.

Research Team: Bernatsky S, Ramsey-Goldman R, Urowitz M, Hanly JG, Gordon C, Petri M, Ginzler E, Wallace D, Bae SC, Romero-Diaz J, Dooley MA, Peschken C, Isenberg D, Rahman A, Manzi S, Jacobsen S, Lim SS, van Vollenhoven R, Nived O, Kamen DL, Aranow C, Buyon J, Ruiz-Irastorza G, Sanchez-Guerrero F, Gladman D, Fortin PR, Lee JLF, Lukusa L, Alarcón GS, Merrill J, Kalunian K, Ramos-Casals M, Steinsson K, Zoma A, Askanase A, Khamashta M, Bruce I, Inanç M, Clarke A.



Machine Learning Identifies New Sporadic Inclusion Body Myositis Endotypes Associated with Unique Autoantibody Profiles

This study evaluated whether people living with inflammatory arthritis newly diagnosed with depression and anxiety received adequate mental health care. The findings emphasize substantial undertreatment of depression and anxiety, with only half of people receiving medications and one in five people receiving provincially-funded mental health services.

Research Team: Wei J, Tarnopolsky M, Hudson M, Mitchell R, Buhler K, Dufour A, de Almeida L, Fortin PR, Boilard E, Becker Y, Hatcher E, Zhang MF, Fritzler M, Choi M.


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